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Postoperative Scar Management Protocol for Asian Patients

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Abstract

Background

Postoperative scar formation remains a morbidity for patients even with the advent of minimally invasive techniques. Furthermore, the significant difference between the Asian and Caucasian skin results in poorer postoperative scar outcomes in Asians, supporting the need for an evidence-based scar management protocol.

Methods

Following a literature review of the PubMed and the Cochrane databases over the past 10 years, we constructed a novel postoperative scar management protocol for the Asian skin, utilized in a Singaporean tertiary healthcare institution.

Results

We describe a timeline-based scar protocol from the point of skin closure to a minimum of 1 year of follow-up. We support the use of intraoperative botulinum toxin for selected high-risk individuals upon skin closure with a follow-up regimen in the postoperative setting. For recalcitrant keloids, we have described a multimodal therapy comprising elements of intralesional steroids, botulinum toxin, lasers, surgery, and radiotherapy.

Conclusions

A consolidated postoperative scar management protocol provides the necessary guidance for improved scar outcomes in the Asian skin. There is inherent potential in expanding the protocol to include post-traumatic and burn wounds or support other skin types including the Caucasian skin.

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References

  1. Soltani AM, Francis CS, Motamed A, Karatsonyi AL, Hammoudeh JA, Sanchez-Lara PA et al (2012) Hypertrophic scarring in cleft lip repair: a comparison of incidence among ethnic groups. Clin Epidemiol 4:187–191

    PubMed  PubMed Central  Google Scholar 

  2. Ogawa R, Dohi T, Tosa M, Aoki M, Akaishi S (2021) The latest strategy for keloid and hypertrophic scar prevention and treatment: the nippon medical school (NMS) protocol. J Nippon Med Sch 88(1):2–9

    Article  CAS  PubMed  Google Scholar 

  3. Lv K, Xia Z (2018) Chinese expert consensus on clinical prevention and treatment of scar. Burns Trauma 6:27

    Article  PubMed  PubMed Central  Google Scholar 

  4. Potter DA, Veitch D, Johnston GA (2019) Scarring and wound healing. Br J Hosp Med Lond 80(11):C166–C171

    Article  PubMed  Google Scholar 

  5. Dohi T, Padmanabhan J, Akaishi S, Than PA, Terashima M, Matsumoto NN et al (2019) The interplay of mechanical stress, strain, and stiffness at the keloid periphery correlates with increased caveolin-1/ROCK signaling and scar progression. Plast Reconstr Surg 144(1):58e–67e

    Article  CAS  PubMed  Google Scholar 

  6. Quong WL, Kozai Y, Ogawa R (2017) A case of keloids complicated by castleman’s disease: interleukin-6 as a keloid risk factor. Plast Reconstr Surg Glob Open 5(5):e1336

    Article  PubMed  PubMed Central  Google Scholar 

  7. van der Veer WM, Bloemen MC, Ulrich MM, Molema G, van Zuijlen PP, Middelkoop E et al (2009) Potential cellular and molecular causes of hypertrophic scar formation. Burns 35(1):15–29

    Article  PubMed  Google Scholar 

  8. Ogawa R (2017) Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci 18(3):526489

    Article  ADS  Google Scholar 

  9. Ogawa R, Okai K, Tokumura F, Mori K, Ohmori Y, Huang C et al (2012) The relationship between skin stretching/contraction and pathologic scarring: the important role of mechanical forces in keloid generation. Wound Repair Regen 20(2):149–157

    Article  PubMed  Google Scholar 

  10. Harn HI, Ogawa R, Hsu CK, Hughes MW, Tang MJ, Chuong CM (2019) The tension biology of wound healing. Exp Dermatol 28(4):464–471

    Article  PubMed  Google Scholar 

  11. Park TH, Chang CH (2012) Keloid recurrence in pregnancy. Aesthet Plast Surg 36(5):1271–1272

    Article  Google Scholar 

  12. Kim HD, Hwang SM, Lim KR, Jung YH, Ahn SM, Kim SJ (2013) Recurrent auricular keloids during pregnancy. Arch Plast Surg 40(1):70–72

