Skip to main content

Advertisement

Log in

Clinical Diagnosis of Metastatic Gastric Tumors: Clinicopathologic Findings and Prognosis of Nine Patients in a Single Cancer Center

  • Original Scientific Reports
  • Published:
World Journal of Surgery Aims and scope Submit manuscript

Abstract

The clinical features of metastatic gastric tumors (MGTs) have not been well documented. We present a clinical series of nine patients with MGTs. Among 2579 patients with gastric tumors seen between 1992 and 2001, we studied 9 (0.3%) patients with MGT according to a prospective database. The MGTs were diagnosed based on findings in the surgical or endoscopic specimen, and patients with malignant lymphoma or direct invasion from adjacent organs were excluded from the study. MGTs were detected simultaneously with the primary tumors in three and afterward in six patients at 14 to 74 months. The primary tumors included one each of squamous cell carcinoma of the esophagus, signet-ring cell carcinoma of the breast, large-cell or small-cell carcinoma of the lung, renal cell carcinoma, hepatocellular carcinoma, squamous cell or epidermoid carcinoma of the uterus, and melanoma. Multiple organ metastases were present simultaneously in six patients. Although six patients underwent gastrectomy, macroscopic eradication of gastric metastatic disease was accomplished in only four, in whom a UICC R0 resection was possible in only two. Five patients were treated by chemotherapy with no apparent survival benefit. A median survival after MGT diagnosis was 170 days (range 16-892 days) for all cases, 384 days for those who underwent gastrectomy (n = 6), and 27 days for those without active treatment (n = 3) (p = 0.002). The cause of death was multiple organ metastases in most cases. Because multiple metastases are common, the prognosis of MGT is poor even after curative resection. MGT is likely to be a preterminal event, and surgical resection may be useful only for palliation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Ming SC. Tumors of the esophagus and stomach. In Atlas of Tumor Pathology, Washington, DC, Armed Forces Institute of Pathology, 1973;253–255

  2. PM Higgins (1962) ArticleTitlePyloric obstruction due to a metastatic deposit from carcinoma of the bronchus Can. J. Surg. 5 438–441 Occurrence Handle1:STN:280:CC2C2cnhsVc%3D Occurrence Handle13954414

    CAS  PubMed  Google Scholar 

  3. GH Davis RW Zollinger (1960) ArticleTitleMetastatic melanoma of the stomach Am. J. Surg. 99 94–96 Occurrence Handle10.1016/0002-9610(60)90258-0 Occurrence Handle1:STN:280:CC%2BC3svovFA%3D Occurrence Handle13814449

    Article  CAS  PubMed  Google Scholar 

  4. LS Menuck JR Amberg (1975) ArticleTitleMetastatic disease involving the stomach Am. J. Dig. Dis. 20 903–913 Occurrence Handle1:STN:280:CSmD2MbitVA%3D Occurrence Handle1190198

    CAS  PubMed  Google Scholar 

  5. I Oda H Kondo T Yamao et al. (2001) ArticleTitleMetastatic tumors to the stomach: analysis of 54 patients diagnosed at endoscopy and 347 autopsy cases Endoscopy 33 507–510 Occurrence Handle10.1055/s-2001-14960 Occurrence Handle1:STN:280:DC%2BD38%2FhvVGgtQ%3D%3D Occurrence Handle11437044

    Article  CAS  PubMed  Google Scholar 

  6. BG Taal H Peterse H Boot (2000) ArticleTitleClinical presentation, endoscopic features, and treatment of gastric metastases from breast carcinoma Cancer 89 2214–2221 Occurrence Handle10.1002/1097-0142(20001201)89:11<2214::AID-CNCR9>3.3.CO;2-4 Occurrence Handle1:STN:280:DC%2BD3M%2FosF2ruw%3D%3D Occurrence Handle11147591

    Article  CAS  PubMed  Google Scholar 

  7. T Saito T Iizuka H Kato et al. (1985) ArticleTitleEsophageal carcinoma metastatic to the stomach: a clinicopathologic study of 35 cases Cancer 56 2235–2241 Occurrence Handle1:STN:280:BimD38jntF0%3D Occurrence Handle4052968

    CAS  PubMed  Google Scholar 

  8. InstitutionalAuthorNameJapanese Gastric Cancer Association (1998) ArticleTitleJapanese classification of gastric carcinoma, 2nd English edition Gastric Cancer 1 25–30

    Google Scholar 

  9. RS Sandler RB Sartor EM Bozymski (1981) ArticleTitleEndoscopic appearance of cancer metastatic to the stomach J. Clin. Gastroenterol. 3 35–37

