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Platelet-Rich Plasma Facial Rejuvenation: Myth or Reality?

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  • Non-Surgical Aesthetic
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Abstract

Platelet-rich plasma (PRP) rejuvenation’s efficacy has been reported by numerous uncontrolled clinical case studies of inconsistent quality rather than large randomized and placebo-controlled trials. It was suggested that PRP could be considered as a valid anti-aging and rejuvenation treatment modality. The current literature review summarizes available evidence so far described in the literature with special critical attention to higher quality comparative studies published over the last 10 years. The few studies that could be retrieved and included in this review documented less favorable results. So far, there is no international consensus on clinical PRP use for esthetic rejuvenation. Whether a mix of growth factors does in fact generate a clinically significant more youthful look and whether PRP injections result in comparable or better rejuvenation than what can be expected from other simpler non-surgical modalities.

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References

  1. Wang X, Yang Y, Zhang Y, Miron RJ (2019) Fluid platelet-rich fibrin stimulates greater dermal skin fibroblast cell migration, proliferation, and collagen synthesis when compared to platelet-rich plasma. J Cosmet Dermatol 18(6):2004–2010

    PubMed  Google Scholar 

  2. Kaushik A, Kumaran MS (2020) Platelet-rich plasma: the journey so far! Indian Dermatol Online J 11(5):685

    PubMed  PubMed Central  Google Scholar 

  3. Schoenberg E, Hattier G, Wang JV, Saedi N (2020) Platelet-rich plasma for facial rejuvenation: an early examination. Clin Dermatol 38(2):251–253

    PubMed  Google Scholar 

  4. Zhang M, Park G, Zhou B, Luo D (2018) Applications and efficacy of platelet-rich plasma in dermatology: a clinical review. J Cosmet Dermatol 17(5):660–665

    PubMed  Google Scholar 

  5. Samadi P, Sheykhhasan M, Khoshinani HM (2019) The use of platelet-rich plasma in aesthetic and regenerative medicine: a comprehensive review. Aesthetic Plast Surg 43(3):803–814

    PubMed  Google Scholar 

  6. Hausauer AK, Humphrey S (2020) The physician’s guide to platelet-rich plasma in dermatologic surgery part II: clinical evidence. Dermatol Surg 46(4):447–456

    CAS  PubMed  Google Scholar 

  7. Abu-Ghname A, Perdanasari AT, Davis MJ, Reece EM (2019) Platelet-rich plasma: principles and applications in plastic surgery. Seminars in plastic surgery. Thieme Medical Publishers, New York

    Google Scholar 

  8. Marx RE (2001) Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent 10(4):225–228

    CAS  PubMed  Google Scholar 

  9. Gupta S, Paliczak A, Delgado D (2021) Evidence-based indications of platelet-rich plasma therapy. Exp Rev Hematol 14(1):97–108

    CAS  Google Scholar 

  10. Kassir M, Kroumpouzos G, Puja P, Katsambas A, Galadari H, Lotti T et al (2020) Update in minimally invasive periorbital rejuvenation with a focus on platelet-rich plasma: a narrative review. J Cosmet Dermatol 19(5):1057–1062

    PubMed  Google Scholar 

  11. Peng GL (2019) Platelet-rich plasma for skin rejuvenation: facts, fiction, and pearls for practice. Facial Plast Surg Clinics 27(3):405–411

    Google Scholar 

  12. Araco A (2019) A prospective study comparing topic platelet-rich plasma versus placebo on reducing superficial perioral wrinkles and restore dermal matrix. J Cosmet Laser Ther 21(6):309–15

    PubMed  Google Scholar 

  13. Draelos ZD, Rheins LA, Wootten S, Kellar RS, Diller RB (2019) Pilot study: autologous platelet-rich plasma used in a topical cream for facial rejuvenation. J Cosmet Dermatol 18(5):1348–1352

    PubMed Central  Google Scholar 

  14. Hausauer AK, Humphrey S (2020) The physician’s guide to platelet-rich plasma in dermatologic surgery part I: definitions, mechanisms of action, and technical specifications. Dermatol Surg 46(3):348–357

