Differential expression of adipokines in knee osteoarthritis patients with and without metabolic syndrome
- 186 Downloads
The purpose of this study was to compare adipokines levels in plasma and synovial fluid (SF) between knee osteoarthritis (OA) patients with and without metabolic syndrome (MetS), and to evaluate the associations between adipokines levels and clinical severity of knee osteoarthritis.
Eighty female patients with knee osteoarthritis were enrolled in the study. These patients were divided into two groups: patients with and without MetS. Clinical severity was evaluated according to visual analogue scale (VAS) pain scores and Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores. Adipokines and soluble leptin receptor levels in plasma and SF were determined by a sandwich enzyme-linked immunosorbent assay.
Forty-three (54%) osteoarthritis patients with MetS and 37 (46%) osteoarthritis patients without MetS were enrolled as MetS-OA group and nMetS-OA group, respectively. VAS pain and WOMAC scores were higher in MetS-OA group compared with those in nMets-OA group (p < 0.01). The leptin and free leptin levels in plasma and SF were significantly higher in MetS-OA group than those in nMetS-OA group, while the adiponectin levels were lower (All p < 0.01). Significant differences existed even after adjustment for body mass index (BMI) (p < 0.05). There were no significant associations between adipokines levels and the clinical severity of OA in MetS-OA group and nMetS-OA group respectively (p > 0.05).
Leptin was higher and adiponectin was lower in knee osteoarthritis patients with MetS compared to those without MetS, independent of BMI. The higher SF and plasma levels of leptin in MetS-OA patients may need further studies to delineate their pathophysiological relationships.
KeywordsOsteoarthritis Metabolic syndrome Adipokines Clinical severity Knee
The authors gratefully acknowledge financial support of this study by the Natural Science Funding of Jilin province (20160101056JC).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 5.Tomi AL, Sellam J, Lacombe K, Fellahi S, Sebire M, Rey-Jouvin C, Miquel A, Bastard JP, Maheu E, Haugen IK, Felson DT, Capeau J, Girard PM, Berenbaum F, Meynard JL (2016) Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study. Ann Rheum Dis 75(12):2101–2107. https://doi.org/10.1136/annrheumdis-2016-209262 CrossRefPubMedPubMedCentralGoogle Scholar
- 8.Abella V, Scotece M, Conde J, Lopez V, Lazzaro V, Pino J, Gomez-Reino JJ, Gualillo O (2014) Adipokines, metabolic syndrome and rheumatic diseases. J Immunol Res. https://doi.org/10.1155/2014/343746
- 10.Stenholm S, Koster A, Alley DE, Visser M, Maggio M, Harris TB, Egan JM, Bandinelli S, Guralnik JM, Ferrucci L (2010) Adipocytokines and the metabolic syndrome among older persons with and without obesity: the InCHIANTI study. Clin Endocrinol 73(1):55–65. https://doi.org/10.1111/j.1365-2265.2009.03742.x CrossRefGoogle Scholar
- 11.Chedraui P, Perez-Lopez FR, Escobar GS, Palla G, Montt-Guevara M, Cecchi E, Genazzani AR, Simoncini T (2014) Circulating leptin, resistin, adiponectin, visfatin, adipsin and ghrelin levels and insulin resistance in postmenopausal women with and without the metabolic syndrome. Maturitas 79(1):86–90. https://doi.org/10.1016/j.maturitas.2014.06.008 CrossRefPubMedGoogle Scholar
- 16.Karvonen-Gutierrez CA, Harlow SD, Jacobson J, Mancuso P, Jiang Y (2014) The relationship between longitudinal serum leptin measures and measures of magnetic resonance imaging-assessed knee joint damage in a population of mid-life women. Ann Rheum Dis 73(5):883–889. https://doi.org/10.1136/annrheumdis-2012-202685 CrossRefPubMedGoogle Scholar
- 18.Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F, American Heart A, National Heart L, Blood I (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Circulation 112(17):2735–2752. https://doi.org/10.1161/CIRCULATIONAHA.105.169404 CrossRefPubMedGoogle Scholar
- 19.Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15(12):1833–1840PubMedGoogle Scholar
- 21.Calvet J, Orellana C, Gratacos J, Berenguer-Llergo A, Caixas A, Chillaron JJ, Pedro-Botet J, Garcia-Manrique M, Navarro N, Larrosa M (2016) Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis: a cross-sectional study in female patients with joint effusion. Arthritis Res Ther 18(1):207. https://doi.org/10.1186/s13075-016-1103-1 CrossRefPubMedPubMedCentralGoogle Scholar