Cancer Immunology, Immunotherapy

, Volume 63, Issue 9, pp 969–975 | Cite as

Engineered T cells for cancer therapy

  • Carl H. JuneEmail author
  • Marcela V. Maus
  • Gabriela Plesa
  • Laura A. Johnson
  • Yangbing Zhao
  • Bruce L. Levine
  • Stephan A. Grupp
  • David L. Porter
Focussed Research Review


It is now well established that the immune system can control and eliminate cancer cells. Adoptive T cell transfer has the potential to overcome the significant limitations associated with vaccine-based strategies in patients who are often immune compromised. Application of the emerging discipline of synthetic biology to cancer, which combines elements of genetic engineering and molecular biology to create new biological structures with enhanced functionalities, is the subject of this focused research review.


Adoptive cell transfer Gene transfer Leukemia Chimeric antigen receptor 19th Danish Cancer Society Symposium 



The authors declare sponsored research support from Novartis.

Conflict of interest

The authors have intellectual property in this field that is owned by the University of Pennsylvania, and licensed by Novartis.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Carl H. June
    • 1
    • 4
    Email author
  • Marcela V. Maus
    • 1
    • 2
  • Gabriela Plesa
    • 1
  • Laura A. Johnson
    • 1
    • 4
  • Yangbing Zhao
    • 1
    • 4
  • Bruce L. Levine
    • 1
    • 4
  • Stephan A. Grupp
    • 1
    • 3
  • David L. Porter
    • 1
    • 2
  1. 1.Abramson Cancer CenterUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of Medicine, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Division of OncologyChildren’s Hospital of PhiladelphiaPhiladelphiaUSA
  4. 4.Department of Pathology and Laboratory Medicine, Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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