International Orthopaedics

, Volume 38, Issue 9, pp 1877–1884 | Cite as

Nanobiotechnology and bone regeneration: a mini-review

  • Nadomir Gusić
  • Alan IvkovićEmail author
  • John VaFaye
  • Andreja Vukasović
  • Jana Ivković
  • Damir Hudetz
  • Saša Janković
Review Article


The purpose of this paper is to review current developments in bone tissue engineering, with special focus on the promising role of nanobiotechnology. This unique fusion between nanotechnology and biotechnology offers unprecedented possibilities in studying and modulating biological processes on a molecular and atomic scale. First we discuss the multiscale hierarchical structure of bone and its implication on the design of new scaffolds and delivery systems. Then we briefly present different types of nanostructured scaffolds, and finally we conclude with nanoparticle delivery systems and their potential use in promoting bone regeneration. This review is not meant to be exhaustive and comprehensive, but aims to highlight concepts and key advances in the field of nanobiotechnology and bone regeneration.


Bone Nanotechnology Scaffold Drug delivery Cell seeding 



This project has received funding from the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement No.278807.


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Copyright information

© SICOT aisbl 2014

Authors and Affiliations

  • Nadomir Gusić
    • 1
  • Alan Ivković
    • 2
    • 3
    • 4
    Email author
  • John VaFaye
    • 5
  • Andreja Vukasović
    • 6
  • Jana Ivković
    • 2
  • Damir Hudetz
    • 3
    • 4
  • Saša Janković
    • 3
  1. 1.Department of TraumatologyGeneral Hospital PulaPulaCroatia
  2. 2.Department of BiotechnologyUniversity of RijekaRijekaCroatia
  3. 3.Department of Orthopaedic SurgeryUniversity Hospital Sveti DuhZagrebCroatia
  4. 4.Department of Orthopaedic SurgerySt. Catherine’s HospitalZabokCroatia
  5. 5.Department of Orthopaedic Surgery, Care UK Northeast London NHS Treatment CentreKing George HospitalIlfordUK
  6. 6.Department of Histology and Embryology, School of MedicineUniversity of ZagrebZagrebCroatia

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