    CAS  PubMed  Google Scholar 

  15. Lei X, Xu P, Cheng B (2019) Problems and solutions for platelet-rich plasma in facial rejuvenation: a systematic review. Aesthetic Plast Surg 43(2):457–469

    PubMed  Google Scholar 

  16. Elghblawi E (2018) Platelet-rich plasma, the ultimate secret for youthful skin elixir and hair growth triggering. J Cosmet Dermatol 17(3):423–430

    PubMed  Google Scholar 

  17. Yuksel EP, Sahin G, Aydin F, Senturk N, Turanli AY (2014) Evaluation of effects of platelet-rich plasma on human facial skin. J Cosmet Laser Ther 16(5):206–208

    PubMed  Google Scholar 

  18. Kumaran MS (2014) Platelet-rich plasma in dermatology: boon or a bane? Indian J Dermatol Venereol Leprol 80(1):5

    PubMed  Google Scholar 

  19. Cho EB, Park GS, Park SS, Jang YJ, Kim KH, Kim KJ et al (2019) Effect of platelet-rich plasma on proliferation and migration in human dermal fibroblasts. J Cosmet Dermatol 18(4):1105–1112

    PubMed  Google Scholar 

  20. Magalon J, Chateau A, Bertrand B, Louis M, Silvestre A, Giraudo L et al (2016) DEPA classification: a proposal for standardising PRP use and a retrospective application of available devices. BMJ Open Sport Exerc Med 2(1):e000060

    CAS  PubMed  PubMed Central  Google Scholar 

  21. Lin J, Sclafani AP (2018) Platelet-rich plasma for skin rejuvenation and tissue fill. Facial Plast Surg Clin 26(4):439–446

    Google Scholar 

  22. Sclafani AP, Azzi J (2015) Platelet preparations for use in facial rejuvenation and wound healing: a critical review of current literature. Aesthetic Plast Surg 39(4):495–505

    PubMed  Google Scholar 

  23. Ehrenfest DMD, Rasmusson L, Albrektsson T (2009) Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte-and platelet-rich fibrin (L-PRF). Trends Biotechnol 27(3):158–167

    Google Scholar 

  24. Lin M-Y, Lin C-S, Hu S, Chung W-H (2020) Progress in the use of platelet-rich plasma in aesthetic and medical dermatology. J Clin Aesth Dermatol 13(8):28

    Google Scholar 

  25. Tekin L (2018) Re: histologic evidence of new collagen formulation using platelet rich plasma in skin rejuvenation: a prospective controlled clinical study. Ann Dermatol 30(1):110

    PubMed  Google Scholar 

  26. Emer J (2019) Platelet-rich plasma (PRP): current applications in dermatology. Skin Therapy Lett. 24(5):1–6

    PubMed  Google Scholar 

  27. Kawase T, Okuda K (2018) Comprehensive quality control of the regenerative therapy using platelet concentrates: the current situation and prospects in Japan. BioMed Res Int 2018:1–10

    Google Scholar 

  28. Leo MS, Kumar AS, Kirit R, Konathan R, Sivamani RK (2015) Systematic review of the use of platelet-rich plasma in aesthetic dermatology. J Cosmet Dermatol 14(4):315–323

    PubMed  Google Scholar 

  29. DeLong JM, Russell RP, Mazzocca AD (2012) Platelet-rich plasma: the PAW classification system. Arthrosc J Arthrosc Relat Surg 28(7):998–1009

    Google Scholar 

  30. Chen J, Jiang H (2020) A comprehensive review of concentrated growth factors and their novel applications in facial reconstructive and regenerative medicine. Aesthetic Plast Surg 44(3):1047–1057

    PubMed  Google Scholar 

  31. Godfrey L, Martínez-Escribano J, Roo E, Pino A, Anitua E (2020) Plasma rich in growth factor gel as an autologous filler for facial volume restoration. J Cosmet Dermatol 19(10):2552–2559

    PubMed  Google Scholar 

  32. Jiménez Gómez N, Pino Castresana A, Segurado Miravalles G, Truchuelo Díez M, Troya Estavillo M, Anitua Aldecoa E et al (2019) Autologous platelet-rich gel for facial rejuvenation and wrinkle amelioration: a pilot study. J Cosmet Dermatol 18(5):1353–1360

