Skip to main content

Advertisement

SpringerLink
Log in

The Effects of Platelet-Rich Plasma on Recovery Time and Aesthetic Outcome in Facial Rejuvenation: Preliminary Retrospective Observations

  • Case Report
  • Experimental/Special Topics
  • Published:
Aesthetic Plastic Surgery Aims and scope Submit manuscript

Abstract

Background

This study focused on the possible effect of platelet-rich plasma (PRP) on recovery time and aesthetic outcome after facial rejuvenation. We conducted a retrospective analysis with regard to recovery time and the aesthetic improvement after treatment among four groups of patients: those treated with fat grafting only (Group I), those treated with fat grafting and PRP (Group II), those treated with a minimal access cranial suspension (MACS)-lift and fat grafting (Group III), and those treated with a MACS-lift, fat grafting, and PRP (Group IV).

Methods

For the first part of this study, i.e., evaluation of recovery time after surgery, the following selection criteria were used: nonsmoking females, aged 35–65 years, with a complete documented follow-up. In total, 82 patients were included in the evaluation of patient-reported recovery time. For the second part of the study, i.e., evaluation of potential differences in aesthetic outcome, the records of these 82 patients were screened for the presence of pre- and postoperative standardized photographs in three views (AP, lateral, and oblique), leaving 37 patients to evaluate. A questionnaire was developed to evaluate the aesthetic outcome in all four groups of patients. This questionnaire was given to an expert panel that consisted of ten plastic surgeons.

Results

The addition of PRP to a lipofilling procedure resulted in a significant drop in the number of days needed to recover before returning to work or to restart social activities [Group I (no PRP) took 18.9 days vs Group II (PRP) took 13.2 days, p = 0.019]. There seemed to be no effect when PRP was added to a MACS-lift + lipofilling procedure. Also, the aesthetic outcome of the lipofilling and MACS-lift + lipofilling groups that received PRP (Groups II and IV) was significantly better than the groups without PRP (Groups I and III).

Conclusions

Adding PRP to facial lipofilling reduces recovery time and improves the overall aesthetic outcome of a MACS-lift.

Level of Evidence V

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Holländer E (1912) Handbuch der kosmetik. Veit & Comp, Leipzig

    Google Scholar 

  2. Willemsen JC, Mulder KM, Stevens HP (2011) Lipofilling with minimal access cranial suspension lifting for enhanced rejuvenation. Aesthet Surg J 31:759–769

    Article  PubMed  Google Scholar 

  3. DeFatta RJ, Williams EF 3rd (2008) Fat transfer in conjunction with facial rejuvenation procedures. Facial Plast Surg Clin North Am 16:383–390 v

    Article  PubMed  Google Scholar 

  4. Kaufman MR, Miller TA, Huang C et al (2007) Autologous fat transfer for facial recontouring: is there science behind the art? Plast Reconstr Surg 119:2287–2296

    Article  PubMed  CAS  Google Scholar 

  5. Pontius AT, Williams EF 3rd (2006) The evolution of midface rejuvenation: combining the midface-lift and fat transfer. Arch Facial Plast Surg 8:300–305

    Article  PubMed  Google Scholar 

  6. Sommer B, Sattler G (2000) Current concepts of fat graft survival: histology of aspirated adipose tissue and review of the literature. Dermatol Surg 26:1159–1166

    Article  PubMed  CAS  Google Scholar 

  7. Guijarro-Martinez R, Miragall Alba L, Marqués Mateo M, Puche Torres M, Pascual Gil JV (2011) Autologous fat transfer to the cranio-maxillofacial region: updates and controversies. J Craniomaxillofac Surg 39(5):359–363

    Article  PubMed  Google Scholar 

  8. Conde-Green A, de Amorim NF, Pitanguy I (2010) Influence of decantation, washing and centrifugation on adipocyte and mesenchymal stem cell content of aspirated adipose tissue: a comparative study. J Plast Reconstr Aesthet Surg 63:1375–1381

    Article  PubMed  Google Scholar 

  9. Conde-Green A, Baptista LS, de Amorin NF et al (2010) Effects of centrifugation on cell composition and viability of aspirated adipose tissue processed for transplantation. Aesthet Surg J 30:249–255

