Abstract
Purpose
The study aimed to evaluate and compare the efficacy and safety of treating atrophied labia majora with hyaluronic acid (HA) and calcium hydroxyapatite (CaHA).
Methods
Ten participants complaining of sagging or loss of volume in the labia majora were evaluated and randomly assigned to two groups—treated with CaHA or AH. Photographic documentation was taken and appreciated by the participants and by blind observers.
Results
The study showed an improvement in labia majora regarding volumization and flaccidity that was more significant after 90 days of treatment in both treatments. Besides flaccidity, volume replacement resulted in better balance and proportion between the labia majora and labia minora. The evaluators, independent and blind, judged that in 80% of the cases of the HA group and in 50% of cases of the CaHA group, there was an excellent improvement.
Conclusion
CaHA and HA are both effective and safe for treating the intimate region, and this study cannot prove the superiority of one over the other. An appropriate assessment involving the analysis of sagging and/or volume loss and the creation of a sequential treatment protocol, involving CaHA and HA, seems to be the best solution.
Level of Evidence I
Evidence obtained from at least one properly designed randomized controlled trial. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
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CLV, GELF, and RFB performed and designed the research, data analysis and wrote the article.
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The authors declare that they have no conflicts of interest to disclose for this paper. Clarissa Vilela is speaker for Toskani. Gladstone Faria is a speaker for Merz. Ricardo Boggio is speaker for Allergan.
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The study was duly submitted to the Research Ethics Committee under number 62496222.0.0000.5483 and favorable opinion to conduct the study under number 5.620.349.
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Vilela, C.L., de Lima Faria, G.E. & Boggio, R.F. Treatment of Atrophy of the Labia Majora: Calcium Hydroxyapatite or Hyaluronic Acid?. Aesth Plast Surg 48, 472–477 (2024). https://doi.org/10.1007/s00266-023-03617-3
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DOI: https://doi.org/10.1007/s00266-023-03617-3