Abstract
Background
Freckles are typical epidermal pigmented disorders that occur at sun-exposed areas, presenting with dark-brown or light-brown circular hyperpigmentation. A lot of treatment modalities have been used for treatment of freckles like chemicals, electrosurgery and cryotherapy. These treatments may cause undesirable side effects such as scaring (Sarkar et al. in Indian J Dermatol 62(6):578–584, 2017). Microdermabrasion has been used in treatment of freckles; however, the results are not satisfactory, as it removes the outermost layer of the epidermis only (El-Domyati et al. in J Cosmet Dermatol 15(4):503–513, 2016). Also ablative lasers and non-ablative lasers have been used but have not proved to be completely satisfactory and share a common risk of post-inflammatory hyperpigmentation (Jang et al. in Dermatol Surg 26:231–234, 2000). In our study, we have used epiderm-abrasion-assisted intensive pulsed light (IPL) and radiofrequency (RF) to study their effect in treatment of freckles. Patients and methods: this prospective controlled clinical trial was carried out on 48 patients, who presented with extensive facial freckles, in the period between March 2015 and April 2018. The epiderm-abrasion procedure was performed first, and then, electro-photobiomodulation sessions were started two weeks later.
Results
This study was carried out on 48 patients, 39 female and 9 males. Their age ranged between 12 and 58 years old. According to Fitzpatrick classification, four patients were type II, 30 patients were type III, and 14 patients were type IV. The results were excellent in 32 cases, good in 12 cases, fair in four cases, and we have no poor results. Side effects like hyperpigmentation were reported in three patients (6.3%), one case grade III and two cases grade IV Fitzpatrick skin type. No cases with hypopigmentation, or scars, were reported.
Conclusions
Epiderm-abrasion and electro-photobiomodulation (IPL&RF) are effective methods in treatment of facial freckles. Some complications may occur post-procedure such as hyperpigmentation, hypopigmentation and abnormal scarring.
Level of Evidence IV
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References
Tang J, Li Q, Cheng B, Jing L (2014) Primary culture of human face skin melanocytes for the study of hyperpigmentation. Cytotechnology 66(6):891–898
Ezzedine K, Mauger E, Latreille J, Jdid R, Malvy D, Gruber F, Galan P, Hercberg S, Tschachler E, Guinot C (2013) Freckles and solar lentigines have different risk factors in Caucasian women. J Eur Acad Dermatol Venereol 27:e345–356
Sarkar R, Arsiwala S, Dubey N et al (2017) Chemical peels in Melasma: a review with consensus recommendations by Indian Pigmentary Expert Group. Indian J Dermatol 62(6):578–584
Huang YL, Liao YL, Lee SH, Hong HS (2002) Intense pulsed light for the treatment of facial freckles in Asian skin. Dermatol Surg 28:1007–1012
El-Domyati M, Hosam W, Abdel-Azim E, Abdel-Wahab H, Mohamed E (2016) Microdermabrasion: a clinical, histometric, and histopathologic study. J Cosmet Dermatol 15(4):503–513
Chan HH, Fung WK, Ying SY, Kono T (2000) An in vivo trial comparing the use of different types of 532 nm Nd: YAG lasers in the treatment of facial lentigines in oriental patients. Dermatol Surg 26:743–749
Todd MM, Rallis TM, Gerwels JW, Hata TR (2000) A comparison of 3 lasers and liquid nitrogen in the treatment of solar lentigines: a randomized, controlled, comparative trial. Arch Dermatol 136:841–846
Chan JC, Shek SY, Kono T, Yeung CK, Chan HH (2016) A retrospective analysis on the management of pigmented lesions using a picosecond 755-nm alexandrite laser in Asians. Lasers Surg Med 48:23–29
Jang KA, Chung EC, Choi JH et al (2000) Successful removal of freckles in Asian skin with a Q-switched alexandrite laser. Dermatol Surg 26:231–234
Rashid T, Hussain I, Haider M, Haroon TS (2002) Laser therapy of freckles and lentigines with quasi-continuous, frequency-doubled, Nd:YAG (532 nm) laser in Fitzpatrick skin type IV: a 24-month follow-up. J Cosmet Laser Ther 4:81–85