    Article  PubMed  Google Scholar 

  10. Pu LL (2012) Towards more rationalized approach to autologous fat grafting. J Plast Reconstr Aesthet Surg 65:413–419

    Article  PubMed  Google Scholar 

  11. Yamaguchi M, Matsumoto F, Bujo H et al (2005) Revascularization determines volume retention and gene expression by fat grafts in mice. Exp Biol Med (Maywood) 230:742–748

    CAS  Google Scholar 

  12. Nakamura S, Ishihara M, Takikawa M et al (2010) Platelet-rich plasma (PRP) promotes survival of fat-grafts in rats. Ann Plast Surg 65:101–106

    Article  PubMed  CAS  Google Scholar 

  13. Pires Fraga MF, Nishio RT, Ishikawa RS, Perin LF, Helene A Jr, Malheiros CA (2010) Increased survival of free fat grafts with platelet-rich plasma in rabbits. J Plast Reconstr Aesthet Surg 63(12):e818–e822

    Article  PubMed  Google Scholar 

  14. Na JI, Choi JW, Choi HR et al (2011) Rapid healing and reduced erythema after ablative fractional carbon dioxide laser resurfacing combined with the application of autologous platelet-rich plasma. Dermatol Surg 37:463–468

    Article  PubMed  CAS  Google Scholar 

  15. Lee JW, Kim BJ, Kim MN, Mun SK (2011) The efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: a simultaneous split-face trial. Dermatol Surg 37:931–938

    Article  PubMed  CAS  Google Scholar 

  16. Nikolidakis D, Jansen JA (2008) The biology of platelet-rich plasma and its application in oral surgery: literature review. Tissue Eng Part B 14:249–258

    Article  CAS  Google Scholar 

  17. Ono I (2011) A study on the alterations in skin viscoelasticity before and after an intradermal administration of growth factor. J Cutan Aesthet Surg 4:98–104

    Article  PubMed  PubMed Central  Google Scholar 

  18. Redaelli A, Romano D, Marciano A (2010) Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol 9:466–472

    PubMed  Google Scholar 

  19. Alsarraf R, Larrabee WF Jr, Anderson S, Murakami CS, Johnson CM Jr (2001) Measuring cosmetic facial plastic surgery outcomes: a pilot study. Arch Facial Plast Surg 3:198–201

    Article  PubMed  CAS  Google Scholar 

  20. Swanson E (2011) Objective assessment of change in apparent age after facial rejuvenation surgery. J Plast Reconstr Aesthet Surg 64:1124–1131

    Article  PubMed  Google Scholar 

  21. Moolenburgh SE, Mureau MA, Hofer SO (2008) Aesthetic outcome after nasal reconstruction: patient versus panel perception. J Plast Reconstr Aesthet Surg 61:1459–1464

    Article  PubMed  Google Scholar 

  22. Tonnard P, Verpaele A, Monstrey S et al (2002) Minimal access cranial suspension lift: a modified S-lift. Plast Reconstr Surg 109:2074–2086

    Article  PubMed  Google Scholar 

  23. Fitzgerald R, Graivier MH, Kane M et al (2010) Update on facial aging. Aesthet Surg J 30(Suppl):11S–24S

    Article  PubMed  Google Scholar 

  24. Coleman SR (1997) Facial recontouring with lipostructure. Clin Plast Surg 24:347–367

    PubMed  CAS  Google Scholar 

  25. El-Sharkawy H, Kantarci A, Deady J et al (2007) Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties. J Periodontol 78:661–669

    Article  PubMed  CAS  Google Scholar 

  26. Dragoo JL, Braun HJ, Durham JL et al (2012) Comparison of the acute inflammatory response of two commercial platelet-rich plasma systems in healthy rabbit tendons. Am J Sports Med 40(6):1274–1281

    Article  PubMed  Google Scholar 

  27. Nishimura T, Hashimoto H, Nakanishi I, Furukawa M (2000) Microvascular angiogenesis and apoptosis in the survival of free fat grafts. Laryngoscope 110:1333–1338

