Skip to main content

Advertisement

SpringerLink
Log in

Assessment of the Efficacy of Cryolipolysis on Abdominal Fat Deposits: A Prospective Study

  • Original Article
  • Non-Surgical Aesthetic
  • Published:
Aesthetic Plastic Surgery Aims and scope Submit manuscript

Abstract

Background

Cryolipolysis is a non-invasive and efficacious procedure for body contouring. The effectiveness of cryolipolysis has been demonstrated on multiple areas of the body, but on a limited number of subjects. The aim of this study is to demonstrate the effectiveness and the safety of cryolipolysis in the lower abdomen adipose tissue thickness reduction.

Methods

A prospective study on 60 healthy women was carried out using CryoSlim Hybrid device. Each patient underwent two cryolipolysis sessions centered on the abdominal area. The primary endpoint was to decrease the thickness of the abdominal fat deposits. The change in the abdominal circumference and the thickness of the subcutaneous fat layer were assessed. Patient satisfaction and tolerance of the procedure were also taken into account.

Results

A significant reduction of the abdominal circumference and subcutaneous fat layer thickness was observed. The mean decrease in abdominal circumference was 2.10 cm (3.1%) 3 months after the procedure and 4.03 cm (5.8%) 6 months after the procedure. The mean decrease in fat layer thickness was 1.25 cm (43.81%) 3 months after the procedure and 1.61 cm (41.73%) 6 months after the procedure. No major adverse events were noted. All patients were very satisfied, and minimal pain was reported.

Conclusions

Cryolipolysis is an effective technique to treat abdominal localized fat deposits. No major adverse events have been described for this procedure. Our promising results should encourage further studies aimed at optimizing the efficacy of the procedure without a considerable increase in the risks.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors http://www.springer.com/00266.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.

Similar content being viewed by others

References

  1. Avram MM, Harry RS (2009) Cryolipolysis for subcutaneous fat layer reduction. Lasers Surg Med 41:703–708

    Article  PubMed  Google Scholar 

  2. McLaughlin T, Lamendola C, Liu A, Abbasi F (2011) Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity. J Clin Endocrinol Metab 96:E1756-1760

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Abraham TM, Pedley A, Massaro JM, Hoffmann U, Fox CS (2015) Association between visceral and subcutaneous adipose depots and incident cardiovascular disease risk factors. Circulation 132:1639–1647

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Rosenquist KJ, Pedley A, Massaro JM et al (2013) Visceral and subcutaneous fat quality and cardiometabolic risk. JACC Cardiovasc Imaging 6:762–771

    Article  PubMed  PubMed Central  Google Scholar 

  5. Bellini E, Grieco MP, Raposio E (2017) A journey through liposuction and liposculture: review. Ann Med Surg (Lond) 24:53–60

    Article  PubMed  Google Scholar 

  6. Mohammed BS, Cohen S, Reeds D, Young VL, Klein S (2008) Long-term effects of large-volume liposuction on metabolic risk factors for coronary heart disease. Obesity (Silver Spring) 16:2648–2651

    Article  CAS  PubMed  Google Scholar 

  7. Berry MG, Davies D (2011) Liposuction: a review of principles and techniques. J Plast Reconstr Aesthet Surg 64:985–992

    Article  CAS  PubMed  Google Scholar 

  8. Karow AM Jr, Webb WR (1965) Tissue freezing. A theory for injury and survival. Cryobiology 2:99–108

    Article  PubMed  Google Scholar 

  9. Beacham BE, Cooper PH, Buchanan CS, Weary PE (1980) Equestrian cold panniculitis in women. Arch Dermatol 116:1025–1027

    Article  CAS  PubMed  Google Scholar 

  10. Epstein EH Jr, Oren ME (1970) Popsicle panniculitis. N Engl J Med 282:966–967

    Article  PubMed  Google Scholar 

  11. Manstein D, Laubach H, Watanabe K, Farinelli W, Zurakowski D, Anderson RR (2008) Selective cryolysis: a novel method of non-invasive fat removal. Lasers Surg Med 40:595–604