Vachiramon V, Iamsumang W, Triyangkulsri K (2018) Q-switched double frequency Nd:YAG 532-nm nanosecond laser vs. double frequency Nd:YAG 532-nm picosecond laser for the treatment of solar lentigines in Asians. Lasers Med Sci 33(9):1941–1947
Stern RS, Dover JS, Levin JA, Arndt KA (1994) Laser therapy versus cryotherapy of lentigines: a comparative trial. J Am Acad Dermatol 30:985–987
Truchuelo M, Cerdá P, Fernández LF (2017) Chemical peeling: a useful tool in the office. Actas Dermosifiliogr 108(4):315–322
Starkman SJ, Mangat DS (2019) Chemical peels: deep, medium, and light. Facial Plast Surg 35(3):239–247
Nast A, Dréno B, Bettoli V et al (2012) European Dermatology Forum. European evidence-based (S3) guidelines for the treatment of acne. J Eur Acad Dermatol Venereol 26(Suppl 1):1–29
Burm JS, Rhee SC, Kim YW (2007) Superficial dermabrasion and suction blister epidermal grafting for postburn dyspigmentation in Asian skin. Dermatol Surg 33(3):326–332
Anderson RR, Parrish JA (1983) Selective photothermolysis: precise microsurgery by selective absorption of pulsed radiation. Science 220:524–527
Chandrashekar BS, Shenoy C, Madura C (2019) Complications of laser and light-based devices therapy in patients with skin of color. Indian J Dermatol Venereol Leprol 85(1):24–31
Taro K, Samantha Y, Shek H, William F, Kotaro I, Tadashi A (2016) Theoretical review of the treatment of pigmented lesions in Asian skin. Laser Ther 25(3):179–184
Winstanley D, Blalock T, Houghton N, Ross EV (2012) Treatment of benign pigmented lesions using a long-pulse alexandrite laser. J Drugs Dermatol 11(11):1327–1330
Todd MM, Rallis TM, Gerwels JW, Hata TR (2000) A comparison of 3 lasers and liquid nitrogen in the treatment of solar lentigines. A randomized, controlled, comparative trial. Arch Dermatol 136:841–846
Chern PL, Domankevitz Y, Ross EV (2010) Pulsed dye laser treatment of pigmented lesions: a randomized clinical pilot study comparison of 607- and 595-nm wavelength lasers. Lasers Surg Med 42(10):705–709
Willey A, Anderson RR, Azpiazu JL, Bakus AD, Barlow RJ, Dover JS, Garden JM, Kilmer SL (2006) Complications of laser dermatologic surgery. Lasers Surg Med 38(1):1–15
West TB, Alster TS (1999) Effect of pretreatment on the incidence of hyperpigmentation following cutaneous CO2 laser resurfacing. Dermatol Surg 25(1):15–17
Babilas P, Schreml S, Szeimies RM, Landthaler M (2010) Intense pulsed light (IPL): a review. Lasers Surg Med 42(2):93–104
Li N, Han J, Hu D, Cheng J, Wang H, Wang Y, Yang X, Liu J, Li T, Zhao W (2018) Intense pulsed light is effective in treating postburn hyperpigmentation and telangiectasia in Chinese patients. J Cosmet Laser Ther 20(7–8):436–441
Yamashita T, Negishi K et al (2006) Intense pulsed light therapy for superficial pigmented lesions evaluated by reflectance-mode confocal microscopy and optical coherence tomography. J Invest Dermatol 126(10):2281–2286
Huang YL, Liao YL, Lee SH, Hong HS (2002) Intense pulsed light for the treatment of facial freckles in Asian skin. Dermatol Surg 28(11):1007–12 (discussion 1012)
Elmelegy NG, Hegazy AM, Sadaka MS, Abdeldaim DE (2018) Electrophotobiomodulation in the treatment of facial post-burn hypertrophic scars in pediatric patients. Ann Burns Fire Disasters 31(2):127–132
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All the steps performed in this work that involved human participants were in accordance of the institutional, national research committee and with the 1964 Declaration of Helsinki and its later amendments or ethical standards. All principles of ethical and professional conduct have been followed. This article was approved by Tanta University’s Ethical Committee (2015/02/21).
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Elmelegy, N. Epiderm-Abrasion-Assisted Intensive Pulsed Light and Radiofrequency in Aesthetic Treatment Extensive Facial Freckles. Aesth Plast Surg 44, 2259–2267 (2020). https://doi.org/10.1007/s00266-020-01661-x
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DOI: https://doi.org/10.1007/s00266-020-01661-x