Skip to main content

Advertisement

Log in

Randomized, Prospective Study of TissuGlu® Surgical Adhesive in the Management of Wound Drainage Following Abdominoplasty

  • Original Article
  • Published:
Aesthetic Plastic Surgery Aims and scope Submit manuscript

Abstract

Background

Wound drainage and seroma formation following abdominoplasty remain significant concerns to both surgeons and patients due to the resulting increased need for patient follow-up and delays in returning to normal function. While a number of approaches are used to reduce wound drainage and seroma formation, there is still no definitive solution. A promising strategy to reduce these complications is the development of an effective method for closing dead space between tissue layers in order to achieve improved patient outcomes.

Methods

We conducted a multicenter, prospective, randomized trial assessing the use of a lysine-derived urethane adhesive (TissuGlu®, Cohera Medical) in patients undergoing abdominoplasty. Twenty patients were randomized to a treatment group and a control group, with the adhesive applied to the abdominal wall prior to closure of the abdominoplasty flap in the treatment group. Control patients underwent an identical procedure but without application of TissuGlu. Outcome measures included time to drain removal, total wound drainage prior to drain removal, and surgical complications.

Results

The use of TissuGlu was associated with a trend toward decreased time to drain removal compared to the control group (2.9 ± 1.4 vs. 3.7 ± 1.5 days; P = 0.13). Mean total drain volume also tended to be lower in the treatment versus the control group (208.7 ± 138.2 vs. 303.5 ± 240.8 ml; P = 0.14). There were no differences in adverse events or complication rates between the two study groups.

Conclusion

The application of TissuGlu in abdominoplasty is safe and may decrease wound drainage and the length of time required for postsurgical drains in abdominoplasty patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Neaman KC, Hansen JE (2007) Analysis of complications from abdominoplasty: a review of 206 cases at a university hospital. Plast Surg 58:292–298

    Article  CAS  Google Scholar 

  2. Hensel JM, Lehman JA, Tantri MP, Parker MG, Wagner DS, Topham NS (2001) An outcomes analysis and satisfaction survey of 199 consecutive abdominoplasties. Ann Plast Surg 46:357–363

    Article  PubMed  CAS  Google Scholar 

  3. Andrades P, Prado A, Danilla S, Guerra C, Benitez S, Sepulveda S, Sciarraffia C, De Carolis V (2007) Progressive tension sutures in the prevention of postabdominoplasty seroma: a prospective, randomized, double-blind clinical trial. Plast Reconstr Surg 120:935–946

    Article  PubMed  CAS  Google Scholar 

  4. Najera RM, Sayeed S, Asheld W, Glickman LT (2010) Comparison of seroma formation following abdominoplasty with or without liposuction. Plast Reconstr Surg 126(Suppl 4):73

    CAS  Google Scholar 

  5. Beer GM, Wallner H (2010) Prevention of seroma after abdominoplasty. Aesthet Surg J 30:414–417

    Article  PubMed  Google Scholar 

  6. Friedman T, O’Brien Coon D, Michaels J, Purnell C, Hur S, Harris DN, Rubin JP (2010) Fleur-de-lis abdominoplasty: a safe alternative to traditional abdominoplasty for the massive weight loss patient. Plast Reconstr Surg 125:1525–1535

    Article  PubMed  CAS  Google Scholar 

  7. Shermak MA, Rotellini-Colvet LA (2008) Seroma development following body contouring surgery for massive weight loss: patient risk factors and treatment strategies. Plast Reconstr Surg 122:280–288

    Article  PubMed  CAS  Google Scholar 

  8. Kim J, Stevenson TR (2006) Abdominoplasty, liposuction of the flanks, and obesity: analyzing risk factors for seroma formation. Plast Reconstr Surg 117:773–779

    Article  PubMed  CAS  Google Scholar 

  9. Zide B (1999) To reduce your seroma rate. Plast Reconstr Surg 103:1098–1099

    PubMed  CAS  Google Scholar 

  10. Stoff A, Reichenberger MA, Richter DF (2007) Comparing the ultrasonically activated scalpel (Harmonic) with high-frequency electrocautery for postoperative serous drainage in massive weight loss surgery. Plast Reconstr Surg 120:1092–1093

    Article  PubMed  CAS  Google Scholar 

  11. Baroudi R, Ferreira CA (1998) Seroma: how to avoid it and how to treat it. Aesthet Surg J 18:439–441

    Article  PubMed  CAS  Google Scholar 

  12. Pollock H, Pollock T (2000) Progressive tension sutures: a technique to reduce local complications in abdominoplasty. Plast Reconstr Surg 105:2583–2586