    Google Scholar 

  10. M Picchio A Paioletti E Santini et al. (2000) ArticleTitleGastric metastasis from renal cell carcinoma fourteen years after radical nephrectomy Acta Chir. Belg. 100 228–230 Occurrence Handle1:STN:280:DC%2BD3M7hsVamtw%3D%3D Occurrence Handle11143327

    CAS  PubMed  Google Scholar 

  11. RR Taylor WS Phillips DM O’Connor et al. (1994) ArticleTitleUnusual intramural gastric metastasis of recurrent epithelial ovarian carcinoma Gynecol. Oncol. 55 152–155 Occurrence Handle10.1006/gyno.1994.1266 Occurrence Handle1:STN:280:ByqD2cjnsFM%3D Occurrence Handle7959258

    Article  CAS  PubMed  Google Scholar 

  12. T Miyashita E Hoshino T Imamura et al. (1994) ArticleTitleA case of appendiceal cancer metastatic to the stomach with pseudomyxoma peritonei J. Gastroenterol. 29 71–75 Occurrence Handle1:STN:280:ByuB2MfjtFI%3D Occurrence Handle7515309

    CAS  PubMed  Google Scholar 

  13. K Okabayashi T Hanagiri Y Noda et al. (1993) ArticleTitleAngiosarcoma of the chest wall with a gastric metastasis Thorac. Cardiovasc. Surg. 41 318–320 Occurrence Handle1:STN:280:ByuC3srnt1U%3D Occurrence Handle8303703

    CAS  PubMed  Google Scholar 

  14. MH Wang MS Wu HP Wang et al. (2000) ArticleTitleEndoscopic manifestations of metastatic hepatocellular carcinoma to the stomach: report of two cases Gastrointest. Endosc. 52 273–275 Occurrence Handle10.1067/mge.2000.109800 Occurrence Handle1:STN:280:DC%2BD3cvlslymtg%3D%3D Occurrence Handle10922110

    Article  CAS  PubMed  Google Scholar 

  15. A Aydiner V Olgac E Darendeliler et al. (1993) ArticleTitleTesticular germ cell tumor with gastric metastasis Acta Oncol. 32 459–460 Occurrence Handle1:STN:280:ByyA2sfnsVM%3D Occurrence Handle8396398

    CAS  PubMed  Google Scholar 

  16. H Kimura S Kinoshita I Takahashi (2002) ArticleTitleGastric metastases from accessory breast cancer Gastrointest. Endosc. 56 566–567 Occurrence Handle10.1067/mge.2002.127150 Occurrence Handle12297779

    Article  PubMed  Google Scholar 

  17. H Konishi K Isetani T Satoh et al. (1994) ArticleTitleA case of metastatic chondrosarcoma of the stomach J. Gastroenterol. 29 495–500 Occurrence Handle1:STN:280:ByqD3sbls1Q%3D Occurrence Handle7951861

    CAS  PubMed  Google Scholar 

  18. WJ Cormier TA Gaffey JM Welch et al. (1980) ArticleTitleLinitis plastica caused by metastatic lobular carcinoma of the breast Mayo Clin Pro. 55 747–753 Occurrence Handle1:STN:280:Bi6C2s7lslY%3D

    CAS  Google Scholar 

  19. AS Antler Y Ough W Thelmo et al. (1982) ArticleTitleGastrointestinal metastases from malignant tumors of the lung Cancer 49 170–172 Occurrence Handle1:STN:280:Bi2D1Mzgs1c%3D Occurrence Handle6274500

    CAS  PubMed  Google Scholar 

  20. JK Patel MS Didolkar JW Pickren et al. (1978) ArticleTitleMetastatic pattern of malignant melanoma Am. J. Surg. 135 807–810 Occurrence Handle10.1016/0002-9610(78)90171-X Occurrence Handle1:STN:280:CSeB3cfnsVI%3D Occurrence Handle665907

    Article  CAS  PubMed  Google Scholar 

  21. MA Meyers J McSweeney (1972) ArticleTitleSecondary neoplasms of the bowel Radiology 105 1–11 Occurrence Handle1:STN:280:CS2B28bos1U%3D Occurrence Handle5066554

    CAS  PubMed  Google Scholar 

  22. SA Rubin M Davis (1985) ArticleTitle“Bull’s eye” or “target” lesions of the stomach secondary to carcinoma of the lung Am. J. Gastroenterol. 80 67–69 Occurrence Handle1:STN:280:BiqD1MvitFE%3D Occurrence Handle3966457

    CAS  PubMed  Google Scholar 

  23. MM Reeder RC Cavanagh (1974) ArticleTitle“Bull’s eye” lesions: solitary or multiple nodules in the gastrointestinal tract with large central ulceration JAMA 229 825–826 Occurrence Handle10.1001/jama.229.7.825 Occurrence Handle1:STN:280:CSuB2svitFc%3D Occurrence Handle4407823

