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Risk factors for the incidence and progression of radiographic osteoarthritis of the knee among Japanese

International Orthopaedics volume 35, pages 839–843 (2011)Cite this article

Abstract

This longitudinal study aimed to identify risk factors for the incidence and progression of radiographic knee osteoarthritis (OA). We examined the inhabitants of Miyagawa village aged ≥65 years every two years between 1997 and 2007. Anteroposterior radiographs of both knees were graded for OA using the Kellgren-Lawrence (K/L) grading system. Knee OA was defined as grade ≥2. We recorded the incidence of knee OA among participants in whom both knees changed from K/L grades 0 or 1 to ≥2 over a four-year follow-up period. We also recorded the progression of knee OA using this threshold among patients in whom one or both knees changed from K/L grades 2 or 3 to any higher grade over the follow-up period. Baseline data obtained from standard questionnaires, physical findings and X-rays included age, gender, body mass index (BMI), osteoporosis, Heberden’s nodes, knee range of motion (ROM), knee pain and cigarette smoking. The rates of incidence and progression of knee OA among 360 participants (241 women, 119 men) who fulfilled the study criteria were 4.0 and 6.0% per year, respectively. Female gender (odds ratio [OR] 2.849, 95% confidence interval [CI] 1.170–6.944) and high BMI (OR 1.243, 95% CI 1.095–1.411) were significantly associated with the incidence of knee OA, and restricted knee ROM (OR 0.941, 95% CI 0.892–0.992) was significantly associated with knee OA progression. Patients with a low knee ROM relative to grade of radiographic knee OA require more careful follow-up than those with a higher ROM.

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References

  1. Salaffi F, Carotti M, Stancati A, Grassi W (2005) Health-related quality of life in older adults with symptomatic hip and knee osteoarthritis: a comparison with matched healthy controls. Aging Clin Exp Res 17:255–263

    PubMed  Google Scholar 

  2. Yoshimura N, Nishioka S, Kinoshita H, Hori N, Nishioka T, Ryujin M, Mantani Y, Miyake M, Coggon D, Cooper C (2004) Risk factors for knee osteoarthritis in Japanese women: heavy weight, previous joint injuries, and occupational activities. J Rheumatol 31:157–162

    PubMed  Google Scholar 

  3. Hart DJ, Doyle DV, Spector TD (1999) Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford study. Arthritis Rheum 42:17–24

    PubMed  Article  CAS  Google Scholar 

  4. Srikanth VK, Fryer JL, Zhai G, Winzenberg TM, Hosmer D, Jones G (2005) A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis. Osteoarthr Cartil 13:769–781

    PubMed  Article  Google Scholar 

  5. Sudo A, Miyamoto N, Horikawa K, Urawa M, Yamakawa T, Yamada T, Uchida A (2008) Prevalence and risk factors for knee osteoarthritis in elderly Japanese men and women. J Orthop Sci 13:413–418

    PubMed  Article  Google Scholar 

  6. Spector TD, Dacre JE, Harris PA, Huskisson EC (1992) Radiological progression of osteoarthritis: an 11 year follow up study of the knee. Ann Rheum Dis 51:1107–1110

    PubMed  Article  CAS  Google Scholar 

  7. Hernborg JS, Nilsson BE (1977) The natural course of untreated osteoarthritis of the knee. Clin Orthop Relat Res 123:130–137

    PubMed  Google Scholar 

  8. Felson DT, Zhang Y, Hannan MT, Naimark A, Weissman B, Aliabadi P, Levy D (1997) Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum 40:728–733

    PubMed  Article  CAS  Google Scholar 

  9. Slemenda C, Heilman DK, Brandt KD, Katz BP, Mazzuca SA, Braunstein EM, Byrd D (1998) Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women? Arthritis Rheum 41:1951–1959

    PubMed  Article  CAS  Google Scholar 

  10. Ledingham J, Regan M, Jones A, Doherty M (1995) Factors affecting radiographic progression of knee osteoarthritis. Ann Rheum Dis 54:53–58

    PubMed  Article  CAS  Google Scholar 

  11. Kellgren JH, Lawrence JS (1957) Radiological assessment of osteo-arthrosis. Ann Rheum Dis 16:494–502

    PubMed  Article  CAS  Google Scholar 

  12. Zhang Y, Hannan MT, Chaisson CE, McAlindon TE, Evans SR, Aliabadi P, Levy D, Felson DT (2000) Bone mineral density and risk of incident and progressive radiographic knee osteoarthritis in women: the Framingham study. J Rheumatol 27:1032–1037

