Abstract
We studied the appearance and frequency of the medial epiarticular osteophyte in human femoral heads. Specimens were sampled from 24 men and 31 women who underwent total hip arthroplasty. On radiography, medial epiarticular osteophytes were present in two thirds of the cases. However, histological examination revealed endochondral ossification in all. Presumably, the bone formation was preceded by the formation of canals and cavities containing vessels. Due to the ossification around these canals and cavities, the histological picture frequently featured two layers of cartilage with bone in the middle. Also in the marginal osteophytes, bone was formed by endochondral ossification. However, this bone appeared more irregular. The new bone formation most likely indicates a reactivated growth as an attempt to repair the osteoarthritic lesions rather than a process of degradation.
Résumé
Nous avons étudié l'apparence et la fréquence de l'ostéophyte épiarticulaire médial dans les têtes fémorales humaines. Les spécimens ont été prélevés chez 24 hommes et 31 femmes qui ont subi une arthroplastie totale de la hanche. Sur les radiographies, ces ostéophytes étaient présents dans deux cas sur trois et l'examen histologique a révélé de l'ossification endochondrale dans tous les cas. Vraisemblablement la formation de l'os a été précédée par la formation de canaux et cavités qui contiennent des vaisseaux. A cause de l'ossification autour ces canaux et cavités, l'image histologique a fréquemment montré deux couches de cartilage entourant une couche osseuse. Dans les ostéophytes marginaux, l'os a aussi été formé par ossification endochondrale. Cependant, cet os a paru plus irrégulier. La nouvelle formation osseuse indique très probablement une croissance réactivée comme une tentative pour réparer les lésions arthrosiques, plutôt qu'un processus de dégénération.
Similar content being viewed by others
References
Amir G, Pirie CJ, Rashad S, Revell PA (1992) Remodeling of subchondral bone in osteoarthritis: a histomorphometric study. J Clin Pathol 45:990–992
Brandt KD, Schauwecker DS, Danserau S, Mejer J, O´Conner B, Myers SL (1997) Bone scintigraphy in the canine cruciate deficient model of osteoarthritis. Comparison of the unstable and contralateral knee. J Rheumatol 24:140–145
Bullough PG, Jagannath A (1983) The morphology of the calcification front in articular cartilage. Its significance in joint function. J Bone Joint Surg [Br] 65:72–78
Burkus JK, Ganey TM, Ogden JA (1993) Development of the cartilage canals and the secondary center of ossification in the distal chondroepiphysis of the prenatal human femur. Yale J Biol Med 66:193–202
Burr DB, Schaffler MB (1997) The involvement of subchondral mineralized tissues in osteoarthrosis: quantitative microscopic evidence. Microsc Res Tech 37:343–357
Christensen SB, Arnoldi CC (1980) Distribution of 99mTc-phosphate compounds in osteoarthritic femoral heads. J Bone Joint Surg [Am] 62:90–96
Christensen SB (1985) Osteoarthrosis. Changes of bone, cartilage and synovial membrane in relation to bone scintigraphy. Acta Orthop Scand [Suppl]:214
Connor JR, Dodds RA, Emery JG, Kirkpatrick RB, Rosenberg M, Gowen M (2000) Human cartilage glycoprotein 39 (HC gp-39) mRNA expression in adult and fetal chondrocytes, osteoblasts and osteocytes by in-situ hybridization. Osteoarthritis Cartilage 8:87–95
de Bri E, Reinholt FP, Svensson O (1995) Primary osteoarthritis in guinea pigs: a stereological study. J Orthop Res 13:769–776
Dieppe P, Cushnaghan J, Young P, Kirwan J (1993) Prediction of the progression of joint space narrowing i osteoarthritis of the knee by bone scintigraphy. Ann Rheum Dis 52:557–563
Dodds RA, Merry K, Littlewood A, Gowen M (1994) Expression of mRNA for IL1β, IL6 and TGF-β1 in developing human bone and cartilage. J Histochem Cytochem 42:733–744
Grynpas MD, Alpert B, Katz I, Lieberman I, Pritzker KP (1991) Subchondral bone in osteoarthritis. Calcif Tissue Int 49:20–26
Harrison MHM, Schajowics F, Trueta J (1953) Osteoarthritis of the hip : a study of the nature and evolution of the disease. J Bone Joint Surg [Br] 35:598–609
Hulth A, Johnell O, Nilsson B (1995) Osteoarthrosis and late growth. Clin Orthop 313:159–168
Jeffery AK (1975) Osteophytes and the osteoarthritic femoral head. J Bone Joint Surg [Br] 57:314–324
Jeffery AK (1973) Osteogenesis in the osteoarthritic femoral head. A study using Radioactive32P and Tetracycline Bone markers. J Bone Joint Surg [Br] 55:262–272
Johnson LC (1959) Kinetics of osteoarthritis. Lab Invest 8:1223–1241
Lane LB, Villacin A, Bullough PG (1977) The vascularity and remodeling of subchondral bone and calcified cartilage in adult human femoral and humeral heads. J Bone Joint Surg [Br] 19:272–278
Matsui H, Shimizu M, Tsuji H (1997) Cartilage and subchondral bone interaction in osteoarthrosis of human knee joint: a histological and histomorphometric study. Microsc Res Tech 37:333–342
Nelson F, Dahlberg L, Laverty S, Reiner A, Pidoux I, Ionescu M, et al (1998) Evidence for altered synthesis of type II collagen in patients with osteoarthritis. J Clin Invest 102:2115–2125
Oegema TR Jr,Carpenter RJ, Hofmeister F, Thompson RC Jr (1997) The interaction of the zone of calcified cartilage and subchondral bone in osteoarthritis. Microsc Res Tech 37:324–332
Poole AR (1997) Cartilage in health and disease. In: Koopman W (ed), Arthritis and allied conditions. Williams & Wilkins, Baltimore, pp 253–308
Uchino M, Izumi T, Tominaga T, Wakita R, Minehara H, Sekiguchi M, Itoman M(2000) Growth factor expression in the osteophytes of the human femoral head in osteoarthritis. Clin Orthop 377:119–125
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Neuman, P., Hulth, A., Lindén, B. et al. The role of osteophytic growth in hip osteoarthritis. International Orthopaedics (SICOT) 27, 262–266 (2003). https://doi.org/10.1007/s00264-003-0485-2
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00264-003-0485-2