Abstract
Purpose
To evaluate the mortality rate, intensive care unit (ICU) referral, and Charlson comorbidity index (CCI) between different types of vaccinated and non-vaccinated patients operated on due to intertrochanteric femoral fracture (IFF) during the pandemic.
Methods
Ninety-six patients (43 males, 53 females) who had proximal femur nails (PFN) for the IFF during the pandemic were included in the study. The patients were divided into four subgroups; non-vaccinated, and different types of vaccinated. Mortality rates, ICU referrals, and CCI relations were evaluated.
Results
No significant difference was observed in terms of demographic data such as age, gender, side, CCI, and ICU referrals between the subgroups (p = 0.164, p = 0.546, p = 0.703, p = 0.771, p = 0.627 respectively). The mortality rate was significantly lower in the Sinovac + BioNTech subgroup (p = 0.044).
Conclusion
No relationship was found between mortality rate, ICU referral, and CCI in different types of vaccinated and non-vaccinated patient subgroups.
Similar content being viewed by others
Data availability
Applicable.
Code availability
Not applicable.
References
Nicola M, Alsafi Z, Sohrabi C et al (2020) The socio-economic implications of the coronavirus pandemic (COVID-19): a review. Int J Surg 78:185–193. https://doi.org/10.1016/j.ijsu.2020.04.018
Kumar Jain V, Lal H, Kumar Patralekh M, Vaishya R (2020) Fracture management during COVID-19 pandemic: a systematic review. J Clin Orthop Trauma 11(Suppl 4):S431–S441. https://doi.org/10.1016/j.jcot.2020.06.035
Bayrak A, Duramaz A, Çakmur BB et al (2021) The effect of COVID-19 positivity on inflammatory parameters and thirty day mortality rates in patients over sixty five years of age with surgically treated intertrochanteric fractures. Int Orthop 45(12):3025–3031. https://doi.org/10.1007/s00264-021-05201-3
Yu MKL, Chan SHS, Cheng S et al (2023) Hesitancy, reactogenicity and immunogenicity of the mRNA and whole-virus inactivated Covid-19 vaccines in pediatric neuromuscular diseases. Hum Vaccin Immunother 19(1):2206278. https://doi.org/10.1080/21645515.2023.2206278
Katoto PD, Tamuzi JL, Brand AS et al (2023) Effectiveness of COVID-19 Pfizer-BioNTech (BNT162b2) mRNA vaccination in adolescents aged 12–17 years: a systematic review and meta-analysis. Hum Vaccin Immunother 19(1):2214495. https://doi.org/10.1080/21645515.2023.2214495
Burahee AS, Barry VE, Sutcliffe RP, Mahroof S (2021) Older patients with proximal femur fractures and SARS-CoV-2 infection - An observational study. SICOT J 7:5. https://doi.org/10.1051/sicotj/2021001
Jang SY, Cha Y, Kim Y, Kim KJ, Kim H, Choy W (2023) Analysis of the effects of COVID-19 on hip fractures in Korea without lockdown: ınterrupted time series analysis using a nationwide cohort. J Korean Med Sci. 38(18):e137. https://doi.org/10.3346/jkms.2023.38.e137
Khabiri SS, Nabian MH, Zeynolabedin H et al (2020) Changes in fracture epidemiology due to COVID-19 crisis; a letter to editor. Arch Acad Emerg Med 8(1):63
Fiolet T, Kherabi Y, MacDonald CJ, Ghosn J, Peiffer-Smadja N (2022) Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review. Clin Microbiol Infect 28(2):202–221. https://doi.org/10.1016/j.cmi.2021.10.005
HadjHassine I (2022) Covid-19 vaccines and variants of concern: a review. Rev Med Virol 32(4):e2313. https://doi.org/10.1002/rmv.2313
Chilamakuri R, Agarwal S (2021) COVID-19: characteristics and therapeutics. Cells 10(2):206. https://doi.org/10.3390/cells10020206
Meo SA, Fahad Al-Jassir F, Al-Qahtani S, Albarrak R, Usmani AM, Klonoff DC (2021) Effect of Pfizer/BioNTech and Oxford/AstraZeneca vaccines against COVID-19 morbidity and mortality in real-world settings at countrywide vaccination campaign in Saudi Arabia. Eur Rev Med Pharmacol Sci. 25(22):7185–7191. https://doi.org/10.26355/eurrev_202111_27271
Polack FP, Thomas SJ, Kitchin N, C4591001 Clinical Trial Group et al (2020) Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 383(27):2603–2615. https://doi.org/10.1056/NEJMoa2034577
Britton A, Jacobs Slifka KM, Edens C et al (2021) Effectiveness of the Pfizer-BioNTech COVID-19 vaccine among residents of two skilled nursing facilities experiencing COVID-19 outbreaks - Connecticut, December 2020-February 2021. MMWR Morb Mortal Wkly Rep. 70(11):396–401. https://doi.org/10.15585/mmwr.mm7011e3
Haas EJ, Angulo FJ, McLaughlin JM et al (2021) Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data. Lancet 397(10287):1819–1829. https://doi.org/10.1016/S0140-6736(21)00947-8
Watson OJ, Barnsley G, Toor J, Hogan AB, Winskill P, Ghani AC (2022) Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. Lancet Infect Dis 22(9):1293–1302. https://doi.org/10.1016/S1473-3099(22)00320-6
Ritchie H, Mathieu E, Rodes-Guirao L, et al (2020) Coronavirus pandemic (COVİD-19). Our World in Data. https://ourworldindata.org/coronavirus
Wouters OJ, Shadlen KC, Salcher-Konrad M et al (2021) Challenges in ensuring global access to COVID-19 vaccines: production, affordability, allocation, and deployment. Lancet 397(10278):1023–1034. https://doi.org/10.1016/S0140-6736(21)00306-8
Machingaidze S, Wiysonge CS (2021) Understanding COVID-19 vaccine hesitancy. Nat Med 27(8):1338–1339. https://doi.org/10.1038/s41591-021-01459-7
Author information
Authors and Affiliations
Contributions
All the authors have approved the final contents of the submission and been actively involved in the planning and in enactment of the study.
Corresponding author
Ethics declarations
Declarations
The study entitled ‘Mortality analyses of elderly patients with proximal femoral fracture during pandemic: vaccination affects or not’ was performed in the Bakırköy Dr. Sadi Konuk Training and Research Hospital, Department of Orthopedics and Traumatology, Istanbul, Turkey. The manuscript submitted does not contain information about medical device(s)/drug(s).
Ethics approval
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Bakırköy Dr. Sadi Konuk Training and Research Hospital Ethics Committee, Ethical Approval (IRB protocol code: 2021/264, application ID: 2022–17-03).
Conflict of ınterest
The authors declare that they have no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Bayrak, A., Tıngır, M., Aslantaş, F.Ç. et al. Mortality analyses of elderly patients with proximal femoral fracture during the pandemic: vaccination affects or not. International Orthopaedics (SICOT) 48, 331–335 (2024). https://doi.org/10.1007/s00264-023-05966-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00264-023-05966-9