    Article  CAS  PubMed  Google Scholar 

  24. N Joffe (1975) ArticleTitleMetastatic involvement of the stomach secondary to breast carcinoma AJR. Am. J. Roentgenol. 123 512–521 Occurrence Handle1:STN:280:CSqC2cvisVQ%3D

    CAS  Google Scholar 

  25. S Basu A Last M Shinkfield (2002) ArticleTitleInvasive lobular carcinoma of the breast presenting successively with colonic and gastric metastases Int. J. Clin. Pract. 56 623–625 Occurrence Handle1:STN:280:DC%2BD38nmsVOkug%3D%3D Occurrence Handle12425377

    CAS  PubMed  Google Scholar 

  26. G Lorimier C Binelli P Burtin et al. (1998) ArticleTitleMetastatic gastric cancer arising from breast carcinoma: endoscopic ultrasonographic aspects Endoscopy 30 800–804 Occurrence Handle1:STN:280:DyaK1M7ivFGnsA%3D%3D Occurrence Handle9932762

    CAS  PubMed  Google Scholar 

  27. T Odori Y Tsuboi K Katoh et al. (1998) ArticleTitleA solitary hematogenous metastasis to the gastric wall from renal cell carcinoma four years after radical nephrectomy J. Clin. Gastroenterol. 26 153–154 Occurrence Handle10.1097/00004836-199803000-00015 Occurrence Handle1:STN:280:DyaK1c3itlChsg%3D%3D Occurrence Handle9563931

    Article  CAS  PubMed  Google Scholar 

  28. LK Green S Zachariah DY Graham (1990) ArticleTitleDiagnosis of metastatic lesions to the stomach by salvage cytology Dig. Dis. Sci. 35 1421–1425 Occurrence Handle1:STN:280:By6D3s%2FptVQ%3D Occurrence Handle2226104

    CAS  PubMed  Google Scholar 

  29. L Zelek PH Cottu L Mignot et al. (2001) ArticleTitleGastric metastases from breast cancer Am. J. Clin. Oncol. 24 363–365 Occurrence Handle10.1097/00000421-200108000-00009 Occurrence Handle1:STN:280:DC%2BD3MvislSjtw%3D%3D Occurrence Handle11474262

    Article  CAS  PubMed  Google Scholar 

  30. JK Ihde DG Coit (1991) ArticleTitleMelanoma metastatic to stomach, small bowel, or colon Am. J. Surg. 162 208–211 Occurrence Handle10.1016/0002-9610(91)90070-T Occurrence Handle1:STN:280:By2D38nntFM%3D Occurrence Handle1718180

    Article  CAS  PubMed  Google Scholar 

  31. JC Pector F Crokaert F Lejeune et al. (1988) ArticleTitleProlonged survival after resection of malignant melanoma metastatic to the stomach Cancer 61 2134–2135 Occurrence Handle1:STN:280:BieC1MvislA%3D Occurrence Handle3359409

    CAS  PubMed  Google Scholar 

  32. N Suzaki A Hiraki H Ueoka et al. (2002) ArticleTitleGastric perforation due to metastasis from adenocarcinoma of the lung Anticancer Res. 22 1209–1212 Occurrence Handle12168927

    PubMed  Google Scholar 

  33. T Kishino Y Yamaguchi T Yamagishi et al. (2000) ArticleTitleSubmucosal tumor (SMT)-like esophageal squamous cell carcinoma with gastric metastasis Hepatogastroenterology. 47 1581–1584 Occurrence Handle1:STN:280:DC%2BD3M7itlSkug%3D%3D Occurrence Handle11149006

    CAS  PubMed  Google Scholar 

  34. G Jeladharan N Subhalal I Praseeda (1992) ArticleTitleGastric ulcer due to metastasis from carcinoma cervix Indian J. Gastroenterol. 11 88 Occurrence Handle1:STN:280:ByyD2M3lvFM%3D Occurrence Handle1428039

    CAS  PubMed  Google Scholar 

  35. CS Wu CM Chen SY Tung et al. (1996) ArticleTitleUpper gastrointestinal bleeding due to metastatic gastric and duodenal squamous-cell carcinoma from the hypopharynx Endoscopy 28 262 Occurrence Handle1:STN:280:BymA3MvgvVQ%3D Occurrence Handle8739747

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Osamu Kobayashi M.D..

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kobayashi, O., Murakami, H., Yoshida, T. et al. Clinical Diagnosis of Metastatic Gastric Tumors: Clinicopathologic Findings and Prognosis of Nine Patients in a Single Cancer Center. World J. Surg. 28, 548–551 (2004). https://doi.org/10.1007/s00268-004-7216-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00268-004-7216-8

Keywords

Navigation