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Genetic susceptibility to cervical squamous cell carcinoma is associated with HLA-DPB1 polymorphisms in Taiwanese women

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Abstract

Cervical cancer is a multifactorial disease, and increasing evidence suggests that host immunogenetic background may contribute to its pathogenesis. Genetic variations in human leukocyte antigen (HLA) genes may alter the efficiency of immune response to human papillomavirus (HPV) antigens and have been implicated in the risk of cervical cancer. We investigated whether polymorphisms in the HLA-DPB1 gene were associated with cervical cancer risk in a Taiwanese population. HLA-DPB1 alleles and +550 G/A polymorphism were genotyped in a case–control study of 473 women with cervical squamous cell carcinoma (CSCC) and 676 healthy controls. The presence and genotypes of HPV in CSCC were determined. We found that the DPB1*05:01 and +550 A alleles were associated with decreased and increased risk of CSCC, respectively [odds ratio (OR) = 0.72, P c = 0.001; OR = 1.25, P c = 0.03]. In subgroup analysis based on HPV type 16 positivity, significant associations were shown in the DPB1*05:01 and *13:01 alleles (OR = 0.65, P c = 0.0007; OR = 1.83, P c = 0.004). Furthermore, the DPB1*05:01-G and *13:01-G haplotypes conferred decreased and increased risk of both CSCC and HPV-16 positive CSCC women, respectively (OR = 0.72, P c = 0.0009; OR = 0.63, P c = 0.0004 for DPB1*05:01-G; OR = 1.55, P c = 0.03; OR = 1.84, P c = 0.004 for DPB1*13:01-G). A risk haplotype DPB1*02:01-A was also observed in the HPV-16 positive CSCC women (OR = 1.51, P c = 0.05). These findings suggest that HLA-DPB1 gene is involved in the CSCC development.

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Abbreviations

CI:

Confidence interval

CSCC:

Cervical squamous cell carcinoma

HLA:

Human leukocyte antigen

HPV:

Human papillomavirus

LD:

Linkage disequilibrium

OR:

Odds ratio

PCR:

Polymerase chain reaction

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Acknowledgments

This research was supported by Grants MMH 9781 and MMH E-103-07 from Mackay Memorial Hospital, Taiwan.

Conflict of interest

The authors declare that they have no conflict of interest.

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Author notes

    Authors and Affiliations

    1. Department of Gynecology and Obstetrics, Mackay Memorial Hospital, Taipei City, Taiwan

      Yuh-Cheng Yang & Tze-Chien Chen

    2. Department of Pediatrics, Mackay Memorial Hospital, Taipei City, Taiwan

      Yann-Jinn Lee

    3. Department of Medical Research, Mackay Memorial Hospital, New Taipei City, Taiwan

      Tzu-Yang Chang, Wen-Shan Lin, Shih-Chuan Chang & Yann-Jinn Lee

    4. Department of Gynecology and Obstetrics, Taipei Medical University, Taipei City, Taiwan

      Yuh-Cheng Yang

    5. Department of Pediatrics, Taipei Medical University, Taipei City, Taiwan

      Yann-Jinn Lee

    6. Institute of Biomedical Sciences and Department of Medicine, Mackay Medical College, New Taipei City, Taiwan

      Yann-Jinn Lee

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    1. Yuh-Cheng Yang
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    Correspondence to Yann-Jinn Lee.

    Additional information

    Yuh-Cheng Yang and Tzu-Yang Chang have contributed equally to this work.

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    Yang, YC., Chang, TY., Chen, TC. et al. Genetic susceptibility to cervical squamous cell carcinoma is associated with HLA-DPB1 polymorphisms in Taiwanese women. Cancer Immunol Immunother 64, 1151–1157 (2015). https://doi.org/10.1007/s00262-015-1721-5

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    • DOI: https://doi.org/10.1007/s00262-015-1721-5

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