    Article  PubMed  Google Scholar 

  12. Coleman SR, Sachdeva K, Egbert BM, Preciado J, Allison J (2009) Clinical efficacy of noninvasive cryolipolysis and its effects on peripheral nerves. Aesthetic Plast Surg 33:482–488

    Article  PubMed  Google Scholar 

  13. Kim J, Kim DH, Ryu HJ (2014) Clinical effectiveness of non-invasive selective cryolipolysis. J Cosmet Laser Ther 16:209–213

    Article  PubMed  Google Scholar 

  14. Ingargiola MJ, Motakef S, Chung MT, Vasconez HC, Sasaki GH (2015) Cryolipolysis for fat reduction and body contouring: safety and efficacy of current treatment paradigms. Plast Reconstr Surg 135:1581–1590

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Garibyan L, Moradi Tuchayi S, Javorsky E et al (2020) Subcutaneous fat reduction with injected ice slurry. Plast Reconstr Surg 145:725e–733e

    Article  CAS  PubMed  Google Scholar 

  16. Juhasz M, Leproux A, Durkin A, Tromberg B, Mesinkovska NA (2020) Use of a novel, noninvasive imaging system to characterize metabolic changes in subcutaneous adipose tissue after cryolipolysis. Dermatol Surg 46:1461–1464

    Article  CAS  PubMed  Google Scholar 

  17. Adjadj L, SidAhmed-Mezi M, Mondoloni M, Meningaud JP, Hersant B (2017) Assessment of the efficacy of cryolipolysis on saddlebags: a prospective study of 53 patients. Plast Reconstr Surg 140:50–57

    Article  CAS  PubMed  Google Scholar 

  18. Langin D (2010) Recruitment of brown fat and conversion of white into brown adipocytes: strategies to fight the metabolic complications of obesity? Biochim Biophys Acta 1801(3):372–376

    Article  CAS  PubMed  Google Scholar 

  19. Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB (2016) Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol (Lausanne). 13(7):30

    Google Scholar 

  20. Lipner SR (2018) Cryolipolysis for the treatment of submental fat: Review of the literature. J Cosmet Dermatol 17:145–151

    Article  PubMed  Google Scholar 

  21. Hwang IC, Kim KK, Lee KR (2020) Cryolipolysis-induced abdominal fat change: split-body trials. PLoS ONE 15:e0242782

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Falster M, Schardong J, Santos DPD et al (2020) Effects of cryolipolysis on lower abdomen fat thickness of healthy women and patient satisfaction: a randomized controlled trial. Braz J Phys Ther 24:441–448

    Article  PubMed  Google Scholar 

  23. Bernstein EF, Bloom JD, Basilavecchio LD, Plugis JM (2014) Non-invasive fat reduction of the flanks using a new cryolipolysis applicator and overlapping, two-cycle treatments. Lasers Surg Med 46:731–735

    Article  PubMed  PubMed Central  Google Scholar 

  24. Hamilton HK, Dover JS, Arndt KA (2014) Successful treatment of disfiguring hemosiderin-containing hyperpigmentation with the Q-switched 650-nm wavelength laser. JAMA Dermatol 150:1221–1222

    Article  PubMed  Google Scholar 

  25. Meyer PF, Davi Costa ESJ, Santos de Vasconcellos L, de Morais Carreiro E, Valentim da Silva RM (2018) Cryolipolysis: patient selection and special considerations. Clin Cosmet Investig Dermatol 11:499–503

    Article  PubMed  PubMed Central  Google Scholar 

  26. Meningaud JP, SidAhmed-Mezi M, Billon R, Rem K, La Padula S, Hersant B (2019) Clinical benefit of using a multifractional Er:YAG laser combined with a spatially modulated ablative (SMA) module for the treatment of striae distensae: a prospective pilot study in 20 patients. Lasers Surg Med 51(3):230–238

    Article  PubMed  Google Scholar 

  27. Hersant B, La Padula S, SidAhmed-Mezi M, Rodriguez AM, Meningaud JP (2017) Use of platelet-rich plasma (PRP) in microsurgery. J Stomatol, Oral Maxillofac Surg 118(4):236–237