    Google Scholar 

  33. Fedyakova E, Pino A, Kogan L, Eganova C, Troya M, Anitua E (2019) An autologous protein gel for soft tissue augmentation: in vitro characterization and clinical evaluation. J Cosmet Dermatol 18(3):762–772

    PubMed  Google Scholar 

  34. Sclafani AP, McCormick SA (2012) Induction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix. Arch Facial Plast Surg 14(2):132–136

    PubMed  Google Scholar 

  35. Sclafani AP (2011) Safety, efficacy, and utility of platelet-rich fibrin matrix in facial plastic surgery. Arch Facial Plast Surg 13(4):247–251

    PubMed  Google Scholar 

  36. Hassan H, Quinlan DJ, Ghanem A (2020) Injectable platelet-rich fibrin for facial rejuvenation: a prospective, single-center study. J Cosmet Dermatol 19(12):3213–3221

    PubMed  Google Scholar 

  37. Weibrich G, Kleis WK, Hafner G, Hitzler WE (2002) Growth factor levels in platelet-rich plasma and correlations with donor age, sex, and platelet count. J Cranio-Maxillofac Surg 30(2):97–102

    Google Scholar 

  38. Görgü M, Gökkaya A, Karanfil E (2021) What should be adequate PRP dose for an effective treatment? An in-vitro experimental study on the skin. Aesthet Surg J. https://doi.org/10.1093/asj/sjab043

    Article  PubMed  Google Scholar 

  39. Weibrich G, Hansen T, Kleis W, Buch R, Hitzler W (2004) Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration. Bone 34(4):665–671

    CAS  PubMed  Google Scholar 

  40. Giusti I, Rughetti A, D’Ascenzo S, Millimaggi D, Pavan A, Dell’Orso L et al (2009) Identification of an optimal concentration of platelet gel for promoting angiogenesis in human endothelial cells. Transfusion 49(4):771–778

    PubMed  Google Scholar 

  41. Sevilla GP, Dhurat RS, Shetty G, Kadam PP, Totey SM (2015) Safety and efficacy of growth factor concentrate in the treatment of nasolabial fold correction: split face pilot study. Indian J Dermatol 60(5):520

    PubMed  PubMed Central  Google Scholar 

  42. Mishra A, Tummala P, King A, Lee B, Kraus M, Tse V et al (2009) Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation. Tissue Eng Part C Methods 15(3):431–435

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Kim DH, Je YJ, Kim CD, Lee YH, Seo YJ, Lee JH et al (2011) Can platelet-rich plasma be used for skin rejuvenation? Evaluation of effects of platelet-rich plasma on human dermal fibroblast. Ann Dermatol 23(4):424

    CAS  PubMed  PubMed Central  Google Scholar 

  44. Berndt S, Turzi A, Pittet-Cuénod B, Modarressi A (2019) Autologous platelet-rich plasma (CuteCell PRP) safely boosts in vitro human fibroblast expansion. Tissue Eng Part A 25(21–22):1550–1563

    CAS  PubMed  Google Scholar 

  45. Owczarczyk-Saczonek A, Wygonowska E, Budkiewicz M, Placek W (2019) Serum sickness disease in a patient with alopecia areata and Meniere’disease after PRP procedure. Dermatol Ther 32(2):e12798

    PubMed  Google Scholar 

  46. Badran KW, Nabili V (2018) Lasers, microneedling, and platelet-rich plasma for skin rejuvenation and repair. Fac Plast Surg Clin 26(4):455–468

    Google Scholar 

  47. Willemsen JC, van der Lei B, Vermeulen KM, Stevens HP (2014) The effects of platelet-rich plasma on recovery time and aesthetic outcome in facial rejuvenation: preliminary retrospective observations. Aesthet Plast Surg 38(5):1057–1063

    Google Scholar 

  48. Bulam H, Ayhan S, Sezgin B, Zinnuroglu M, Konac E, Varol N et al (2015) The inhibitory effect of platelet-rich plasma on botulinum toxin type-A: an experimental study in rabbits. Aesthet Plast Surg 39(1):134–140

