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Cryolipolysis Does not Modify the Behavior and Recovery of Cardiac Autonomic Modulation

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  • Body Contouring
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Abstract

The desire to reduce and remodel undesirable fatty deposits has increased the popularity and use of aesthetic procedures, among them, cryolipolysis. However, repercussions on the autonomic nervous system must be considered, since the decrease in cutaneous body temperature can have repercussions on sympathetic and parasympathetic components. The aim was to evaluate the behavior of cardiac autonomic modulation during and after a single application of cryolipolysis. A single-arm, prospective interventional study evaluated data from 13 women with a mean age of 22.38 ± 2.95 years, who had an accumulation of abdominal fat of at least 1.5 mm, were using oral contraceptives, and were sedentary. A professional applied cryolipolysis in a single 40-min session. RR intervals were collected by means of a cardiofrequency meter, at rest prior to the technique for 10 min, during the performance of the technique, and immediately after the end of the technique for a period of 50 min. Heart rate variability (HRV) analysis was performed using time, frequency, and Poincaré plot indices. For the mean RR, SDNN, rMSSD, SD1, SD2, and LF [ms2] indices, the values increased during the execution of cryolipolysis when compared to rest. In the recovery period, increases in the mean values of the RR, SDNN, rMSSD, SD1, SD2, HF [ms2], LF [nu], and HF [nu] indices were also observed when compared to the baseline moment. Both during the technique and in the recovery period, there were changes in the behavior of HRV characterized by an increase in global and vagal indices.

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References

  1. Klein KB, Bachelor EP, Becker EV, Bowes LE (2017) Multiple same day cryolipolysis treatments for the reduction of subcutaneous fat are safe and do not affect serum lipid levels or liver function tests. Lasers Surg Med 49:640–644

    PubMed  PubMed Central  Google Scholar 

  2. Zelickson BD, Burns AJ, Kilmer SL (2015) Cryolipolysis for safe and effective inner thigh fat reduction. Lasers Surg Med 47:120–127

    PubMed  PubMed Central  Google Scholar 

  3. Klein KB, Zelickson B, Riopelle JG, Okamoto E, Bachelor EP, Harry RS, Preciado JA (2009) Non-invasive Cryolipolysis for subcutaneous fat reduction does not affect serum lipid levels or liver function tests. Lasers Surg Med 41:785–790

    PubMed  Google Scholar 

  4. Avram MM, Harry RS (2009) Cryolipolysis for subcutaneous fat layer reduction. Lasers Sur Med 41:703–708

    Google Scholar 

  5. D’Arcy MS (2019) Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int 43:582–592

    PubMed  Google Scholar 

  6. Oliveira PS, de Carvalho MA, Braga MA, Leite MMP, Medrado AP (2019) Comparative thermographic analysis at pre- and post cryolipolysis treatment: clinical case report. J Cosmet Dermatol 18:136–141

    PubMed  Google Scholar 

  7. Meyer PF, Silva RMV, Oliveira G, Tavares MAS, Medeiros ML, Andrada CP, Neto LGA (2016) Effects of cryolipolysis on abdominal adiposity. Case Rep Dermatol Med 2016:1–7

    Google Scholar 

  8. Meyer PF, Furtado ACG, Morais SFT, Araujo Neto LG, Silva RMV, Marcel R, Medeiros ML, Queiroz CAM (2017) Effects of cryolipolysis on abdominal adiposity of women. Cryo Lett 38:379–386

    Google Scholar 

  9. Wanitphakdeedecha R, Sathaworawong A, Manuskiatti W (2015) The efficacy of cryolipolysis treatment on arms and inner thighs. Lasers Med Sci 30:2165–2169

    PubMed  PubMed Central  Google Scholar 

  10. Silverthorn DU (2003) Fisiologia humana: uma abordagem integrada. 2 ed, Manole, São Paulo.

  11. Guyton AC, Hall JE (2006) Fisiologia Médica, 11th edn. Elsevier, Rio de Janeiro

    Google Scholar 

  12. Few J, Saltz R, Beaty M, Kellly M, Movassaghi K, Marcus KA, Sieber D, Bruns AJ, Sangha S (2020) Cryolipolysis: clinical best practices and others nonclinical considerations. Aesthet Surg J Open Forum. https://doi.org/10.1093/asjof/ojaa010

    Article  PubMed  PubMed Central  Google Scholar 

  13. Fonseca-Alaniz MH, Takada J, Alonso-Vale MIC, Lima FB (2006) O tecido adiposo como centro regulador do metabolismo. Arq Bras Endocrinol Metab 50:216–229

    Google Scholar 

  14. Rossi RC, Vanderlei FM, Bernardo AF, Souza NM, Gonçalves ACCR, Ramos EMC, Pastre CM, Abreu LC, Vanderlei LCM (2014) Effect of pursed-lip breathing in patients with COPD: linear and nonlinear analysis of cardiac autonomic modulation. COPD 11:39–45

