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Nephrotoxicity by dicloxacillin and gentamicin in 163 patients with intertrochanteric hip fractures

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Abstract 

Of 163 patients with intertrochanteric hip fractures 87 received 2 g dicloxacillin and 240 mg of gentamicin preoperatively, and 76 patients had no antibiotic prophylaxis. Preoperative antibiotic prophylaxis was not shown to have any significant effect on wound infections. However, 16 reversible and 1 irreversible cases of kidney toxicity were found among patients receiving antibiotic prophylaxis, whereas there were only four cases of reversible kidney damage among the patients not receiving antibiotics.

Résumé

 Parmi 163 patients avec des fractures intertrochantériennes, 87 patients avaient reçu en préopératoire 2 g Dicloxacilline et 240 mg Gentamicine. 76 patients n’avaient reçu aucune prophylaxie antibiotique. La prophylaxie préopératoire contre les infections n’a montré aucun effet significatif. Cependant dans le groupe avec prophylaxie, 17 affections rénales ont été observées, dont 16 réversibles et 1 irréversible. Parmi les patients n’ayant reçu aucune prophylaxie antibiotique 4 affections rénales réversibles ont été observées.

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Accepted: 29 November 1999

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Solgaard, L., Tuxoe, J., Mafi, M. et al. Nephrotoxicity by dicloxacillin and gentamicin in 163 patients with intertrochanteric hip fractures. International Orthopaedics SICOT 24, 155–157 (2000). https://doi.org/10.1007/s002640000103

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  • DOI: https://doi.org/10.1007/s002640000103

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