    Article  PubMed  PubMed Central  Google Scholar 

  13. Arima J, Huang C, Rosner B, Akaishi S, Ogawa R (2015) Hypertension: a systemic key to understanding local keloid severity. Wound Repair Regen. 23(2):213–221

    Article  PubMed  Google Scholar 

  14. Dong X, Mao S, Wen H (2013) Upregulation of proinflammatory genes in skin lesions may be the cause of keloid formation (Review). Biomed Rep 1(6):833–836

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Marneros AG, Norris JE, Olsen BR, Reichenberger E (2001) Clinical genetics of familial keloids. Arch Dermatol 137(11):1429–1434

    Article  CAS  PubMed  Google Scholar 

  16. Nakashima M, Chung S, Takahashi A, Kamatani N, Kawaguchi T, Tsunoda T et al (2010) A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population. Nat Genet 42(9):768–771

    Article  CAS  PubMed  Google Scholar 

  17. Ogawa R, Watanabe A, Than Naing B, Sasaki M, Fujita A, Akaishi S et al (2014) Associations between keloid severity and single-nucleotide polymorphisms: importance of rs8032158 as a biomarker of keloid severity. J Invest Dermatol 134(7):2041–2043

    Article  CAS  PubMed  Google Scholar 

  18. Fujita M, Yamamoto Y, Jiang JJ, Atsumi T, Tanaka Y, Ohki T et al (2019) NEDD4 Is involved in inflammation development during keloid formation. J Invest Dermatol 139(2):333–341

    Article  CAS  PubMed  Google Scholar 

  19. Abdu Allah AMK, Mohammed KI, Farag AGA, Hagag MM, Essam M, Tayel NR (2019) Interleukin-6 serum level and gene polymorphism in keloid patients. Cell Mol Biol Noisy Grand 65(5):43–48

    Article  Google Scholar 

  20. Chen Y, Gao JH, Liu XJ, Yan X, Song M (2006) Characteristics of occurrence for Han Chinese familial keloids. Burns 32(8):1052–1059

    Article  PubMed  Google Scholar 

  21. Hosalkar H, Greenberg J, Gaugler RL, Garg S, Dormans JP (2007) Abnormal scarring with keloid formation after osteochondroma excision in children with multiple hereditary exostoses. J Pediatr Orthop 27(3):333–337

    Article  PubMed  Google Scholar 

  22. Miller MC, Nanchahal J (2005) Advances in the modulation of cutaneous wound healing and scarring. Bio Drugs 19(6):363–381

    CAS  Google Scholar 

  23. Ogawa R, Miyashita T, Hyakusoku H, Akaishi S, Kuribayashi S, Tateno A (2007) Postoperative radiation protocol for keloids and hypertrophic scars: statistical analysis of 370 sites followed for over 18 months. Ann Plast Surg 59(6):688–691

    Article  CAS  PubMed  Google Scholar 

  24. Reiffel RS (1995) Prevention of hypertrophic scars by long-term paper tape application. Plast Reconstr Surg 96(7):1715–1718

    Article  CAS  PubMed  Google Scholar 

  25. Son D, Harijan A (2014) Overview of surgical scar prevention and management. J Korean Med Sci 29(6):751–757

    Article  PubMed  PubMed Central  Google Scholar 

  26. Lubczynska A, Garncarczyk A, Wcislo-Dziadecka D (2023) Effectiveness of various methods of manual scar therapy. Skin Res Technol 29(3):e13272

    Article  PubMed  PubMed Central  Google Scholar 

  27. Singapore Government (2022) Health sciences authority Singapore [cited 2022 24th August 2022]. Available from: https://www.hsa.gov.sg/

  28. Monstrey S, Middelkoop E, Vranckx JJ, Bassetto F, Ziegler UE, Meaume S et al (2014) Updated scar management practical guidelines: non-invasive and invasive measures. J Plast Reconstr Aesthet Surg 67(8):1017–1025

    Article  PubMed  Google Scholar 

  29. Kim S, Choi TH, Liu W, Ogawa R, Suh JS, Mustoe TA (2013) Update on scar management: guidelines for treating Asian patients. Plast Reconstr Surg 132(6):1580–1589