    PubMed  Google Scholar 

  15. Barreto GSC, Vanderlei FM, Vanderlei LCM, Leite AJM (2016) Impact of malnutrition on cardiac autonomic modulation in children. J Pediatr 92:638–644

    Google Scholar 

  16. Silva AKF, Barbosa MPCR, Vanderlei FM, Christofaro DGD, Vanderlei LCM (2016) Application of heart rate variability in diagnosis and prognosis of individuals with diabetes mellitus: systematic review. Ann Noninvasive Electrocardiol 21:233–235

    Google Scholar 

  17. Ferreira LL, Vanderlei LCM, Guida HL, Abreu LC, Garner DM, Vanderlei FM, Ferreira C, Valenti VE (2015) Response of cardiac autonomic modulation after a single exposure to musical auditory stimulation. Noise Health 17:108–115

    PubMed  PubMed Central  Google Scholar 

  18. Tsuji H, Larson MG, Venditti FJ, Manders ES, Evans JC, Feldman CL, Levy D (1996) Impact of reduced heart rate variability on risk for cardiac events. Framingham Heart Study Circ 94:2850–2855

    CAS  Google Scholar 

  19. Pardini R, Matsudo S, Araújo T, Matsudo V, Andrade E, Braggion G, Andrade D, Oliveira L, Figueira A Jr, Raso V (2001) Validação do questionário internacional de nível de atividade física (IPAQ–versão 6): estudo piloto em adultos jovens brasileiros. Rev Bras Ciên e Mov 9:45–51

    Google Scholar 

  20. Eldesoky MTM, Abutaleb EEM, Mousa GSM (2016) Ultrasound cavitation versus cryolipolysis for non-invasive body contouring. Australas J Dermatol 57:288–293

    Google Scholar 

  21. Jackson AS, Pollock ML, Ward A (1980) Generalized equations for predicting body density of women. Med Sci Sports Exerc 12:175–181

    CAS  PubMed  Google Scholar 

  22. Derrick CD, Shridharani SM, Broyles JM (2015) The safety and efficacy of cryolipolysis: a systematic review of available literature. Aesthet Surg J 35:830–836

    PubMed  Google Scholar 

  23. Cocoon Medical. Manual de especificações técnicas do aparelho CoolTech. Barcelona, Spain. 2015.

  24. Giles D, Draper N, Neil W (2016) Validity of the polar V800 heart rate monitor to measure RR intervals at rest. Eur J Appl Physiol 116:563–571

    PubMed  Google Scholar 

  25. Catai AM, Pastre CM, Godoy MF, Silva ED, Takahashi ACM, Vanderlei LCM (2020) Heart rate variability: Are you using it properly? Standardisation checklist of procedures. Braz J Phys Ther 24:91–102

    PubMed  Google Scholar 

  26. Barbosa MPCR, Netto Júnior J, Cassemiro BM, Bernardo AFB, Silva AKF, Vanderlei FM, Pastre CM, Vanderlei LCM (2016) Effects of functional training on geometric indices of heart rate variability. J Sport Health Sci 5:183–189

    Google Scholar 

  27. Tarvainen MP, Niskanen JP, Lipponen JÁ, Ranta-Aho PO, Karjalainen PA (2014) Kubios HRV—heart rate variability analysis software. Comput Methods Progr Biomed 113:210–220

    Google Scholar 

  28. Goudman L, Brouns R, Linderoth B, Moens M (2021) Effects of spinal cord stimulation on heart rate variability in patients with failed back surgery syndrome: comparison between a 2-lead ecg and a wearable device. Neuromodulation 24:512–519

    PubMed  Google Scholar 

  29. Task Force of the European Society of Cardiology of the North American Society of pacing electrophysiology (1996) Heart rate variability standards of measurement, physiological interpretation and clinical use. Circulation 93:1043–1065

    Google Scholar 

  30. WHO | Obesity and overweight. WHO. 2016.

  31. Meyer PF, Silva JDC, Vasconcelos LS, Carreiro EM, Silva RMV (2018) Cryolipolysis: patient selection and special considerations. Clin Cosmet Investig Dermatol 11:499–503

    PubMed  PubMed Central  Google Scholar 

  32. Majdabadi A, Abazari M (2016) Simulation of cryolipolysis as a novel method for noninvasive fat layer reduction. Turk J Med Sci 46:1682–1687

    CAS  PubMed  Google Scholar 

  33. Pereira JX, Cavalcante Y, Wanzeler de Oliveira R (2017) The role of inflammation in adipocytolytic nonsurgical esthetic procedures for body contouring. Clin Cosmet Investig Dermatol 10:57–66

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Hwang IC, Kim KK, Lee KR (2020) Cryolipolysis-induced adbominal fat change: Split-body trials. PLoS ONE 15:e0242782

