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Viscosupplementation in patients with severe osteoarthritis of the knee: six month follow-up of a randomized, double-blind clinical trial

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Abstract

Purpose

To analyze the early outcomes of viscosupplementation in patients with severe knee osteoarthritis.

Method

A randomized, double-blind clinical trial of 143 knees divided into three groups: Group 1 – intra-articular injection of triamcinolone; Group 2 – hylan GF20; and Group 3 – triamcinolone + hylan GF20. Outcomes were evaluated using Lysholm and KSS scores before treatment and after one, three and six months.

Results

Within-group comparisons revealed improvements in Lysholm scores in all groups in the one month evaluation relative to pre-treatment levels (p < 0.01). This improvement was maintained in the third month after treatment (p > 0.05). Scores at six months were significantly lower than those observed in the previous follow-up assessments (p < 0.05), but still higher than pre-treatment levels (p < 0.05). KSS scores also improved after one month relative to pre-treatment levels (p < 0.01). This improvement was still present at three and six months after treatment in the corticosteroid group (p > 0.05). Patients treated with hylan GF20 showed lower scores in the last evaluation relative to month one (p < 0.05). No significant differences were observed between the treatment groups (p > 0.05).

Conclusions

Viscosupplementation increased functional scores in patients with severe osteoarthritis of the knee, especially within three months of injection. However, it was not superior to the use of triamcinolone.

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Authors and Affiliations

  1. Orthopedics Department, Hospital Federal dos Servidores do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

    André Luiz Siqueira Campos, Edmilson Barbosa da Silva, Sami Gobbi Fayad, Lucas Delunardo Acerbi, Felipe Nunes de Almeida & Nelson Hiroyuki Myiabe Ooka

  2. Rua Comendador Queiroz, 68/501, Icaraí, Niterói, RJ, 24230-220, Brazil

    André Luiz Siqueira Campos

  3. Department of General and Specialized Surgery, Universidade Federal Fluminense (UFF), Niterói, RJ, Brazil

    Rodrigo Satamini Pires e Albuquerque & Vinícius Schott Gameiro

  4. Orthopedics Department, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil

    José Sergio Franco

Authors
  1. André Luiz Siqueira Campos
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  2. Rodrigo Satamini Pires e Albuquerque
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  3. Edmilson Barbosa da Silva
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  6. Felipe Nunes de Almeida
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  7. Nelson Hiroyuki Myiabe Ooka
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  8. José Sergio Franco
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  9. Vinícius Schott Gameiro
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Corresponding author

Correspondence to André Luiz Siqueira Campos.

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The authors have no financial relationships relevant to this article to disclose.

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Campos, A.L.S., e Albuquerque, R.S.P., da Silva, E.B. et al. Viscosupplementation in patients with severe osteoarthritis of the knee: six month follow-up of a randomized, double-blind clinical trial. International Orthopaedics (SICOT) 41, 2273–2280 (2017). https://doi.org/10.1007/s00264-017-3625-9

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  • DOI: https://doi.org/10.1007/s00264-017-3625-9

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