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Hip structure analysis and femoral osteodensitometry in aged postmenopausal women with hip osteoarthritis and femoral neck fracture

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Abstract 

Purpose

Osteoarthritis (OA), osteoporosis, and bone fractures are frequent aging-related conditions. Regardless of the growing research interest in the effects of hip OA on femoral fracture risk, data about the region specificity of osteodensitometric and hip structure analysis (HSA) parameters of the proximal femora are lacking in aged postmenopausal women with hip OA compared to individuals with femoral neck fragility fracture.

Methods

This study included 76 postmenopausal women admitted for total hip arthroplasty due to non-traumatic femoral neck fracture (FN_Fx group, n = 39) and hip osteoarthritis (OA group, n = 37).

Results

Osteodensitometric parameters differed significantly between the OA and FN_Fx groups, depicting lower bone mineral density in the FN_Fx group (p < 0.05). The most significant increase in these parameters was registered in the intertrochanteric region of the OA group. Moreover, the OA-induced changes in HSA-derived parameters displayed significant regional heterogeneity, with the intertrochanteric region showing the most notable difference between OA and FN_Fx group.

Conclusion

Our data may indicate that OA displayed the most prominent positive effect on the intertrochanteric femoral region, revealing the regional heterogeneity in structural geometry and biomechanical indices of proximal femora in OA individuals. Since we did not observe significant differences in the femoral neck region, we may speculate that OA does not have a substantial protective effect on the femoral neck fracture risk in aged postmenopausal women.

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Data availability

The data set generated during this study is available from the corresponding author (DD) upon justified request.

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Funding

This article was supported by the Science Fund of the Republic of Serbia (IDEAS program, BoFraM group, project no. 7749444).

Author information

Authors and Affiliations

  1. Center of Bone Biology, Faculty of Medicine, University of Belgrade, Dr Subotica no. 4/II, 11000, Belgrade, Serbia

    Jelena Jadzic, Marija Djuric & Danijela Djonic

  2. University Clinic for Orthopedic Surgery and Traumatology, University Clinical Centre of Serbia, Belgrade, Serbia

    Slavisa Zagorac

Authors
  1. Jelena Jadzic
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  2. Slavisa Zagorac
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  3. Marija Djuric
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  4. Danijela Djonic
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Contributions

All authors read the proposed manuscript and give their substantial contribution to this study. Particular contribution of the authors is listed as follows: ZS and DD designed the study and carried out the patient recruitment. JJ and DD carried out the osteodensitometry and hip structure analysis; JJ, MD, and DD performed statistical analysis; ZS, JJ, and DD interpreted the data; JJ wrote the original draft. ZS, MD, and DD critically reviewed and edited the manuscript. MD took care of project administration/funding; DD provided supervision needed for effective conducting of all study activities. All authors (JJ, ZS, MD, and DD) approved the final version of the manuscript.

Corresponding author

Correspondence to Danijela Djonic.

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Ethics approval

This study was in accordance with the ethical standards of the Ethics Committee of the Faculty of Medicine, University of Belgrade, Serbia, and under the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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All persons gave their informed consent for their inclusion in the study.

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Not applicable.

Competing interests

The authors declare no competing interests.

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Jadzic, J., Zagorac, S., Djuric, M. et al. Hip structure analysis and femoral osteodensitometry in aged postmenopausal women with hip osteoarthritis and femoral neck fracture. International Orthopaedics (SICOT) 46, 2747–2755 (2022). https://doi.org/10.1007/s00264-022-05602-y

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