    CAS  PubMed  PubMed Central  Google Scholar 

  35. Rotunda AM (2009) Injectable treatments for adipose tissue: terminology, mechanism and tissue interaction. Lasers Surg Med 41:714–720

    PubMed  Google Scholar 

  36. Ingargiola MJ, Motakef S, Chung MT, Vasconez HC, Sasaki GH (2015) Cryolipolysis for fat reduction and body contouring: safety and efficacy of current treatment paradigms. Plast Reconstr Surg 135:1581–1590

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Krueger N, Mai SV, Luebberding S, Sadick NS (2014) Cryolipolysis for noninvasive body contouring: clinical efficacy and patient satisfaction. Clin Cosmet Investig Dermatol 7:201–205

    PubMed  PubMed Central  Google Scholar 

  38. Manstein D, Laubach H, Watanabe K, Farinelli W, Zurakowski D, Anderson RR (2008) Selective cryolysis: a novel method of non-invasive fat removal. Lasers Surg Med 40:595–604

    PubMed  Google Scholar 

  39. Nelson AA, Wasserman D, Avram MM (2009) Cryolipolysis for reduction of excess adipose tissue. Semin Cutan Med Surg 28:244–249

    CAS  PubMed  Google Scholar 

  40. Brightman L, Geronemus R (2011) Can second treatment enhance clinical results in cryolipolysis? Cosmetic Derm 24:85–88

    Google Scholar 

  41. Manstein DL, Laubach H, Watanabe K, Farinelli W, Zurakowski D, Anderson RR (2008) Selective cryolysis: a novel method of non- -invasive fat removal. Lasers Surg Med 40:595–604

    PubMed  Google Scholar 

  42. Boey GE, Wasilenchuk JL (2014) Enhanced clinical outcome with manual massage following cryolipolysis treatment: a 4-month study of safety and efficacy. Lasers Surg Med 46:20–26

    PubMed  Google Scholar 

  43. Vanderlei LCM, Pastre CM, Hoshi RA, Carvalho TD, Godoy MF (2009) Noções básicas de variabilidade da frequência cardíaca e sua aplicabilidade clínica. Rev Bras Cir Cardiovasc 24:205–217

    PubMed  Google Scholar 

  44. Malik M, Camm AJ (1994) Heart rate variability and clinical cardiology. Br Heart J 71:3–6

    CAS  PubMed  PubMed Central  Google Scholar 

  45. Hayano J, Skakibara Y, Yamada M, Kamiya T, Yamada M (1991) Accuracy of assessment of cardiac vagal tone by heart rate variability in normal subjects. Am J Cardiol 76:199–204

    Google Scholar 

  46. Shaffer F, Ginsberg JP (2017) An overview of heart rate variability metrics and norms. Front Public Health 5:258

    PubMed  PubMed Central  Google Scholar 

  47. Oliveira C, Silveira EA, Rosa L, Santos A, Rodrigues AP, Mendonça C, Silva L, Rebelo AC (2020) Risk factors associated with cardiac autonomic modulation in obese individuals. J Obes 2020:7185249

    PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Programa de Pós-Graduação em Ciências da Saúde, Universidade do Oeste Paulista, Presidente Prudente, SP, Brazil

    Ana Clara Campagnolo Real Gonçalves Toledo

  2. Programa de Pós-Graduação em Fisioterapia, Universidade Estadual Paulista (FCT/UNESP), Presidente Prudente, SP, Brazil

    Allysiê Priscilla de Souza Cavina

  3. Graduada em Fisioterapia, Universidade Estadual Paulista (FCT/UNESP), Presidente Prudente, SP, Brazil

    Isadora Stefen Seixas, Letícia Rosa de Jesus & Maria Eduarda Leonel Silva

  4. Docente do curso de Estética e Cosmética, Universidade do Oeste Paulista, Presidente Prudente, SP, Brazil

    Ana Clara Campagnolo Real Gonçalves Toledo & Bruna Garcia Corral de Araújo

  5. Programa de Pós-Graduação em Ciências do Movimento, Universidade Estadual Paulista (FCT/UNESP), Presidente Prudente, SP, Brazil

    Franciele Marques Vanderlei

  6. Departamento de Fisioterapia, Faculdade de Ciências e Tecnologia – FCT/UNESP, Presidente Prudente, SP, Brazil

    Franciele Marques Vanderlei

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  1. Ana Clara Campagnolo Real Gonçalves Toledo
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Correspondence to Franciele Marques Vanderlei.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Institutional Ethics Committee approved all procedures (CAAE: 93797118.9.0000.5402).

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Toledo, A.C.C.R.G., de Souza Cavina, A.P., Seixas, I.S. et al. Cryolipolysis Does not Modify the Behavior and Recovery of Cardiac Autonomic Modulation. Aesth Plast Surg 46, 265–275 (2022). https://doi.org/10.1007/s00266-021-02522-x

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  • DOI: https://doi.org/10.1007/s00266-021-02522-x

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