    PubMed  CAS  Google Scholar 

  13. Cooper C, Snow S, McAlindon TE, Kellingray S, Stuart B, Coggon D, Dieppe PA (2000) Risk factors for the incidence and progression of radiographic knee osteoarthritis. Arthritis Rheum 43:995–1000

    PubMed  Article  CAS  Google Scholar 

  14. Felson DT (1988) Epidemiology of hip and knee osteoarthritis. Epidemiol Rev 10:1–28

    PubMed  CAS  Google Scholar 

  15. Coggon D, Croft P, Kellingray S, Barrett D, McLaren M, Cooper C (2000) Occupational physical activities and osteoarthritis of the knee. Arthritis Rheum 43:1443–1449

    PubMed  Article  CAS  Google Scholar 

  16. Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF (1987) The prevalence of knee osteoarthritis in the elderly. The Framingham osteoarthritis study. Arthritis Rheum 30:914–918

    PubMed  Article  CAS  Google Scholar 

  17. Felson DT, Hannan MT, Naimark A, Berkeley J, Gordon G, Wilson PW, Anderson J (1991) Occupational physical demands, knee bending, and knee osteoarthritis: results from the Framingham study. J Rheumatol 18:1587–1592

    PubMed  CAS  Google Scholar 

  18. Hannan MT, Anderson JJ, Zhang Y, Levy D, Felson DT (1993) Bone mineral density and knee osteoarthritis in elderly men and women. The Framingham study. Arthritis Rheum 36:1671–1680

    PubMed  Article  CAS  Google Scholar 

  19. Burger H, van Daele PL, Odding E, Valkenburg HA, Hofman A, Grobbee DE, Schutte HE, Birkenhager JC, Pols HA (1996) Association of radiographically evident osteoarthritis with higher bone mineral density and increased bone loss with age. The Rotterdam study. Arthritis Rheum 39:81–86

    PubMed  Article  CAS  Google Scholar 

  20. Sowers M, Lachance L, Jamadar D, Hochberg MC, Hollis B, Crutchfield M, Jannausch ML (1999) The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre-and perimenopausal women. Arthritis Rheum 42:483–489

    PubMed  Article  CAS  Google Scholar 

  21. Yoshimura N, Kinoshita H, Hori N, Nishioka T, Ryujin M, Mantani Y, Miyake M, Takeshita T, Ichinose M, Yoshiida M, Oka H, Kawaguchi H, Nakamura K, Cooper C (2006) Risk factors for knee osteoarthritis in Japanese men: a case-control study. Mod Rheumatol 16:24–29

    PubMed  Article  Google Scholar 

  22. Iwamoto J, Takeda T, Ichimura S (2002) Forearm bone mineral density in postmenopausal women with rheumatoid arthritis. Calcif Tissue Int 70:1–8

    PubMed  Article  CAS  Google Scholar 

  23. Felson DT, Zhang Y, Hannan MT, Naimark A, Weissman BN, Aliabadi P, Levy D (1995) The incidence and natural history of knee osteoarthritis in the elderly. The Framingham osteoarthritis study. Arthritis Rheum 38:1500–1505

    PubMed  Article  CAS  Google Scholar 

  24. Reijman M, Hazes JM, Pols HA, Bernsen RM, Koes BW, Bierma-Zeinstra SM (2005) Role of radiography in predicting progression of osteoarthritis of the hip: prospective cohort study. BMJ 330:1183

    PubMed  Article  Google Scholar 

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Affiliations

  1. Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu City, Mie, 514-8507, Japan

    Akinobu Nishimura, Masahiro Hasegawa, Ko Kato, Atsumasa Uchida & Akihiro Sudo

  2. Department of Translational Medical Science, Mie University Graduate School of Medicine, Tsu, Mie, Japan

    Tomomi Yamada

Authors
  1. Akinobu Nishimura
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  2. Masahiro Hasegawa
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  3. Ko Kato
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  4. Tomomi Yamada
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  5. Atsumasa Uchida
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  6. Akihiro Sudo
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Correspondence to Akinobu Nishimura.

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Nishimura, A., Hasegawa, M., Kato, K. et al. Risk factors for the incidence and progression of radiographic osteoarthritis of the knee among Japanese. International Orthopaedics (SICOT) 35, 839–843 (2011). https://doi.org/10.1007/s00264-010-1073-x

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  • DOI: https://doi.org/10.1007/s00264-010-1073-x

Keywords

  • Bone Mineral Density
  • Total Knee Arthroplasty
  • Total Knee Replacement
  • High Bone Mineral Density
  • Young Adult Mean