    Article  CAS  PubMed  Google Scholar 

  30. O’Brien L, Jones DJ (2013) Silicone gel sheeting for preventing and treating hypertrophic and keloid scars. Cochr Database Syst Rev 2013(9):003826

    Google Scholar 

  31. Hsu KC, Luan CW, Tsai YW (2017) Review of silicone gel sheeting and silicone gel for the prevention of hypertrophic scars and keloids. Wounds 29(5):154–158

    PubMed  Google Scholar 

  32. Chan KY, Lau CL, Adeeb SM, Somasundaram S, Nasir-Zahari M (2005) A randomized, placebo-controlled, double-blind, prospective clinical trial of silicone gel in prevention of hypertrophic scar development in median sternotomy wound. Plast Reconstr Surg 116(4):1013–20

    Article  CAS  PubMed  Google Scholar 

  33. Sharma M, Wakure A (2013) Scar revision. Indian J Plast Surg. 46(2):408–418

    Article  PubMed  PubMed Central  Google Scholar 

  34. Jourdan M, Madfes DC, Lima E, Tian Y, Seite S (2019) Skin care management for medical and aesthetic procedures to prevent scarring. Clin Cosmet Investig Dermatol 12:799–804

    Article  PubMed  PubMed Central  Google Scholar 

  35. Commander SJ, Chamata E, Cox J, Dickey RM, Lee EI (2016) Update on postsurgical scar management. Semin Plast Surg 30(3):122–128

    Article  PubMed  PubMed Central  Google Scholar 

  36. Cho JW, Cho SY, Lee SR, Lee KS (2010) Onion extract and quercetin induce matrix metalloproteinase-1 in vitro and in vivo. Int J Mol Med 25(3):347–352

    MathSciNet  CAS  PubMed  Google Scholar 

  37. Jenwitheesuk K, Surakunprapha P, Jenwitheesuk K, Kuptarnond C, Prathanee S, Intanoo W (2012) Role of silicone derivative plus onion extract gel in presternal hypertrophic scar protection: a prospective randomized, double blinded, controlled trial. Int Wound J 9(4):397–402

    Article  PubMed  Google Scholar 

  38. Khansa I, Harrison B, Janis JE (2016) Evidence-based scar management: how to improve results with technique and technology. Plast Reconstr Surg 138(3 Suppl):165S-S178

    Article  CAS  PubMed  Google Scholar 

  39. Hosnuter M, Payasli C, Isikdemir A, Tekerekoglu B (2007) The effects of onion extract on hypertrophic and keloid scars. J Wound Care 16(6):251–254

    Article  CAS  PubMed  Google Scholar 

  40. Chung VQ, Kelley L, Marra D, Jiang SB (2006) Onion extract gel versus petrolatum emollient on new surgical scars: prospective double-blinded study. Dermatol Surg 32(2):193–197

    CAS  PubMed  Google Scholar 

  41. Gold MH, Berman B, Clementoni MT, Gauglitz GG, Nahai F, Murcia C (2014) Updated international clinical recommendations on scar management: part 1–evaluating the evidence. Dermatol Surg 40(8):817–824

    CAS  PubMed  Google Scholar 

  42. Shin TM, Bordeaux JS (2012) The role of massage in scar management: a literature review. Dermatol Surg 38(3):414–423

    Article  CAS  PubMed  Google Scholar 

  43. Aarabi S, Bhatt KA, Shi Y, Paterno J, Chang EI, Loh SA et al (2007) Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. Faseb J 21(12):3250–3261

    Article  CAS  PubMed  Google Scholar 

  44. Berman B, Viera MH, Amini S, Huo R, Jones IS (2008) Prevention and management of hypertrophic scars and keloids after burns in children. J Craniofac Surg 19(4):989–1006

    Article  PubMed  Google Scholar 

  45. Ai JW, Liu JT, Pei SD, Liu Y, Li DS, Lin HM et al (2017) The effectiveness of pressure therapy (15–25 mmHg) for hypertrophic burn scars: a systematic review and meta-analysis. Sci Rep 7:40185

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  46. Macintyre L, Baird M (2006) Pressure garments for use in the treatment of hypertrophic scars—a review of the problems associated with their use. Burns 32(1):10–15

