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Desmoid tumours of the extremities and trunk: a review of the literature

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Abstract

Desmoid tumours are rare neoplasms that display local aggressiveness but no propensity to metastasise. They are mainly localized in the abdominal wall, the bowel, and the mesentery or in extra-abdominal sites such as the trunk and the extremities. Surgical resection is the main treatment modality in extremities and trunk, with the optional combination of radiotherapy and/or chemotherapy. However, these tumours have a high propensity for recurrent growth.

Résumé

Les tumeurs desmoides sont des néoplasmes rares qui ont un caractère agressif local, mais aucune propension à métastaser. Elles sont principalement localisés dans la paroi abdominale, l’intestin et le mésentère et dans des sites extra-abdominaux tels que le tronc et les extrémités. La résection chirurgicale est la principale modalité du traitement pour les extrémités et le tronc avec la combinaison facultative de radiothérapie et/ou chimiothérapie. Cependant, ils ont une haute tendance à la récidive.

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References

  1. Azzarelli A, Gronchi A, Bertulli R, Tesoro JD, Baratti D, Pennacchioli E, Dileo P, Rasponi A, Ferrari A, Pilotti S, Casali PG (2001) Low-dose chemotherapy with methotrexate and vinblastine for patients with advanced aggressive fibromatosis. Cancer 92:1259–1264

    Article  CAS  PubMed  Google Scholar 

  2. Ballo MT, Zagars GK, Pollack A, Pisters PW, Pollack RA (1999) Desmoid tumor: prognostic factors and outcome after surgery, radiation therapy, or combined surgery and radiation therapy. J Clin Oncol 17:158–167

    CAS  PubMed  Google Scholar 

  3. Bernard J, Le Breton C, Piriou P, Khalil A, Boumenir Z, Cortez A, Carette MF, Bigot JM, Judet T (2002) Value of MRI to evaluate extra-abdominal desmoid fibromatosis. J Radiol 83:711–716

    CAS  PubMed  Google Scholar 

  4. Bridge JA, Sreekantaiah C, Mouron B, Neff JR, Sandberg AA, Wolman SR (1992) Clonal chromosomal abnormalities in desmoid tumors. Implications for histopathogenesis. Cancer 69:430–436

    CAS  PubMed  Google Scholar 

  5. Duggal A, Dickinson IC, Sommerville S, Gallie P (2004) The management of extra-abdominal desmoid tumors. Int Orthop 28:252–256

    Article  PubMed  Google Scholar 

  6. Edmonds LD, Ly JQ, LaGatta LM, Lusk JD, Beall DP (2003) Quiz case. Extraabdominal desmoid tumor of the upper arm. Eur J Radiol 48:312–315

    Article  PubMed  Google Scholar 

  7. Gronchi A, Casali PG, Mariani L, Lo Vullo S, Colecchia M, Lozza L, Bertulli R, Fiore M, Olmi P, Santinami M, Rosai J (2003) Quality of surgery and outcome in extra-abdominal aggressive fibromatosis: a series of patients surgically treated at a single institution. J Clin Oncol 21:1390–1397

    Article  CAS  PubMed  Google Scholar 

  8. Kingston CA, Owens CM, Jeanes A, Malone M (2002) Imaging of desmoid fibromatosis in pediatric patients. Am J Roentgenol 178:191–199

    Google Scholar 

  9. Kobayashi H, Kotoura Y, Hosono M, Tsuboyama T, Sakahara H, Endo K, Konishi J (1997) MRI and scintigraphic features of extraabdominal desmoid tumors. Clin Imaging 21:35–39

    Article  CAS  PubMed  Google Scholar 

  10. Leithner A, Schnack B, Katterschafka T, Wiltschke C, Amann G, Windhager R, Kotz R, Zielinski CC (2000) Treatment of extra-abdominal desmoid tumors with interferon-alpha with or without tretinoin. J Surg Oncol 73:21–25

    Article  CAS  PubMed  Google Scholar 

  11. Leithner A, Gapp M, Leithner K, Radl R, Krippl P, Beham A, Windhager R (2004) Margins in extra-abdominal desmoid tumors: a comparative analysis. J Surg Oncol 86:152–156