    Google Scholar 

  49. Lee ZH, Sinno S, Poudrier G, Motosko CC, Chiodo M, Saia W et al (2019) Platelet rich plasma for photodamaged skin: a pilot study. J Cosmet Dermatol 18(1):77–83

    PubMed  Google Scholar 

  50. Fabi S, Sundaram H (2014) The potential of topical and injectable growth factors and cytokines for skin rejuvenation. Fac Plast Surg 30(02):157–171

    CAS  Google Scholar 

  51. Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6(7):e1000097

    PubMed  PubMed Central  Google Scholar 

  52. ASPS Evidence Rating Scales [Available from: www.plasticsurgery.org/documents/medical-professionals/health-policy/evidence-practice/ASPS-Rating-Scale-March-2011.pdf.

  53. Kang BK, Shin MK, Lee JH, Kim NI (2014) Effects of platelet-rich plasma on wrinkles and skin tone in Asian lower eyelid skin: preliminary results from a prospective, randomised, split-face trial. Eur J Dermatol 24(1):100–101

    PubMed  Google Scholar 

  54. Kang BK, Lee JH, Shin MK, Kim NI (2013) Infraorbital rejuvenation using PRP (platelet-rich plasma): a prospective, randomized, split-face trial. J Am Acad Dermatol 68:24

    Google Scholar 

  55. Abuaf OK, Yildiz H, Baloglu H, Bilgili ME, Simsek HA, Dogan B (2016) Histologic evidence of new collagen formulation using platelet rich plasma in skin rejuvenation: a prospective controlled clinical study. Ann Dermatol 28(6):718

    CAS  PubMed  PubMed Central  Google Scholar 

  56. Gawdat HI, Tawdy AM, Hegazy RA, Zakaria MM, Allam RS (2017) Autologous platelet-rich plasma versus readymade growth factors in skin rejuvenation: a split face study. J Cosmet Dermatol 16(2):258–264

    PubMed  Google Scholar 

  57. Alam M, Hughart R, Champlain A, Geisler A, Paghdal K, Whiting D et al (2018) Effect of platelet-rich plasma injection for rejuvenation of photoaged facial skin: a randomized clinical trial. JAMA Dermatol 154(12):1447–1452

    PubMed  PubMed Central  Google Scholar 

  58. Hu S, Bassiri-Tehrani M, Abraham MT (2020) The effect of platelet-rich fibrin matrix on skin rejuvenation: a split-face comparison. Aesthet Surg J. https://doi.org/10.1093/asj/sjaa244

    Article  PubMed  Google Scholar 

  59. Neinaa YMEH, Hodeib AAEH, Morquos MM, Elgarhy LH (2020) Platelet-poor plasma gel vs platelet-rich plasma for infraorbital rejuvenation: a clinical and dermoscopic comparative study. Dermatol Ther 33(6):e14255

    CAS  PubMed  Google Scholar 

  60. da Silva LQ, Cancela RBB, de Lima Montalvão SA, Huber SC, Vieira-Damiani G, Triglia RM et al (2021) The effect of lyophilized platelet rich-plasma on skin aging: a non-randomized, controlled, pilot trial. Arch Dermatol Res. https://doi.org/10.1007/s00403-021-02186-2

    Article  PubMed  Google Scholar 

  61. Hersant B, SidAhmed-Mezi M, Aboud C, Niddam J, Levy S, Mernier T et al (2021) Synergistic effects of autologous platelet-rich plasma and hyaluronic acid injections on facial skin rejuvenation. Aesthet Surg J. https://doi.org/10.1093/asj/sjab061

    Article  PubMed  Google Scholar 

  62. Rivers JK (2014) Platelet-rich plasma: should we wait for the verdict? SAGE Publications Sage CA, Los Angeles CA

    Google Scholar 

  63. Redaelli A, Romano D, Marciano A (2010) Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol JDD 9(5):466–472

    PubMed  Google Scholar 

  64. Cameli N, Mariano M, Cordone I, Abril E, Masi S, Foddai ML (2017) Autologous pure platelet-rich plasma dermal injections for facial skin rejuvenation: clinical, instrumental, and flow cytometry assessment. Dermatol Surg 43(6):826–835

