Abstract
Background
Following COVID-19 mass vaccination campaign, new- and unknown-related reactions have emerged.
Case Report
Four months after transcutaneous lower blepharoplasty and few days after the second dose of SARS-CoV-2 Pfizer mRNA vaccination, a 57-year-old man developed a bilateral palpebral ecchymosis. While the lesion healed spontaneously on the left side, the ecchymosis on the right lower lid did not regress. It presented swelling and hard consistency, clinically involving only skin layer. No alterations were revealed upon blood tests and instrumental evaluations. Histological examination showed lymphovascular hyperplasia on a probable reactive basis. The lesion was resistant to medical and surgical therapies. After 15 months, it regressed spontaneously.
Conclusions
In the reported case, an evident chronological relationship exists between surgical site and vaccine reaction, while other etiopathogenetic factors were excluded. This case represents a previously undescribed condition linking postvaccination reaction and long-term surgical outcome.
Level of Evidence V
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Similar content being viewed by others
References
Temiz SA, Abdelmaksoud A, Wollina U, Kutlu O, Dursun R, Patil A, Lotti T, Goldust M, Vestita M (2022) Cutaneous and allergic reactions due to COVID-19 vaccinations: a review. J Cosmet Dermatol 21:4–12
Istituto Superiore di Sanità, EpiCentro - Epidemiology for Public Health (2021) National COVID-19 vaccination plan. https://www.epicentro.iss.it/en/vaccines/covid-19-vaccination-plan.
European Medicines Agency (2020) Comirnaty. https://www.ema.europa.eu/en/medicines/human/EPAR/comirnaty.
Lelli GJ, Lisman RD (2010) Blepharoplasty complications. Plast Reconstr Surg 125:1007–1017
Whipple KM, Lim LH, Korn BS, Kikkawa DO (2013) Blepharoplasty complications: prevention and management. Clin Plast Surg 40:213–224
Perozzo FAG, Punzi L, Costa AL, Bassetto F (2022) Acute calcium pyrophosphate crystal arthritis of the wrist elicited by anti-COVID-19 vaccination after carpal tunnel release. Am J Case Rep 23:e934833
Bachour Y, Bekkenk MW, Rustemeyer T, Kadouch JA (2022) Late inflammatory reactions in patients with soft tissue fillers after SARS-CoV-2 infection and vaccination: a systematic review of the literature. J Cosmet Dermatol 21:1361–1368
Bachour Y, Kadouch JA, Niessen FB (2021) The Aetiopathogenesis of Late Inflammatory Reactions (LIRs) After Soft Tissue Filler Use: A Systematic Review of the Literature. Aesthetic Plast Surg 45:1748–1759
Weitgasser L, Mahrhofer M, Schoeller T (2021) Potential immune response to breast implants after immunization with COVID-19 vaccines. Breast 59:76–78
Restifo RJ (2021) A Case Report of Capsular Contracture Immediately Following COVID-19 Vaccination. Aesthet Surg J Open Forum 3:ojab021
Mak C, Graham S, Deva A (2022) Development of acute seroma around breast implants following administration of COVID-19 vaccination. Aesthet Surg J 42:NP440–NP442
Garusi C, De Antoni E, Fiori S, Vanazzi A, Pileri SA (2023) A rare case of BIA-ALCL mass associated with mastectomy skin flap erythema after immunization with COVID-19. Aesthetic Plast Surg 47:116–121
Gambichler T, Boms S, Susok L, Dickel H, Finis C, Abu Rached N et al (2022) Cutaneous findings following COVID-19 vaccination: review of world literature and own experience. J Eur Acad Dermatol Venereol 36(2):172–180
McMahon DE, Amerson E, Rosenbach M, Lipoff JB, Moustafa D, Tyagi A, Desai SR, French LE, Lim HW, Thiers BH, Hruza GJ, Blumenthal KG, Fox LP, Freeman EE (2021) Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: a registry-based study of 414 cases. J Am Acad Dermatol 85:46–55
Kroumpouzos G, Paroikaki ME, Yumeen S, Bhargava S, Mylonakis E (2022) Cutaneous complications of mRNA and AZD1222 COVID-19 vaccines: a worldwide review. Microorganisms 10:624
Annabi E, Dupin N, Sohier P, Garel B, Franck N, Aractingi S, Guégan S, Oulès B (2021) Rare cutaneous adverse effects of COVID-19 vaccines: a case series and review of the literature. J Eur Acad Dermatol Venereol 35:e847–e850
Haseeb AA, Solyman O, Abushanab MM, Abo Obaia AS, Elhusseiny AM (2022) Ocular complications following vaccination for COVID-19: a one-year retrospective. Vaccines (Basel) 10:342
Mazzatenta C, Piccolo V, Pace G, Romano I, Argenziano G, Bassi A (2021) Purpuric lesions on the eyelids developed after BNT162b2 mRNA COVID-19 vaccine: another piece of SARS-CoV-2 skin puzzle? J Eur Acad Dermatol Venereol 35:e543–e545
Vilas Boas P, Cerroni L, Requena L (2021) Intravascular cutaneous disorders A Clinicopathologic Review. Am J Dermatopathol 43:119–136
Rongioletti F, Rebora A (2003) Cutaneous reactive angiomatoses: patterns and classification of reactive vascular proliferation. J Am Acad Dermatol 49:887–896
Ferreli C, Atzori L, Caputo V, Rongioletti F (2021) Diffuse dermal angiomatosis of the breast: an emerging entity in the setting of cutaneous reactive angiomatoses. Clin Dermatol 39:271–277
Sturm EC, Marasco IS, Katz SC (2021) Multidisciplinary management of angiosarcoma – a review. J Surg Res 257:213–220
Boukovalas S, Dillard R, Qiu S, Cole EL (2017) Intravascular papillary endothelial hyperplasia (Masson’s Tumor): diagnosis the plastic surgeon should be aware of. Plast Reconstr Surg Glob Open 5:e1122
Akdur NC, Donmez M, Gozel S, Ustun H, Hucumenoglu S (2013) Intravascular papillary endothelial hyperplasia: histomorphological and immunohistochemical features. Diagn Pathol 8:167
Pins MR, Rosenthal DI, Springfield DS, Rosenberg AE (1993) Florid extravascular papillary endothelial hyperplasia (Masson’s pseudoangiosarcoma) presenting as a soft-tissue sarcoma. Arch Pathol Lab Med 117:259–263
Funding
None.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest nor funding to disclose.
Human and Animal Participants
This article does not include studies with human participants or animals conducted by either author.
Informed Consent
The patient signed written informed consent regarding publishing his data and photographs.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Berrino, V., Berrino, P. Lower Eyelid Complication After Blepharoplasty and COVID-19 Vaccination. Aesth Plast Surg 47, 2573–2578 (2023). https://doi.org/10.1007/s00266-023-03532-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00266-023-03532-7