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Correcting Nasojugal Groove with Autologous Cultured Fibroblast Injection: A Pilot Study

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  • Non-Surgical Aesthetic
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Abstract

Background

A new commercial drug that contains autologous cultured fibroblasts has been developed and approved by the United States Food and Drug Administration for improving the appearance of nasolabial folds. However, the treatment requires three sessions every 3–6 weeks. It is known that the skin overlying the nasojugal groove is thinner, and the wrinkle is generally shallower than nasolabial folds. Therefore, we hypothesized that the nasojugal groove could be improved by just one treatment session. Therefore, the purpose of this study was to evaluate the efficacy and safety of autologous cultured fibroblast injection to correct nasojugal grooves.

Methods

Forty-six subjects with nasojugal grooves were enrolled in this study. They were injected with autologous cultured fibroblasts or placebo in one session. Blinded evaluators and subjects assessed the efficacy using a validated wrinkle assessment scale at 4, 12, and 24 weeks after the injection. Information of adverse events was collected at each visit.

Results

Based on the evaluators’ assessment at 24 weeks after the injection, 76% of subjects treated with autologous cultured fibroblasts showed improvement whereas 0% of subjects treated with placebo showed improvement (P < 0.0001). Based on self-assessment at 24 weeks after the injection, 72% of subjects treated with autologous cultured fibroblasts and 45% of subjects treated with placebo showed improvement (P = 0.0662). There were no serious adverse events related to autologous cultured fibroblast injection.

Conclusions

Autologous cultured fibroblast injection might be effective and safe to correct nasojugal grooves.

Level of Evidence I

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Authors and Affiliations

  1. Department of Plastic Surgery, Korea University Guro Hospital, 148 Guro-Dong, Guro-Ku, Seoul, 152-703, South Korea

    Kyung-Chul Moon, Hyun-Su Lee & Seung-Kyu Han

  2. Department of Plastic Surgery, Kyungpook National University School of Medicine, 130 Dongduck-Ro, Jung-Ku, Daegu, South Korea

    Ho-Yun Chung

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  1. Kyung-Chul Moon
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Correspondence to Seung-Kyu Han.

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Moon, KC., Lee, HS., Han, SK. et al. Correcting Nasojugal Groove with Autologous Cultured Fibroblast Injection: A Pilot Study. Aesth Plast Surg 42, 815–824 (2018). https://doi.org/10.1007/s00266-017-1044-3

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