    Article  PubMed  Google Scholar 

  12. Lewis JJ, Boland PJ, Leung DH, Woodruff JM, Brennan MF (1999) The enigma of desmoid tumors. Ann Surg 229:866–872

    Article  CAS  PubMed  Google Scholar 

  13. Mace J, Biermann JS, Sondak V, McGinn C, Hayes C, Thomas D, Baker L (2002) Response of extra-abdominal desmoid tumors to therapy with Imatinib Me4sylate. Cancer 95:2373–2379

    Article  CAS  PubMed  Google Scholar 

  14. Merchant NB, Lewis JJ, Woodruff JM, Leung DH, Brennan MF (1999) Extremity and trunk desmoid tumors: a multifactorial analysis of outcome. Cancer 86:2045–2052

    Article  CAS  PubMed  Google Scholar 

  15. Mills BG, Frausto A, Brien E (2000) Cytokines associated with the pathophysiology of aggressive fibromatosis. J Orthop Res 18:655–662

    Article  CAS  PubMed  Google Scholar 

  16. Nuyttens JJ, Rust PF, Thomas CR Jr, Turrisi AT III (2000) Surgery versus radiation therapy for patients with aggressive fibromatosis or desmoid tumors: a comparative review of 22 articles. Cancer 88:1517–1523

    Article  CAS  PubMed  Google Scholar 

  17. Pritchard DJ, Nascimento AG, Petersen IA (1996) Local control of extra-abdominal desmoid tumors. J Bone Joint Surg Am 78:848–854

    CAS  PubMed  Google Scholar 

  18. Reitamo JJ, Hayry P, Nykyri E, Saxen E (1982) The desmoid tumor. I. Incidence, sex-, age- and anatomical distribution in the Finnish population. Am J Clin Pathol 77:665–673

    CAS  PubMed  Google Scholar 

  19. Rock MG, Pritchard DJ, Reiman HM, Soule EH, Brewster RC (1984) Extra-abdominal desmoid tumors. J Bone Joint Surg Am 66:1369–1374

    CAS  PubMed  Google Scholar 

  20. Shields CJ, Winter DC, Kirwan WO, Redmond HP (2001) Desmoid tumors. Eur J Surg Oncol 27:701–706

    Article  CAS  PubMed  Google Scholar 

  21. Skapek SX, Hawk BJ, Hoffer FA, Dahl GV, Granowetter L, Gebhardt MC, Ferguson WS, Grier HE (1998) Combination chemotherapy using vinblastine and methotrexate for the treatment of progressive desmoid tumor in children. J Clin Oncol 16:3021–3027

    CAS  PubMed  Google Scholar 

  22. Tonelli F, Valanzano R, Brandi ML (1994) Pharmacologic treatment of desmoid tumors in familial adenomatous polyposis: results of an in vitro study. Surgery 115:473–479

    CAS  PubMed  Google Scholar 

  23. Waddell WR, Kirsch WM (1991) Testolactone, sulindac, warfarin, and vitamin K1 for unresectable desmoid tumors. Am J Surg 161:416–421

    Article  CAS  PubMed  Google Scholar 

  24. Zlotecki RA, Scarborough MT, Morris CG, Berrey BH, Lind DS, Enneking WF, Marcus RB Jr (2002) External beam radiotherapy for primary and adjuvant management of aggressive fibromatosis. Int J Radiat Oncol Biol Phys 54:177–181

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Therapy, University Hospital of Ioannina, School of Medicine, University of Ioannina, Ioannina, Greece

    Emilios E. Pakos & Pericles G. Tsekeris

  2. Department of Pathology, University Hospital of Ioannina, School of Medicine, University of Ioannina, Ioannina, Greece

    Ann C. Goussia

  3. Neohoropoulo, P.O.Box 243, Ioannina, 45500, Greece

    Emilios E. Pakos

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  1. Emilios E. Pakos
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  2. Pericles G. Tsekeris
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  3. Ann C. Goussia
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Correspondence to Emilios E. Pakos.

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Pakos, E.E., Tsekeris, P.G. & Goussia, A.C. Desmoid tumours of the extremities and trunk: a review of the literature. International Orthopaedics (SICOT) 29, 210–213 (2005). https://doi.org/10.1007/s00264-005-0641-y

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  • DOI: https://doi.org/10.1007/s00264-005-0641-y

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