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The effect of epineurotomy on the median nerve volume after the carpal tunnel release: a prospective randomised double-blind controlled trial

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Abstract

Purpose

The purpose of this study was to evaluate the effects of epineurotomy on the post-surgical median nerve volume and clinical outcomes in carpal tunnel syndrome (CTS) patients with a prominent nerve narrowing.

Methods

This was a prospective, randomised, double-blind controlled trial. Patients (n = 50) were randomised (1:1) to open-field surgical carpal tunnel release followed by a longitudinal epineurotomy of the nerve (test), or to open-field release without epineurotomy (control).

Results

The nerve volume was slightly larger in the test group 90 days post-surgery (by 10.5 %, p = 0.157) but not 180 days post-surgery. No relevant electropyhsiological or clinical difference between groups and no effect of the nerve volume was observed. The subjective pain reduction was slightly more prominent in the control group at 180 days. Larger post-surgical nerve volume was associated with lower pain, but only in the control group.

Conclusions

Even in selected CTS patients, longitudinal epineurotomy confers no benefit regarding the nerve volume or clinical outcomes over a simple carpal tunnel release.

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References

  1. Bilić R, Kolundzić R, Jelić M (2001) Overuse syndromes of the hand, forearm and the elbow. Arh Hig Rada Toksikol 52:403–414

    PubMed  Google Scholar 

  2. Kanaan N, Sawaya RA (2001) Carpal tunnel syndrome: modern diagnostic and management techniques. Br J Gen Pract 51:311–314

    PubMed  CAS  Google Scholar 

  3. Lowry WEJ, Follender AB (1988) Interfascicular neurolysis in the severe carpal tunnel syndrome. A prospective, randomized, double-blind, controlled study. Clin Orthop 227:251–254

    PubMed  Google Scholar 

  4. Bande S, DeSmet L, Fabry G (1994) The results of carpal tunnel release: open versus endoscopic technique. J Hand Surg 19:14–17

    CAS  Google Scholar 

  5. Foulkes GD, Atkinson RE, Beuchel C, Doyle JR, Singer DI (1994) Outcome following epineurotomy in carpal tunnel syndrome: a prospective, randomized clinical trial. J Hand Surg 19:539–547

    Article  CAS  Google Scholar 

  6. Leinberry CF, Hammond NL III, Siegfried JW (1997) The role of epineurotomy in the operative treatment of carpal tunnel syndrome. J Bone Joint Surg 79:555–557

    PubMed  CAS  Google Scholar 

  7. Palazzi S, Palazzi JL (1980) Neurolysis in compressive neuropathies. Int Surg 65:509–514

    PubMed  CAS  Google Scholar 

  8. Fissete J, Onkelinx A (1979) Treatment of carpal tunnel syndrome. Comparative study with and without epineurolysis. Hand 11:206–210

    Article  Google Scholar 

  9. Duncan KH, Lewis RC Jr, Foreman KA, Nordyke MD (1987) Treatment of carpal tunnel syndrome by members of the American Society for Surgery of the Hand: results of a questionnaire. J Hand Surg 12:384–391

    CAS  Google Scholar 

  10. Blair WF, Goetz DD, Ross MA, Steyers CM, Chang P (1996) Carpal tunnel release with and without epineurotomy: a comparative prospective trial. J Hand Surg 21:655–661

    Article  CAS  Google Scholar 

  11. Gelberman RH, Pfeffer GB, Galbraith RT, Szabo RM, Rydevik B, Dimick M (1987) Results of treatment of severe carpal-tunnel syndrome without internal neurolysis of the median nerve. J Bone Joint Surg 69:896–903

    PubMed  CAS  Google Scholar 

  12. Rhoades CE, Mowery CA, Gelberman RH (1985) Results of internal neurolysis of the median nerve for severe carpal-tunnel syndrome. J Bone Joint Surg 67:253–256

    PubMed  CAS  Google Scholar 

  13. Bower JA, Stanisz GJ, Keir PJ (2006) An MRI evaluation of carpal tunnel dimensions in healthy wrists: implications for carpal tunnel syndrome. Clin Biomech 21:816–825

    Article  Google Scholar 

  14. Monagle K, Dai G, Chu A, Burnham RS, Snyder RE (1999) Quantitative MR imaging of carpal tunnel syndrome. Am J Roentgenol 172:1581–1586

    CAS  Google Scholar 

  15. Jablecki CK, Andary MT, So YT, Wilkins DE, Williams FH (1993) Literature review of the usefulness of nerve conduction studies and electromyography for the evaluation of patients with carpal tunnel syndrome. Muscle Nerve 16:1392–1414

    Article  PubMed  CAS  Google Scholar 

  16. Bilić R, Kolundžić R, Trkulja V, Crnković T, Vuković A (2006) The carpal tunnel syndrome: medical and economic advantages of well-timed surgical treatment. Lijec Vjesn 128:143–149

    PubMed  Google Scholar 

  17. Liu H, Wu T (2005) Sample size calculation and power analysis of time-averaged difference. J Modern Applied Stat Methods 4:434–445

    Google Scholar 

  18. Corradi M, Paganelli E, Pavesi G (1989) Internal neurolysis and flexor tenosynovectomy: adjuncts in the treatment of chronic median nerve compression at the wrist in hemodialysis patients. Microsurgery 10:248–250

    Article  PubMed  CAS  Google Scholar 

  19. Holmgren LH, Leszniewski W, Linden U, Rabow L, Thorling J (1985) Internal neurolysis or ligament division only in carpal tunnel syndrome-results of a randomized study. Acta Neurochir 74:118–121

    Article  Google Scholar 

  20. Holmgren LH, Rabow L (1987) Internal neurolysis or ligament division only in carpal tunnel syndrome. II. A 3 year follow-up with an evaluation of various neurophysiological parameters for diagnosis. Acta Neurochir 87:44–47

    Article  CAS  Google Scholar 

  21. Chen CH, Wu T, Sun JS, Lin WH, Chen CY (2012) Unusual causes of carpal tunnel syndrome: space occupying lesions. J Hand Surg 37:14–19

    Article  Google Scholar 

  22. Pećina MM, Krmpotić-Nemanić J, Markiewitz AD (2001) Tunnel syndromes. Peripheral nerve compression syndromes, 3rd edn. CRC Press, Boca Raton, pp 125–139

    Google Scholar 

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The authors declare that they have no conflict of interest.

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Correspondence to Tomislav Crnković.

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Crnković, T., Bilić, R., Trkulja, V. et al. The effect of epineurotomy on the median nerve volume after the carpal tunnel release: a prospective randomised double-blind controlled trial. International Orthopaedics (SICOT) 36, 1885–1892 (2012). https://doi.org/10.1007/s00264-012-1565-y

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  • DOI: https://doi.org/10.1007/s00264-012-1565-y

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