    Article  CAS  PubMed  Google Scholar 

  28. La Padula S, Hersant B, Bompy L, Meningaud JP (2019) In search of a universal and objective method to assess facial aging: The new face objective photo-numerical assessment scale. J Craniomaxillofac Surg 47(8):1209–1215

    Article  PubMed  Google Scholar 

  29. Ruiz R, Hersant B, La Padula S, Meningaud JP (2018) Facelifts: Improving the long-term outcomes of lower face and neck rejuvenation surgery: The lower face and neck rejuvenation combined method. J Craniomaxillofac Surg 46(4):697–704

    Article  PubMed  Google Scholar 

  30. La Padula S, Hersant B, Meningaud JP (2018) Intraoperative use of indocyanine green angiography for selecting the more reliable perforator of the anterolateral thigh flap: a comparison study. Microsurgery 38(7):738–744. https://doi.org/10.1002/micr.30326

    Article  PubMed  Google Scholar 

  31. La Padula S, Hersant B, Pizza C, Chesné C, Jamin A, Ben Mosbah I, Errico C, DAndrea F, Rega U, Persichetti P, Meningaud JP (2021) Striae distensae: in vitro study and assessment of combined treatment with sodium ascorbate and platelet-rich plasma on fibroblasts. Aesthet Plast Surg 45(3):1282–1293

    Article  Google Scholar 

  32. La Padula S, Hersant B, Chatel H, Aguilar P, Bosc R, Roccaro G, Ruiz R, Meningaud JP (2019) One-step facial feminization surgery: the importance of a custom-made preoperative planning and patient satisfaction assessment. J Plast Reconstr Aesthet Surg 72(10):1694–1699

    Article  PubMed  Google Scholar 

  33. Hersant B, SidAhmed-Mezi M, La Padula S, Niddam J, Bouhassira J, Meningaud JP (2016) Efficacy of autologous platelet-rich plasma glue in weight loss sequelae surgery and breast reduction: a prospective study. Plast Reconstr Surg Glob Open 4(11):e871

    Article  PubMed  PubMed Central  Google Scholar 

  34. Hersant B, SidAhmed-Mezi M, Aboud C, Niddam J, Levy S, Mernier T, LaPadula S, Meningaud JP (2021) Synergistic effects of autologous platelet-rich plasma and hyaluronic acid injections on facial skin rejuvenation. Aesthet Surg J 41(7):NP854–NP865

    Article  PubMed  Google Scholar 

  35. La Padula S, Hersant B, Noel W, Niddam J, Hermeziu O, Bouhassira J, Bosc R, Meningaud JP (2016) Use of the retrograde limb of the internal mammary vein to avoid venous congestion in DIEP flap breast reconstruction: Further evidences of a reliable and timesparing procedure. Microsurgery 36(6):447–452

    Article  PubMed  Google Scholar 

  36. Hersant B, Werkoff G, Sawan D, Sidahmed-Mezi M, Bosc R, La Padula S, Kalsoum S, Ouidir N, Meningaud JP, Belkacemi Y (2020) Carbon dioxide laser treatment for vulvovaginal atrophy in women treated for breast cancer: Preliminary results of the feasibility EPIONE trial. Ann Chir Plast Esthet 65(4):e23–e31. https://doi.org/10.1016/j.anplas.2020.05.002. (Epub 2020 Jun 5)

    Article  CAS  PubMed  Google Scholar 

  37. La Padula S, Hersant B, Helynck P, Mezi SidAhmed M, Meningaud JP (2020) Proposal of a noninvasive method to reduce injection-related bruising in aesthetic medicine: transillumination. Aesthet Plast Surg 44(2):530–534. https://doi.org/10.1007/s00266-019-01447-w

    Article  Google Scholar 

  38. Giroux PA, Hersant B, SidAhmed-Mezi M, Pizza C, La Padula S, Meningaud JP (2019) The outcomes assessment of the plasma blade technology in upper blepharoplasties: a prospective study on a series of 25 patients. Aesthet Plast Surg 43(4):948–955. https://doi.org/10.1007/s00266-019-01360-2. (Epub 2019 Mar 29)

