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Tranexamic acid reduces blood loss after cementless total hip arthroplasty—prospective randomized study in 40 cases

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We investigated the effects of tranexamic acid in 40 patients who had received cementless total hip arthroplasty (THA) in a prospective, randomized study. In 20 patients, 1000 mg of whole-body tranexamic acid was administered intravenously 5 min before the operation started. The other 20 patients served as a control group and were operated on without tranexamic acid. Perioperative blood loss was similar in the tranexamic acid group and in the control group. Postoperative blood loss of the tranexamic acid group was significantly less than that of the control group at 2, 4, 6, 8, 10, and 12 h. Regarding time-related changes of postoperative blood loss, significant reduction was observed during the first 2 h after surgery in the tranexamic acid group (P<0.001). After the first 2 h, there was no significant difference between the tranexamic acid group and the control group. Preoperative administration of tranexamic acid decreased postoperative blood loss until 12 h and total bleeding in cementless THA by reduction of blood loss during the first 2 h after surgery.


Dans une étude prospective et randomisée nous avons enquêté sur les effets de l’acide tranéxamique chez 40 malades qui avaient reçu une PTH sans ciment. Chez 20 malades, 1000 mg/d’acide tranéxamique ont été administré par voie intraveineuse cinq minutes avant l’opération. Les autres 20 malades ont fait office de groupe témoin et ont été opérés sans acide tranéxamique. La perte de sang peropératoire était semblable dans le groupe acide tranéxamique et dans le groupe témoin. La perte de sang postopératoire du groupe acide tranéxamique était notablement plus faible que celle du groupe témoin à 2, 4, 6, 8, 10, et 12 heures postopératoires. En considérant les modifications de la perte sanguine en fonction du temps postopératoire, une réduction significative a été observée dans les deux premières heures dans le groupe acide tranexamique (P<0.001). Après les 2 premières heures, il n’y avait pas de différence entre le groupe acide tranéxamique et le groupe témoin. L’administration préopératoire d’acide tranéxamique a diminué la perte de sang postopératoire jusqu’à 12 heures et le saignement total dans les PTH sans ciment par réduction du saignement pendant les 2 premières heures après chirurgie.

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Correspondence to Satoshi Yamasaki.

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Yamasaki, S., Masuhara, K. & Fuji, T. Tranexamic acid reduces blood loss after cementless total hip arthroplasty—prospective randomized study in 40 cases. International Orthopaedics (SICOT) 28, 69–73 (2004).

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