Cancer Immunology, Immunotherapy

, Volume 59, Issue 5, pp 799–803 | Cite as

Naturally occurring systemic immune responses to HPV antigens do not predict regression of CIN2/3

  • Cornelia L. TrimbleEmail author
  • Shiwen Peng
  • Christopher Thoburn
  • Ferdynand Kos
  • T. C. Wu
Short Communication


Essentially all squamous cervical cancers and their precursor lesions, high grade cervical intraepithelial neoplasia (CIN2/3), are caused by persistent human papillomavirus (HPV) infection. However, not all CIN2/3 lesions progress to cancer. In a brief, observational study window monitoring subjects with CIN2/3 from protocol entry (biopsy diagnosis) to definitive therapy (cervical conization) at week 15, in a cohort of 50 subjects, we found that 26% of CIN2/3 lesions associated with HPV16, the genotype most commonly associated with disease, underwent complete histologic regression. Nonetheless, HPV16-specific T cell responses measured in peripheral blood obtained at the time of study entry and at the time of conization were marginally detectable directly ex vivo, and did not correlate with lesion regression. This finding suggests that, in the setting of natural infection, immune responses which are involved in elimination of cervical dysplastic epithelium are not represented to any great extent in the systemic circulation.


Human papillomavirus (HPV) Cervical dysplasia Regression Systemic immune response 



Human papillomavirus


Cervical intraepithelial neoplasia


Squamous cervical cancer


Peripheral blood mononuclear cells


Enzyme-linked immunosorbent spot assay



This work was supported by the National Institutes of Health (P50 CA098252) and by the Dana Foundation (CLT).


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Cornelia L. Trimble
    • 1
    Email author
  • Shiwen Peng
    • 3
  • Christopher Thoburn
    • 2
  • Ferdynand Kos
    • 2
  • T. C. Wu
    • 3
  1. 1.Department of Gynecology and ObstetricsJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of OncologyJohns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Department of PathologyJohns Hopkins University School of MedicineBaltimoreUSA

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