    Article  PubMed  CAS  Google Scholar 

  28. Thanik VD, Chang CC, Lerman OZ et al (2009) A murine model for studying diffusely injected human fat. Plast Reconstr Surg 124:74–81

    Article  PubMed  CAS  Google Scholar 

  29. Rodriguez-Flores J, Palomar-Gallego MA, Enguita-Valls AB, Rodriguez-Peralto JL, Torres J (2011) Influence of platelet-rich plasma on the histologic characteristics of the autologous fat graft to the upper lip of rabbits. Aesthetic Plast Surg 35(4):480–486

    Article  PubMed  Google Scholar 

  30. Oh DS, Cheon YW, Jeon YR, Lew DH (2011) Activated platelet-rich plasma improves fat graft survival in nude mice: a pilot study. Dermatol Surg 37:619–625

    Article  PubMed  CAS  Google Scholar 

  31. Fukaya Y, Kuroda M, Aoyagi Y et al (2012) Platelet-rich plasma inhibits the apoptosis of highly adipogenic homogeneous preadipocytes in an in vitro culture system. Exp Mol Med 44:330–339

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  32. Kolle SF, Fischer-Nielsen A, Mathiasen AB et al (2013) Enrichment of autologous fat grafts with ex vivo expanded adipose tissue-derived stem cells for graft survival: a randomised placebo-controlled trial. Lancet 382:1113–1120

    Article  PubMed  Google Scholar 

  33. Rophael JA, Craft RO, Palmer JA et al (2007) Angiogenic growth factor synergism in a murine tissue engineering model of angiogenesis and adipogenesis. Am J Pathol 171:2048–2057

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  34. Michalevicz R, Katz F, Stroobant P, Janossy G, Tindle RW, Hoffbrand AV (1986) Platelet-derived growth factor stimulates growth of highly enriched multipotent haemopoietic progenitors. Br J Haematol 63:591–598

    Article  PubMed  CAS  Google Scholar 

  35. Kawahara RS, Deuel TF (1989) Platelet-derived growth factor-inducible gene JE is a member of a family of small inducible genes related to platelet factor 4. J Biol Chem 264:679–682

    PubMed  CAS  Google Scholar 

  36. Patil AS, Sable RB, Kothari RM (2011) An update on transforming growth factor-beta (TGF-beta): sources, types, functions and clinical applicability for cartilage/bone healing. J Cell Physiol 226:3094–3103

    Article  PubMed  CAS  Google Scholar 

  37. Cho JM, Lee YH, Baek RM, Lee SW (2011) Effect of platelet-rich plasma on ultraviolet b-induced skin wrinkles in nude mice. J Plast Reconstr Aesthet Surg 64(2):e31–e39

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors thank Annebeth Kroeskop and Eline Noels for assisting with the online survey.

Conflict of interest

All authors have no potential conflicts of interest with respect to the research, authorship, and publication of this article. None of the authors received financial support for the research, authorship, and publication of this article.

Author information

Authors and Affiliations

  1. Department of Plastic Surgery, University Medical Center Groningen, Groningen, The Netherlands

    Joep C. N. Willemsen & Berend van der Lei

  2. Bergman Clinics The Hague, Binckhortslaan 149, 2516 BA, The Hague, The Netherlands

    Joep C. N. Willemsen, Berend van der Lei & Hieronymus P. J. D. Stevens

  3. Department of Epidemiology, University Medical Center Groningen, Groningen, The Netherlands

    Karin M. Vermeulen

Authors
  1. Joep C. N. Willemsen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Berend van der Lei
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Karin M. Vermeulen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hieronymus P. J. D. Stevens
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Joep C. N. Willemsen.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Willemsen, J.C.N., van der Lei, B., Vermeulen, K.M. et al. The Effects of Platelet-Rich Plasma on Recovery Time and Aesthetic Outcome in Facial Rejuvenation: Preliminary Retrospective Observations. Aesth Plast Surg 38, 1057–1063 (2014). https://doi.org/10.1007/s00266-014-0361-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00266-014-0361-z

Keywords

Search

Navigation