Subchondral fracture begins from the bone resorption area in osteonecrosis of the femoral head: a micro-computerised tomography study
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For successful joint preservation in osteonecrosis of the femoral head (ONFH), it is important to understand the mechanism of collapse. The purpose of this study was to investigate the initiation of subchondral fracture in ONFH by using micro-CT imaging of the whole femoral head, focusing on the three-dimensional relationship between the subchondral fracture and the bone resorption area.
A total of 40 femoral heads from 37 patients retrieved during total hip arthroplasty for stage 3A or 3B ONFH by Japanese Investigation Committee criteria were scanned using micro-CT with a 0.146-mm thickness cuts. We divided the cohort into early and late collapsed stages according to a threshold of 3 mm of collapse as measured by micro-CT.
According to the analysis on multiple radial plane views in the whole femoral head, there were two interesting findings. First, the initial fracture cracks ran between separated bone resorption areas at the anterosuperior portions of all 18 femoral heads in the early collapsed stage. Second, fractures of the necrotic bone at the sclerotic boundary and a fibrous, granulation-like, low-density tissue along the necrotic side of the sclerotic boundary were seen in 19 of the 22 in the late collapsed stage. After bone resorption around the retinaculum and teres insertion initiates the subchondral fracture, bone resorption expanding at the anterosuperior portion of the femoral head may result in the spread of fracture and the potential for massive collapse.
Three-dimensional micro-CT showed bone resorption around the reparative zone initiates the subchondral fracture in ONFH.
KeywordsOsteonecrosis of the femoral head Micro-CT Subchondral fracture Bone resorption Collapse
We thank Dr. Nobuo Nakamura for the scientific advice and many insightful discussions.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 1.Bullough PG, DiCarlo EF. (1990) Subchondral avascular necrosis: a common cause of arthritis. Ann Rheum Dis 49(6):412–420. ReviewGoogle Scholar
- 4.Glimcher MJ, Kenzora JE (1979) The biology of osteonecrosis of the human femoral head and its clinical implications: II. The pathological changes in the femoral head as an organ and in the hip joint. Clin Orthop Relat Res (139):283–312Google Scholar
- 6.Karasuyama K, Yamamoto T, Motomura G, Sonoda K, Kubo Y, Iwamoto Y (2015) The role of sclerotic changes in the starting mechanisms of collapse: a histomorphometric and FEM study on the femoral head of osteonecrosis. Bone 81:644–648. https://doi.org/10.1016/j.bone.2015.09.009 CrossRefPubMedGoogle Scholar
- 9.Wang C, Wang X, Xu XL, Yuan XL, Gou WL, Wang AY, Guo QY, Peng J, Lu SB (2014) Bone microstructure and regional distribution of osteoblast and osteoclast activity in the osteonecrotic femoral head. PLoS One 9(5):e96361. https://doi.org/10.1371/journal.pone.0096361 eCollection 2014CrossRefPubMedPubMedCentralGoogle Scholar