Aesthetic Plastic Surgery

, Volume 42, Issue 4, pp 995–1001 | Cite as

Longitudinal Analysis of Superficial Midfacial Fat Volumes Over a 10-Year Period

  • Jacob Tower
  • Kimberly Seifert
  • Boris Paskhover
Original Article Facial Surgery



Volumetric changes to facial fat that occur with aging remain poorly understood. The aim of this study was to evaluate for longitudinal changes to midfacial fat volumes in a group of individuals.


We conducted a retrospective longitudinal study of adult subjects who underwent multiple facial computed tomographic (CT) scans timed at least 8 years apart. Subjects who underwent facial surgery or suffered facial trauma were excluded. Facial CT scans were analyzed, and superficial cheek fat volumes were measured and compared to track changes that occurred with aging.


Fourteen subjects were included in our analysis of facial aging (5 male, 9 female; mean initial age 50.9 years; mean final age 60.4 years). In the right superficial cheek there was an increase in mean (SD) superficial fat volume from 10.33 (2.01) to 10.50 (1.80) cc, which was not statistically significant (P = 0.75). Similar results were observed in the left cheek. There were no statistically significant longitudinal changes to caudal, middle, or cephalad subdivisions of bilateral superficial cheek fat. A simple linear regression was performed to predict superficial cheek fat pad volume based on age which did not reach statistical significance (P = 0.31), with an R2 of 0.039.


This study is the first to quantitatively assess for longitudinal changes to midfacial fat in a group of individuals. Superficial cheek fat remained stable as subjects aged from approximately 50 to 60 years old, with no change in total volume or redistribution within a radiographically defined compartment.

Level of Evidence IV

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Aging Cheek Fat Face Facial rejuvenation Computed tomography 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2018

Authors and Affiliations

  • Jacob Tower
    • 1
  • Kimberly Seifert
    • 2
  • Boris Paskhover
    • 3
  1. 1.Section of Otolaryngology, Department of SurgeryYale School of MedicineNew HavenUSA
  2. 2.Department of Radiology and Biomedical ImagingYale School of MedicineNew HavenUSA
  3. 3.Department of Otolaryngology – Head and Neck SurgeryRutgers New Jersey Medical SchoolNewarkUSA

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