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Effect of Pregabalin and Dexamethasone Addition to Multimodal Analgesia on Postoperative Analgesia Following Rhinoplasty Surgery

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Abstract

Background

We investigated the effect of a combination of pregabalin and dexamethasone, when used as part of a multimodal analgesic regimen, on pain control after rhinoplasty operations.

Methods

Sixty patients were enrolled in this study. They were randomly assigned into three groups: Group C (placebo + placebo), Group P (pregabalin + placebo), and Group PD (pregabalin + dexamethasone). Patients received either pregabalin 300 mg orally 1 h before surgery, dexamethasone 8 mg intravenously during induction, or placebo according to their allocation. Postoperative pain was treated with intravenous patient-controlled analgesia (tramadol, 20-mg bolus dose, 45-min lockout time). The numeric rating scale (NRS), side effects, and consumption of tramadol, pethidine, and ondansetron were assessed.

Results

The median NRS scores at 0, 1, and 6 h after surgery were significantly higher in Group C than in Group PD (p < 0.001 for all). The 24-h consumption of tramadol and pethidine was significantly reduced in Groups P and PD compared to Group C (p < 0.01 and p < 0.01). The total tramadol consumption was decreased by 54.5 % in Group P and 81.9 % in Group PD compared to Group C (p < 0.001 for both). The incidence of nausea was higher in Group C than in Groups P and PD between the postoperative 0–2 and 0–24-h periods (p < 0.05 for both). The frequency of blurred vision was significantly higher in Groups P and PD than in Group C within the 0–24-h period (p < 0.05 for both).

Conclusion

We found that the addition of a single dose of pregabalin and dexamethasone to multimodal analgesia in rhinoplasty surgeries provided efficient analgesia and thus decreased opioid consumption.

Level of Evidence I

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Conflict of interest

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Authors and Affiliations

  1. Department of Anesthesiology and Reanimation, Abant Izzet Baysal University Medical School, Golkoy, 14280, Bolu, Turkey

    Abdullah Demirhan, Umit Yasar Tekelioglu, Akcan Akkaya, Murat Bilgi, Hakan Bayir, Adem Deniz Kurt & Hasan Kocoglu

  2. Department of Otorhinolaryngology, Abant Izzet Baysal University Medical School, Bolu, Turkey

    Tayfun Apuhan

  3. Department of Plastic, Reconstructive and Aesthetic Surgery, FEBOPRAS, Abant Izzet Baysal University Medical School, Bolu, Turkey

    Furkan Erol Karabekmez

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  1. Abdullah Demirhan
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Demirhan, A., Tekelioglu, U.Y., Akkaya, A. et al. Effect of Pregabalin and Dexamethasone Addition to Multimodal Analgesia on Postoperative Analgesia Following Rhinoplasty Surgery. Aesth Plast Surg 37, 1100–1106 (2013). https://doi.org/10.1007/s00266-013-0207-0

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