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Comparison of recycled autograft versus allograft in osteosarcoma with pathological fracture

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Abstract

Purpose

The recycled autograft in biological reconstruction for osteosarcoma has satisfactory outcome. There are few studies about its efficacy in pathological fracture. The aim of the study is to compare the clinical results of recycled autograft to those of allograft in patients with high-grade osteosarcoma with pathological fracture.

Patients and methods

Between October 2010 and March 2018, 30 patients with osteosarcoma combining pathological fracture underwent biological reconstruction. Eleven patients received recycled autograft via extracorporeal irradiation or freezing nitrogen and nineteen patients restored bone defect via allograft to accomplish biological reconstruction.

Results

The mean follow-up was 58.1 months (range 12–120). The mean time to graft-host union of limbs reconstructed using recycled autografts and allografts was 17.45 ± 13.54 and 12.63 ± 12.62 months, respectively, with no significant difference observed between groups (p = 0.176). The five year probability of graft failure therefore did not significantly differ between groups (p = 0.245). The patient five year survival rate was similar (p = 0.229). Post-operative complication rates were similar for the recycled autograft group (54.5%) and the allograft group (57.9%).

Conclusion

The recycled autograft showed comparable clinical results, graft-host union time, complication rate, and graft survival to allograft in biological reconstruction for osteosarcoma with pathological fracture.

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Data availability

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

Code availability

Not applicable.

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Funding

This work was supported by a grant from the Veterans General Hospital-Taipei (V104C-001) and was also financially sponsored by Mrs. Sophie Chang and Dr. Morris Chang.

Author information

Authors and Affiliations

  1. Department of Orthopedics and Joint Reconstruction, Taipei Veterans General Hospital, 201, Sec. 2, Shih-Pai Rd., Taipei, 112, Taiwan, Republic of China

    Pai-Han Wang, Chao-Ming Chen, Cheng-Fong Chen, Wei-Ming Chen & Po-Kuei Wu

  2. Orthopedic Department of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan, Republic of China

    Pai-Han Wang, Chao-Ming Chen, Cheng-Fong Chen, Wei-Ming Chen & Po-Kuei Wu

  3. Therapeutical and Research Center of Musculoskeletal Tumor, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China

    Pai-Han Wang, Chao-Ming Chen, Cheng-Fong Chen, Wei-Ming Chen & Po-Kuei Wu

  4. Institute of Clinical Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan, Republic of China

    Po-Kuei Wu

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  1. Pai-Han Wang
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Contributions

PHW is accountable for the integrity and analysis of the data, and the writing of the manuscript. PHW and PKW are accountable for the collected and analyzed data. CMC and CFC analyzed data and gave experimental support. PKW and WMC planned the study and collected data. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Po-Kuei Wu.

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Ethics approval

The study received ethical approval from the Institutional Review Board of the Taipei Veteran General Hospital, and written informed consent was obtained from all patients before surgical treatment, including that the data may be included in future publications.

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The authors declare no competing interests.

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The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript, and has no conflict of interest. The authors and their immediate family, as well as any research foundation with which they are affiliated, received no financial payments or other benefits from any commercial entity related to this article.

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Cite this article

Wang, PH., Chen, CM., Chen, CF. et al. Comparison of recycled autograft versus allograft in osteosarcoma with pathological fracture. International Orthopaedics (SICOT) 45, 2149–2158 (2021). https://doi.org/10.1007/s00264-021-05121-2

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  • DOI: https://doi.org/10.1007/s00264-021-05121-2

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