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Orthopaedic applications of gene therapy

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Abstract

Gene therapy presents a novel approach to biological treatment. Several orthopaedic diseases can cause changes in biological signalling at the tissue level that potentially can be repaired or modified by inserting genes into the cells or tissues to modulate gene expression. Impaired bone healing, need for extensive bone formation, cartilage repair and metabolic bone diseases are all conditions where alterations of the signalling peptides involved may provide cure or improvement. In orthopaedic oncology, gene therapy may achieve induction of tumour necrosis and increased tumour sensitivity to chemotherapy. In the last decade, extensive improvements have been made to optimise gene therapy and have been tested on several orthopaedic conditions. How far this development has come in orthopaedics is highlighted in this paper.

Résumé

La thérapie génique représente une nouvelle approche comme traitement biologique. Plusieurs maladies orthopédiques peuvent causer des changements au niveau des tissus qui potentiellement peuvent être réparés ou modifiés en insérant des gènes dans les cellules pour moduler l’expression du gène. Les maladies métaboliques sont des conditions ou l’altération de certains peptides particuliers peuvent fournir une guérison ou une amélioration. En oncologie la thérapie gènique peut améliorer la nécrose tumorale et accroitre la sensibilité de la tumeur à la chimiothérapie. Des améliorations importantes ont été faites dans la dernière décennie pour optimiser cette thérapie qui a été testée dans plusieurs conditions orthopédiques. Cet article envisage les développements actuels.

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Abbreviations

MSC:

Mesenchymal stem cell

IGF:

Insulin-like growth factor

BMP:

Bone morphogenetic protein

TGF-beta:

Transforming growth factor beta

OPG:

Osteoprotegerin

RANKL:

Receptor antagonist of the NF kappa beta ligand

CSF-1:

Colony stimulating factor-1

TIMP-1:

Tissue inhibitor of metalloproteinase

DDD:

Degenerative disc disease

PDGF:

Platelet-derived growth factor

LMP-1:

LIM mineralization protein 1

TRAIL:

TNF-related apoptosis-inducing ligand

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Authors and Affiliations

  1. Orthopaedic Research Laboratory, Orthopaedic Department E, Aarhus University Hospital, Nørrebrogade 44, 8000, Aarhus C, Denmark

    Martin Lind & Cody Bünger

  2. Hvedevangen 9, 8200, Århus N, Denmark

    Martin Lind

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  1. Martin Lind
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  2. Cody Bünger
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Correspondence to Martin Lind.

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Lind, M., Bünger, C. Orthopaedic applications of gene therapy. International Orthopaedics (SICOT) 29, 205–209 (2005). https://doi.org/10.1007/s00264-005-0650-x

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  • DOI: https://doi.org/10.1007/s00264-005-0650-x

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