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International Orthopaedics

, Volume 38, Issue 6, pp 1321–1328 | Cite as

The effect of platelet-rich plasma on osteochondral defects treated with mosaicplasty

  • Egemen AltanEmail author
  • Kerem Aydin
  • Omer Erkocak
  • Hakan Senaran
  • Serdar Ugras
Original Paper

Abstract

Purpose

This study investigated the efficacy of platelet-rich plasma (PRP) on articular surfaces on which the mosaicplasty technique was performed. Our hypothesis was that PRP can accelerate the osseointegration process and enhance the quality of articular integrity after the mosaicplasty procedure.

Methods

Standard defects were created in the femoral groove of both patellofemoral joints of 12 New Zealand rabbits. PRP solution was placed inside the defect before fixation of the osteochondral autografts and injected inside the involved joint after capsular closure of the tested knees. The contralateral knees served as the control sides. The animals were euthanized three or six weeks after mosaicplasty, and both limbs were assessed according to Pineda’s histological grading scale. Significance level was set at p ≤ 0.05 a priori, and the Mann–Whitney U test was used for statistical analysis.

Results

Histologic findings at the interface between the transferred autograft and the original cartilage revealed better integration of the adjacent surfaces in the mosaicplasty with PRP group three weeks after the procedure; the difference was significant (p < 0.05). However, no significant difference in the transition zone was observed between the groups six weeks after the experiment (p = 0.59).

Conclusions

Our animal model showed that adjunctive use of PRP produced a better healing response and resulted in superior histological scores after three weeks compared with the mosaicplasty-only procedure. Interpretation of our results is important in terms of rapid return to previous activity levels. Thus, application of PRP can represent a valid therapeutic option for improving the efficacy of mosaicplasty by stimulating the local healing response.

Keywords

Platelet-rich plasma Osteochondral defect Mosaicplasty Cartilage 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Egemen Altan
    • 1
    Email author
  • Kerem Aydin
    • 1
  • Omer Erkocak
    • 1
  • Hakan Senaran
    • 1
  • Serdar Ugras
    • 1
  1. 1.Department of Orthopaedics and TraumatologySelcuk UniversityKonyaTurkey

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