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Barrett’s Esophagus: Environmental Influences in the Progression of Dysplasia

  • World Progress in Surgery
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Abstract

Barrett’s esophagus (BE) is composed of multiple lineages including Paneth cells and endocrine cells in addition to gastric and intestinal cells. Although the origin of the BE stem cell is a matter of conjecture, the stem cells are clearly multipotent, and therefore the phenotype is restricted by genomic imprinting (termed restricted potency). Recent evidence suggests that the microenvironment may select various lineages. In this regard the proportion of gastric and specialized intestinal metaplastic cells has been attributed to the composition of the refluxate, acid or bile, respectively. Experimental evidence also implicates specific xenobiotics in this process, including bile acids. In particular we discuss the potential biologic roles of bile acids in epithelial adaptation from in vivo and in vitro models.

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Authors and Affiliations

  1. University Department of Cancer Studies and Molecular Medicine, Leicester Medical School at University Hospitals Leicester Trust, Leicester Royal Infirmary, Level 4, Windsor Building, Leicester LE1 5WW, UK

    Ralph A. Boulton M.B., Ph.D., Bernhard Usselmann M.B., M.R.C.P., Imtiyaz Mohammed M.B., M.R.C.P. & Janusz Jankowski M.D., Ph.D.

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  1. Ralph A. Boulton M.B., Ph.D.
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  2. Bernhard Usselmann M.B., M.R.C.P.
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  3. Imtiyaz Mohammed M.B., M.R.C.P.
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  4. Janusz Jankowski M.D., Ph.D.
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Correspondence to Janusz Jankowski M.D., Ph.D..

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Boulton, R., Usselmann, B., Mohammed, I. et al. Barrett’s Esophagus: Environmental Influences in the Progression of Dysplasia. World J. Surg. 27, 1014–1017 (2003). https://doi.org/10.1007/s00268-003-7054-0

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