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The effect of simvastatin on periprosthetic bone mineral density in the hypercholesterolaemic patients after total hip arthroplasty

International Orthopaedics volume 42, pages 59–64 (2018)Cite this article

Abstract

Objective

The purpose of this study was to investigate the effect of simvastatin on periprosthetic bone mineral density (BMD) in hypercholesterolaemic patients after total hip arthroplasty.

Methods

From January 2012 to December 2015, a total of 42 consecutive hypercholesterolaemic patients with total hip arthroplasty were recruited for this study. The simvastatin group was 21 patients (15 males, 6 females) with average age of 69.4 ± 6.6 years treated with simvastatin for one year post-operatively, and the control group was the other 21 patients (12 males, 9 females) who did not take simvastatin. These parameters of the periprosthetic bone mineral density after total hip arthroplasty were collected by dual energy X-ray absorptiometry(DEXA) one week and three, six, 12 months post-operatively.

Results

In the control group patients showed significant loss of periprosthetic BMD in ROIs 1, 2, 6, and 7 throughout the study period. The loss of BMD in ROIs 3 and 5 was only significantly observed at three months follow-up and recovered thereafter. There were no significant detected changes of BMD in ROI 4. In the Simvastatin group, the percentage of BMD loss was significantly less (P < 0.05) in ROI 1, 2, 6 and 7 throughout the study period than the control group. The percentage of BMD loss were significant observed in ROI 3 and 5 at three months follow-up, which were also significantly less (P < 0.05) than in the control group. A slight gain of BMD was measured in ROI 4 at 12 months follow-up (1.419%, P < 0.05).

Conclusion

Simvastatin administered for one year post-operatively can effectively prevent periprosthetic bone loss after total hip arthroplasty.

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Affiliations

  1. Department of Orthopedics, Jintan Hospital Affiliated to Jiangsu University, No. 16 South Gate Street, Jintan, Jiangsu, China

    Xing Zhang, Yawen Sun, Hua Xie, Jun Liu, Yinbi Zhao & Zhonghua Xu

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  1. Xing Zhang
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  2. Yawen Sun
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  3. Hua Xie
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  4. Jun Liu
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  6. Zhonghua Xu
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Correspondence to Zhonghua Xu.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Informed consent was obtained from all individual participants included in the study.

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Zhang, X., Sun, Y., Xie, H. et al. The effect of simvastatin on periprosthetic bone mineral density in the hypercholesterolaemic patients after total hip arthroplasty. International Orthopaedics (SICOT) 42, 59–64 (2018). https://doi.org/10.1007/s00264-017-3551-x

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  • DOI: https://doi.org/10.1007/s00264-017-3551-x

Keywords

  • Simvastatin
  • Total hip arthroplasty (THA)
  • Bone mineral density (BMD)