    Article  PubMed  Google Scholar 

  47. Ketchum LD, Smith J, Robinson DW, Masters FW (1966) The treatment of hypertrophic scar, keloid and scar contracture by triamcinolone acetonide. Plast Reconstr Surg 38(3):209–218

    Article  CAS  PubMed  Google Scholar 

  48. Morelli Coppola M, Salzillo R, Segreto F, Persichetti P (2018) Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives. Clin Cosmet Investig Dermatol 11:387–396

    Article  PubMed  PubMed Central  Google Scholar 

  49. Roques C, Teot L (2008) The use of corticosteroids to treat keloids: a review. Int J Low Extrem Wounds 7(3):137–145

    Article  PubMed  Google Scholar 

  50. Tan CWX, Tan WD, Srivastava R, Yow AP, Wong DWK, Tey HL (2019) Dissolving triamcinolone-embedded microneedles for the treatment of keloids: a single-blinded intra-individual controlled clinical trial. Dermatol Ther Heidelb 9(3):601–611

    Article  PubMed  PubMed Central  Google Scholar 

  51. Kasyanju Carrero LM, Ma WW, Liu HF, Yin XF, Zhou BR (2019) Botulinum toxin type A for the treatment and prevention of hypertrophic scars and keloids: Updated review. J Cosmet Dermatol 18(1):10–15

    Article  PubMed  Google Scholar 

  52. Li YH, Yang J, Liu JQ, Xie ST, Zhang YJ, Zhang W et al (2018) A randomized, placebo-controlled, double-blind, prospective clinical trial of botulinum toxin type A in prevention of hypertrophic scar development in median sternotomy wound. Aesthetic Plast Surg 42(5):1364–1369

    Article  PubMed  Google Scholar 

  53. Huang RL, Ho CK, Tremp M, Xie Y, Li Q, Zan T (2019) Early postoperative application of botulinum toxin type A prevents hypertrophic scarring after epicanthoplasty: a split-face, double-blind. Randomized Trial Plast Reconstr Surg 144(4):835–844

    Article  CAS  PubMed  Google Scholar 

  54. Bi M, Sun P, Li D, Dong Z, Chen Z (2019) Intralesional injection of botulinum toxin type A compared with intralesional injection of corticosteroid for the treatment of hypertrophic scar and keloid: a systematic review and meta-analysis. Med Sci Monit 25:2950–2958

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Wu WTL (2011) Skin resurfacing with Microbotox and the treatment of keloids. In: Benedetto AV (ed) Botulinum toxins in clinical aesthetic practice, 2nd edn. Informa Health Care, pp 190–205

  56. Khoury JG, Saluja R, Goldman MP (2008) The effect of botulinum toxin type A on full-face intense pulsed light treatment: a randomized, double-blind, split-face study. Dermatol Surg 34(8):1062–1069

    CAS  PubMed  Google Scholar 

  57. Gamil HD, Khattab FM, El Fawal MM, Eldeeb SE (2020) Comparison of intralesional triamcinolone acetonide, botulinum toxin type A, and their combination for the treatment of keloid lesions. J Dermatol Treat 31(5):535–544

    Article  CAS  Google Scholar 

  58. Bouzari N, Davis SC, Nouri K (2007) Laser treatment of keloids and hypertrophic scars. Int J Dermatol 46(1):80–88

    Article  CAS  PubMed  Google Scholar 

  59. Al-Mohamady Ael S, Ibrahim SM, Muhammad MM (2016) Pulsed dye laser versus long-pulsed Nd:YAG laser in the treatment of hypertrophic scars and keloid: a comparative randomized split-scar trial. J Cosmet Laser Ther 18(4):208–212

    Article  Google Scholar 

  60. Kono T, Ercocen AR, Nakazawa H, Honda T, Hayashi N, Nozaki M (2003) The flashlamp-pumped pulsed dye laser (585 nm) treatment of hypertrophic scars in Asians. Ann Plast Surg 51(4):366–371

    Article  PubMed  Google Scholar 

  61. Jin R, Huang X, Li H, Yuan Y, Li B, Cheng C et al (2013) Laser therapy for prevention and treatment of pathologic excessive scars. Plast Reconstr Surg 132(6):1747–1758