    Article  Google Scholar 

  39. La Padula S, Hersant B, Meningaud JP, D’Andrea F (2018) Use of autologous fat graft and fractiononal co2 laser to optimize the aesthetic and functional results in patients with severe burn outcomes of the face. J Stomatol Oral Maxillofac Surg. 119(4):279–283

    Article  PubMed  Google Scholar 

  40. Hersant B, Jabbour S, Noel W, Benadiba L, La Padula S, SidAhmed-Mezi M, Meningaud JP (2018) Labia majora augmentation combined with minimal labia minora resection: a safe and global approach to the external female genitalia. Ann Plast Surg 80(4):323–327

    Article  CAS  PubMed  Google Scholar 

  41. Hersant B, Niddam J, Picard F, Bouhassira J, La Padula S, Bosc R, Meningaud JP (2016) Platelet-rich plasma with basic fibroblast growth factor for treatment of wrinkles and depressed areas of the skin. Plast Reconstr Surg 137(6):1048–1049

    Article  Google Scholar 

  42. Eyraud Q, La Padula S, Pizza C, Hersant B, Meningaud JP (2021) Carboxytherapy, subcutaneous injections of carbon dioxide in the management of infraorbital dark circles: a reliable and effective procedure. J Craniomaxillofac Surg 49(8):670–674. https://doi.org/10.1016/j.jcms.2021.01.028. (Epub 2021 Feb 5 PMID: 33612408)

    Article  PubMed  Google Scholar 

  43. Azuelos A, SidAhmed-Mezi M, La Padula S, Aboud C, Meningaud JP, Hersant B (2019) High-intensity focused ultrasound: a satisfactory noninvasive procedure for neck rejuvenation. Aesthet Surg J 39(8):NP343–NP351. https://doi.org/10.1093/asj/sjz093. (PMID: 30923813)

    Article  PubMed  Google Scholar 

  44. La Padula S, Hersant B, Noel W, Meningaud JP (2018) Liposuction-assisted four pedicle-based breast reduction (LAFPBR): a new safer technique of breast reduction for elderly patients. J Plast Reconstr Aesthet Surg 71(5):691–698. https://doi.org/10.1016/j.bjps.2018.01.006. (Epub 2018 Jan 31 PMID: 29433957)

    Article  PubMed  Google Scholar 

Download references

Funding

None

Author information

Authors and Affiliations

  1. Department of Plastic, Reconstructive and Maxillo facial Surgery, Henri Mondor Hospital, University Paris XII, 51 Avenue du Maréchal de Lattre de Tassigny, 94000, Créteil, France

    Edoardo Coiante, Ilyes Hadji, Giorgio Lo Giudice, Chiara Pizza, Mounia SidAhmed-Mezi, Jean Paul Meningaud, Barbara Hersant & Simone La Padula

  2. Department of Plastic and Reconstructive Surgery, Università degli studi di Napoli Federico II, Via Pansini 5, 80131, Napoli, Italy

    Rosita Pensato, Francesco D’Andrea & Simone La Padula

  3. 50 rue Saint, 75011 PARIS, Sébastien, France

    Simone La Padula

Authors
  1. Edoardo Coiante
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rosita Pensato
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ilyes Hadji
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Giorgio Lo Giudice
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chiara Pizza
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mounia SidAhmed-Mezi
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Francesco D’Andrea
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jean Paul Meningaud
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Barbara Hersant
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Simone La Padula
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Simone La Padula.

Ethics declarations

Conflict of interest

The authors declare that they have no conflicts of interest to disclose

Ethical Approval

Ethical Approval was given, by FRENCH institutional committee and the relevant Judgment’s Reference Number is 2021-A01789-54.

Human Participants

All procedures in the study involving human participants have been performed in accordance with the ethical standards of institutional and/or national research committees and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed Consent

All patients taking part in the study signed a written informed consent.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Coiante, E., Pensato, R., Hadji, I. et al. Assessment of the Efficacy of Cryolipolysis on Abdominal Fat Deposits: A Prospective Study. Aesth Plast Surg 47, 2679–2686 (2023). https://doi.org/10.1007/s00266-023-03369-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00266-023-03369-0

Keywords

Search

Navigation