    CAS  PubMed  Google Scholar 

  65. Elnehrawy NY, Ibrahim ZA, Eltoukhy AM, Nagy HM (2017) Assessment of the efficacy and safety of single platelet-rich plasma injection on different types and grades of facial wrinkles. J Cosmet Dermatol 16(1):103–111

    PubMed  Google Scholar 

  66. Atiyeh BS, Chahine F (2020) Evidence-based efficacy of high-intensity focused ultrasound (HIFU) in aesthetic body contouring. Aesthet Plast Surg 45(2):570–578

    Google Scholar 

  67. Pavlović MD, Loubser MD (2019) Use of platelet-rich plasma injection for rejuvenation of photoaged facial skin? JAMA Dermatol 155(6):755

    PubMed  Google Scholar 

  68. Atiyeh BS, Fadul R, Chahine F (2020) Cryolipolysis (CLL) for reduction of localized subcutaneous fat: review of the literature and an evidence-based analysis. Aesthet Plast Surg 44(6):2163–2172

    Google Scholar 

  69. Mehryan P, Zartab H, Rajabi A, Pazhoohi N, Firooz A (2014) Assessment of efficacy of platelet-rich plasma (PRP) on infraorbital dark circles and crow’s feet wrinkles. J Cosmet Dermatol 13(1):72–78

    PubMed  Google Scholar 

  70. Du R, Lei T (2020) Effects of autologous platelet-rich plasma injections on facial skin rejuvenation. Exp Ther Med 19(4):3024–3030

    CAS  PubMed  PubMed Central  Google Scholar 

  71. Everts PA, Pinto PC, Girão L (2019) Autologous pure platelet-rich plasma injections for facial skin rejuvenation: biometric instrumental evaluations and patient-reported outcomes to support antiaging effects. J Cosmet Dermatol 18(4):985–995

    PubMed  Google Scholar 

  72. Aust M, Pototschnig H, Jamchi S, Busch K-H (2018) Platelet-rich plasma for skin rejuvenation and treatment of actinic elastosis in the lower eyelid area. Cureus. https://doi.org/10.7759/cureus.2999

    Article  PubMed  PubMed Central  Google Scholar 

  73. Atiyeh BS, Ibrahim AE, Dibo SA (2008) Cosmetic mesotherapy: between scientific evidence, science fiction, and lucrative business. Aesthet Plast Surg 32(6):842–849

    Google Scholar 

  74. Atiyeh BS, Abou Ghanem O, Chahine F (2020) Microneedling: percutaneous collagen induction (PCI) therapy for management of scars and photoaged skin—scientific evidence and review of the literature. Aesthet Plast Surg 45(1):296–308

    Google Scholar 

  75. Charles-de-Sá L, Gontijo-de-Amorim NF, Takiya CM, Borojevic R, Benati D, Bernardi P et al (2018) Effect of use of platelet-rich plasma (PRP) in skin with intrinsic aging process. Aesthet Surg J 38(3):321–328

    PubMed  Google Scholar 

  76. McLeod MD, Austen WG Jr (2018) Commentary on: effect of use of platelet-rich plasma (PRP) in skin with intrinsic aging process. Aesthet Surg J 38(3):329–331

    PubMed  Google Scholar 

  77. Frautschi RS, Hashem AM, Halasa B, Cakmakoglu C, Zins JE (2017) Current evidence for clinical efficacy of platelet rich plasma in aesthetic surgery: a systematic review. Aesthet Surg J 37(3):353–362

    PubMed  Google Scholar 

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  1. Division of Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon

    Bishara Atiyeh, Ahmad Oneisi & Fadi Ghieh

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  1. Bishara Atiyeh
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  2. Ahmad Oneisi
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Atiyeh, B., Oneisi, A. & Ghieh, F. Platelet-Rich Plasma Facial Rejuvenation: Myth or Reality?. Aesth Plast Surg 45, 2928–2938 (2021). https://doi.org/10.1007/s00266-021-02300-9

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