    Article  CAS  PubMed  Google Scholar 

  62. Koike S, Akaishi S, Nagashima Y, Dohi T, Hyakusoku H, Ogawa R (2014) Nd:YAG laser treatment for keloids and hypertrophic scars: an analysis of 102 cases. Plast Reconstr Surg Glob Open 2(12):e272

    Article  PubMed  Google Scholar 

  63. Tsai CH, Kao HK, Akaishi S, An-Jou Lin J, Ogawa R (2020) Combination of 1,064-nm neodymium-doped yttrium aluminum garnet laser and steroid tape decreases the total treatment time of hypertrophic scars: an analysis of 40 cases of cesarean-section scars. Dermatol Surg 46(8):1062–1067

    Article  CAS  PubMed  Google Scholar 

  64. Khatri KA, Mahoney DL, McCartney MJ (2011) Laser scar revision: a review. J Cosmet Laser Ther 13(2):54–62

    Article  PubMed  Google Scholar 

  65. Seegenschmiedt MH, Micke O, Niewald M, Mucke R, Eich HT, Kriz J et al (2015) Degro guidelines for the radiotherapy of non-malignant disorders: part III: hyperproliferative disorders. Strahlenther Onkol 191(7):541–548

    Article  PubMed  Google Scholar 

  66. Ogawa R, Tosa M, Dohi T, Akaishi S, Kuribayashi S (2019) Surgical excision and postoperative radiotherapy for keloids. Scars Burn Heal. 5:2059513119891113

    PubMed  PubMed Central  Google Scholar 

  67. Ogawa R (2022) The most current algorithms for the treatment and prevention of hypertrophic scars and keloids: a 2020 update of the algorithms published 10 years ago. Plast Reconstr Surg 149(1):79e–94e

    Article  CAS  PubMed  Google Scholar 

  68. Arima J, Dohi T, Kuribayashi S, Akaishi S, Ogawa R (2019) Z-plasty and postoperative radiotherapy for anterior chest wall keloids: an analysis of 141 patients. Plast Reconstr Surg Glob Open 7(3):e2177

    Article  PubMed  PubMed Central  Google Scholar 

  69. Dohi T, Kuribayashi S, Tosa M, Aoki M, Akaishi S, Ogawa R (2019) Z-plasty and postoperative radiotherapy for upper-arm keloids: an analysis of 38 patients. Plast Reconstr Surg Glob Open 7(11):e2496

    Article  PubMed  PubMed Central  Google Scholar 

  70. Al Aradi IK, Alawadhi SA, Alkhawaja FA, Alaradi I (2013) Earlobe keloids: a pilot study of the efficacy of keloidectomy with core fillet flap and adjuvant intralesional corticosteroids. Dermatol Surg 39(10):1514–1519

    Article  CAS  PubMed  Google Scholar 

  71. Akita S, Akino K, Yakabe A, Imaizumi T, Tanaka K, Anraku K et al (2007) Combined surgical excision and radiation therapy for keloid treatment. J Craniofac Surg 18(5):1164–1169

    Article  PubMed  Google Scholar 

  72. Singapore Department of Statistics (2020) Census of population 2020 statistical release 1. Available from: https://www.singstat.gov.sg/-/media/files/publications/cop2020/sr1/findings.pdf

  73. Alhady SM, Sivanantharajah K (1969) Keloids in various races. A review of 175 cases. Plast Reconstr Surg 44(6):564–6

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

The authors declare that they have no conflict of interest. All adapted materials from previous publications have also been adequately highlighted, with the use of in-text citations adopted where necessary.

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Authors Hargaven S Gill and Gurveer KS Gill assisted with the drafting and formulating of the manuscript. Authors Low O-Wern, Priya Tiwari and Vigneswaran Nallathamby assisted with editing of the manuscript.

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Correspondence to Priya Tiwari.

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Gill, H.S., O-Wern, L., Tiwari, P. et al. Postoperative Scar Management Protocol for Asian Patients. Aesth Plast Surg 48, 461–471 (2024). https://doi.org/10.1007/s00266-023-03696-2

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