Abstract
Purpose
The purpose of this study was to evaluate the effects of epineurotomy on the post-surgical median nerve volume and clinical outcomes in carpal tunnel syndrome (CTS) patients with a prominent nerve narrowing.
Methods
This was a prospective, randomised, double-blind controlled trial. Patients (n = 50) were randomised (1:1) to open-field surgical carpal tunnel release followed by a longitudinal epineurotomy of the nerve (test), or to open-field release without epineurotomy (control).
Results
The nerve volume was slightly larger in the test group 90 days post-surgery (by 10.5 %, p = 0.157) but not 180 days post-surgery. No relevant electropyhsiological or clinical difference between groups and no effect of the nerve volume was observed. The subjective pain reduction was slightly more prominent in the control group at 180 days. Larger post-surgical nerve volume was associated with lower pain, but only in the control group.
Conclusions
Even in selected CTS patients, longitudinal epineurotomy confers no benefit regarding the nerve volume or clinical outcomes over a simple carpal tunnel release.
This is a preview of subscription content, access via your institution.





References
Bilić R, Kolundzić R, Jelić M (2001) Overuse syndromes of the hand, forearm and the elbow. Arh Hig Rada Toksikol 52:403–414
Kanaan N, Sawaya RA (2001) Carpal tunnel syndrome: modern diagnostic and management techniques. Br J Gen Pract 51:311–314
Lowry WEJ, Follender AB (1988) Interfascicular neurolysis in the severe carpal tunnel syndrome. A prospective, randomized, double-blind, controlled study. Clin Orthop 227:251–254
Bande S, DeSmet L, Fabry G (1994) The results of carpal tunnel release: open versus endoscopic technique. J Hand Surg 19:14–17
Foulkes GD, Atkinson RE, Beuchel C, Doyle JR, Singer DI (1994) Outcome following epineurotomy in carpal tunnel syndrome: a prospective, randomized clinical trial. J Hand Surg 19:539–547
Leinberry CF, Hammond NL III, Siegfried JW (1997) The role of epineurotomy in the operative treatment of carpal tunnel syndrome. J Bone Joint Surg 79:555–557
Palazzi S, Palazzi JL (1980) Neurolysis in compressive neuropathies. Int Surg 65:509–514
Fissete J, Onkelinx A (1979) Treatment of carpal tunnel syndrome. Comparative study with and without epineurolysis. Hand 11:206–210
Duncan KH, Lewis RC Jr, Foreman KA, Nordyke MD (1987) Treatment of carpal tunnel syndrome by members of the American Society for Surgery of the Hand: results of a questionnaire. J Hand Surg 12:384–391
Blair WF, Goetz DD, Ross MA, Steyers CM, Chang P (1996) Carpal tunnel release with and without epineurotomy: a comparative prospective trial. J Hand Surg 21:655–661
Gelberman RH, Pfeffer GB, Galbraith RT, Szabo RM, Rydevik B, Dimick M (1987) Results of treatment of severe carpal-tunnel syndrome without internal neurolysis of the median nerve. J Bone Joint Surg 69:896–903
Rhoades CE, Mowery CA, Gelberman RH (1985) Results of internal neurolysis of the median nerve for severe carpal-tunnel syndrome. J Bone Joint Surg 67:253–256
Bower JA, Stanisz GJ, Keir PJ (2006) An MRI evaluation of carpal tunnel dimensions in healthy wrists: implications for carpal tunnel syndrome. Clin Biomech 21:816–825
Monagle K, Dai G, Chu A, Burnham RS, Snyder RE (1999) Quantitative MR imaging of carpal tunnel syndrome. Am J Roentgenol 172:1581–1586
Jablecki CK, Andary MT, So YT, Wilkins DE, Williams FH (1993) Literature review of the usefulness of nerve conduction studies and electromyography for the evaluation of patients with carpal tunnel syndrome. Muscle Nerve 16:1392–1414
Bilić R, Kolundžić R, Trkulja V, Crnković T, Vuković A (2006) The carpal tunnel syndrome: medical and economic advantages of well-timed surgical treatment. Lijec Vjesn 128:143–149
Liu H, Wu T (2005) Sample size calculation and power analysis of time-averaged difference. J Modern Applied Stat Methods 4:434–445
Corradi M, Paganelli E, Pavesi G (1989) Internal neurolysis and flexor tenosynovectomy: adjuncts in the treatment of chronic median nerve compression at the wrist in hemodialysis patients. Microsurgery 10:248–250
Holmgren LH, Leszniewski W, Linden U, Rabow L, Thorling J (1985) Internal neurolysis or ligament division only in carpal tunnel syndrome-results of a randomized study. Acta Neurochir 74:118–121
Holmgren LH, Rabow L (1987) Internal neurolysis or ligament division only in carpal tunnel syndrome. II. A 3 year follow-up with an evaluation of various neurophysiological parameters for diagnosis. Acta Neurochir 87:44–47
Chen CH, Wu T, Sun JS, Lin WH, Chen CY (2012) Unusual causes of carpal tunnel syndrome: space occupying lesions. J Hand Surg 37:14–19
Pećina MM, Krmpotić-Nemanić J, Markiewitz AD (2001) Tunnel syndromes. Peripheral nerve compression syndromes, 3rd edn. CRC Press, Boca Raton, pp 125–139
Conflict of interest
The authors declare that they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Crnković, T., Bilić, R., Trkulja, V. et al. The effect of epineurotomy on the median nerve volume after the carpal tunnel release: a prospective randomised double-blind controlled trial. International Orthopaedics (SICOT) 36, 1885–1892 (2012). https://doi.org/10.1007/s00264-012-1565-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00264-012-1565-y
Keywords
- Grip Strength
- Median Nerve
- Carpal Tunnel Syndrome
- Carpal Tunnel
- Carpal Tunnel Release