Abstract
Purpose
The most common long-term complication of joint arthroplasty is aseptic loosening. The proinflammatory cytokines secreted by macrophages are involved in aseptic loosening. Recently, a novel proinflammatory cytokine IL-17C was reported to participate in inflammatory diseases by synergising with proinflammatory cytokines. However, the relationship between IL-17C and the aseptic loosening is unclear.
Methods
The tissues around aseptic loosened implants were collected during revision surgery and handled by formalin fixation and embedded in paraffin. The presence of IL-17C in the tissues around the aseptic loosened implants was investigated in 12 aseptic loosening patients using immunofluorescence.
Results
The presence of IL-17C protein in the tissues around aseptic loosened implants was detected by immunofluorescence. There are no statistical differences between optical density of IL-17C in aseptic loosening samples and in rheumatoid arthritis samples (positive control).
Conclusions
These results suggest the presence of IL-17C in aseptic loosening. Interleukin-17C was related to the inflammation of aseptic loosening, possibly by contributing to the inflammation and osteolysis in the tissues surrounding aseptic loosened implants.
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Acknowledgments
This work was funded by the National Natural Science Foundation of China (81171710) (http://www.nsfc.gov.cn/Portal0/default166.htm), the Industrialisation of New and High Technology Projects–Industrial Research of Guangdong Province, China (2011B010500012), and the International Science and Technology Cooperation of Science and Technology of Guangdong Province, China (2010B050300009) (http://www.gdstc.gov.cn/eng/mission.html). The sponsors had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. We sincerely thank Mr. Chaohong Li (Zhongshan Medical school of Sun Yat-sen University, Guangzhou, China) for his technical guidance and device support.
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Hou, C., Zhang, Y., Yu, S. et al. Presence of interleukin-17C in the tissue around aseptic loosened implants. International Orthopaedics (SICOT) 37, 953–959 (2013). https://doi.org/10.1007/s00264-013-1812-x
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DOI: https://doi.org/10.1007/s00264-013-1812-x