Aesthetic Plastic Surgery

, Volume 35, Issue 4, pp 480–486 | Cite as

Influence of Platelet-Rich Plasma on the Histologic Characteristics of the Autologous Fat Graft to the Upper Lip of Rabbits

  • Jordi Rodríguez-FloresEmail author
  • María Angustias Palomar-Gallego
  • Ana Belén Enguita-Valls
  • José Luis Rodríguez-Peralto
  • Jesús Torres
Original Article



This study evaluated the influence of platelet-rich plasma (PRP) on the histologic characteristics of autologous fat grafts to the upper lip of rabbits.


Nine New Zealand white rabbits were used. Eight of the rabbits underwent fat harvest from the groin fat pads using a modified Coleman technique. One side of the upper lip was infiltrated with autologous fat and the other side with fat and PRP. Four of the infiltrated rabbits were killed 8 weeks after the lip augmentation, and the remaining four infiltrated rabbits plus one control case were killed 12 weeks after the procedure. Coronal sections of both upper lips were analyzed microscopically to evaluate the quality of the fat graft, the inflammatory reaction, the presence of oil cysts, the degree of fibrosis, and the neovascularization.


The infiltration of adipose tissue plus PRP presented less inflammatory reaction (p < 0.05) and fewer oil cysts (p < 0.05) than the infiltration of adipose tissue without PRP.


The infiltration of fat tissue plus PRP generates a lower inflammatory reaction and less formation of oil cysts than the infiltration of isolated fat. Platelet-rich plasma increases the maintenance of the transplanted fat cells.


Fat graft Platelet-rich plasma 


Conflict of interest



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Copyright information

© Springer Science+Business Media, LLC and International Society of Aesthetic Plastic Surgery 2010

Authors and Affiliations

  • Jordi Rodríguez-Flores
    • 1
    Email author
  • María Angustias Palomar-Gallego
    • 2
  • Ana Belén Enguita-Valls
    • 3
  • José Luis Rodríguez-Peralto
    • 3
  • Jesús Torres
    • 2
  1. 1.Department of Maxillofacial Surgery12 de Octubre University HospitalMadridSpain
  2. 2.Faculty of Health ScienceUniversity Rey Juan CarlosMadridSpain
  3. 3.Department of Pathology12 de Octubre University HospitalMadridSpain

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