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Molecular mechanisms of mechanical load-induced osteoarthritis

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A Correction to this article was published on 24 April 2021

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Abstract

Introduction

Mechanical loading enhances the progression of osteoarthritis. However, its molecular mechanisms have not been established.

Objective

The aim of this review was to summarize the probable mechanisms of mechanical load-induced osteoarthritis.

Methods

A comprehensive search strategy was used to search PubMed and EMBASE databases (from the 15th of January 2015 to the 20th of October 2020). Search terms included “osteoarthritis”, “mechanical load”, and “mechanism”.

Results

Abnormal mechanical loading activates the interleukin-1β, tumour necrosis factor-α, nuclear factor kappa-B, Wnt, transforming growth factor-β, microRNAs pathways, and the oxidative stress pathway. These pathways induce the pathological progression of osteoarthritis. Mechanical stress signal receptors such as integrin, ion channel receptors, hydrogen peroxide-inducible clone-5, Gremlin-1, and transient receptor potential channel 4 are present in the articular cartilages.

Conclusion

This review highlights the molecular mechanisms of mechanical loading in inducing chondrocyte apoptosis and extracellular matrix degradation. These mechanisms provide potential targets for osteoarthritis prevention and treatment.

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Data availability

Not applicable. The materials in this review comes from PubMed and EMBASE and does not involve experimental materials and data.

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Funding

This work was supported by Experimental animal’s platform of Science and Technology Department of Zhejiang Province (Grant No. 2015C37116) and Medical and Health Platform Program of Zhejiang Province (Grant No. 2014RCA028).

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  1. Huzhou Central Hospital, 313000, Huzhou, People’s Republic of China

    Tianshun Fang, Xianhao Zhou, Mingchao Jin, Jiangbo Nie & XIongfeng Li

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No other contributors participate in this manuscript. All the authors have made appropriate contributions to this review. Tianshun Fang designed the study and wrote the manuscript. Xiongfeng Li revised manuscript and approved article submission. Xianhao Zhou, Jiangbo Nie, and Mingchao Jin searched and collected the literature.

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Fang, T., Zhou, X., Jin, M. et al. Molecular mechanisms of mechanical load-induced osteoarthritis. International Orthopaedics (SICOT) 45, 1125–1136 (2021). https://doi.org/10.1007/s00264-021-04938-1

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