    Article  PubMed  CAS  Google Scholar 

  13. Weinrach JC, Cronin ED, Smith BK, Collins DR Jr, Cohen BE (2004) Preventing seroma in the latissimus dorsi flap donor site with fibrin sealant. Ann Plast Surg 53:12–16

    Article  PubMed  Google Scholar 

  14. Jones GG, Saour S, Botha AJ, Healy CM (2009) Surgical tip—a novel method of applying fibrin sealant during repair of divarication of the recti via an abdominoplasty incision. J Plast Reconstr Aesthet Surg 62:e457–e458

    Article  PubMed  CAS  Google Scholar 

  15. Gilbert TW, Badylak SF, Gusenoff J, Beckman EJ, Clower DM, Daly P, Rubin JP (2008) Lysine-derived urethane surgical adhesive prevents seroma formation in a canine abdominoplasty model. Plast Reconstr Surg 122:95–102

    Article  PubMed  CAS  Google Scholar 

  16. Antonetti JW, Antonetti AR (2010) Reducing seroma in outpatient abdominoplasty: analysis of 516 consecutive cases. Aesthet Surg J 30:418–425

    Article  PubMed  Google Scholar 

  17. Pollock TA, Pollock H (2010) No-drain abdominoplasty with progressive tension sutures. Clin Plast Surg 37:515–524

    Article  PubMed  Google Scholar 

  18. Khan S, Teotia SS, Mullis WF, Jacobs WE, Beasley ME, Smith KL, Eaves FF 3rd, Finical SJ, Watterson PA (2006) Do progressive tension sutures really decrease complications in abdominoplasty? Ann Plast Surg 56:14–20

    Article  PubMed  CAS  Google Scholar 

  19. Nahas FX, Ferreira LM, Ghelfond C (2007) Does quilting suture prevent seroma in abdominoplasty? Plast Reconstr Surg 119:1060–1064

    Article  PubMed  CAS  Google Scholar 

  20. Ulusoy AN, Polat C, Alvur M, Kandemir B, Bulut F (2003) Effect of fibrin glue on lymphatic drainage and on drain removal time after modified radical mastectomy: a prospective randomized study. Breast J 9:393–396

    Article  PubMed  Google Scholar 

  21. Udén P, Aspegren K, Balldin G, Garne JP, Larsson SA (1993) Fibrin adhesive in radical mastectomy. Eur J Surg 159:263–665

    PubMed  Google Scholar 

  22. Mustonen PK, Härmä MA, Eskelinen MJ (2004) The effect of fibrin sealant combined with fibrinolysis inhibitor on reducing the amount of lymphatic leakage after axillary evacuation in breast cancer. Scand J Surg 93:209–212

    PubMed  CAS  Google Scholar 

  23. Johnson L, Cusick TE, Helmer SD, Osland JS (2005) Influence of fibrin glue on seroma formation after breast surgery. Am J Surg 189:319–323

    Article  PubMed  CAS  Google Scholar 

  24. Dinsmore RC, Harris JA, Gustafson RJ (2000) Effect of fibrin glue on lymphatic drainage after modified radical mastectomy: a prospective randomized trial. Am Surg 66:982–985

    PubMed  CAS  Google Scholar 

  25. Carless PA, Henry DA (2006) Systematic review and meta-analysis of the use of fibrin sealant to prevent seroma formation after breast cancer surgery. Br J Surg 93:810–819

    Article  PubMed  CAS  Google Scholar 

  26. Oliver DW, Hamilton SA, Figle AA, Wood SH, Lamberty BGH (2002) Can fibrin sealant be used to prevent postoperative drainage? A prospective randomized double blind trial. Eur J Plast Surg 24:387–390

    Article  Google Scholar 

  27. Fang RC, Lin SJ, Mustoe TA (2010) Abdominoplasty flap elevation in a more superficial plane: decreasing the need for drains. Plast Reconstr Surg 125:677–682

    Article  PubMed  CAS  Google Scholar 

  28. Momeni A, Heier M, Bannasch H, Stark GB (2009) Complications in abdominoplasty: a risk factor analysis. J Plast Reconstr Aesthet Surg 62:1250–1254

    Article  PubMed  Google Scholar 

Download references

Disclosures

Dr. Klaus J. Walgenbach, Dr. Holger Bannasch, and Dr. Stefan Kalthoff received research funding from Cohera Medical, Inc. to conduct this study. Dr. J. Peter Rubin is a paid advisor to Cohera Medical, Inc.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Klaus J. Walgenbach.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Walgenbach, K.J., Bannasch, H., Kalthoff, S. et al. Randomized, Prospective Study of TissuGlu® Surgical Adhesive in the Management of Wound Drainage Following Abdominoplasty. Aesth Plast Surg 36, 491–496 (2012). https://doi.org/10.1007/s00266-011-9844-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00266-011-9844-3

Keywords

Navigation