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Strategies for immune intervention; from bench to bedside

Symposium 2006 of the Collaborative Research Center “Strategies of cellular immune intervention” July 17th–18th, Erlangen, Germany

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Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

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References

  1. Acero R, Polentarutti N, Bottazzi B, Alberti S, Ricci MR, Bizzi A, Mantovani A (1984) Effect of hydrocortisone on the macrophage content, growth and metastasis of transplanted murine tumors. Int J Cancer 33:95–105

    Article  PubMed  CAS  Google Scholar 

  2. Bender H, Grapow M, Schomburg A, Reinhold U, Biersack HJ (1997) Effects of diagnostic application of monoclonal antibody on survival in melanoma patients. Hybridoma 16:65–68

    PubMed  CAS  Google Scholar 

  3. Berd D, Mastrangelo MJ (1987) Effect of low dose cyclophosphamide on the immune system of cancer patients: reduction of T-suppressor function without depletion of the CD8+ subset. Cancer Res 47:3317–3321

    PubMed  CAS  Google Scholar 

  4. Bronte V, Serafini P, Mazzoni A, Segal DM, Zanovello P (2003) L-arginine metabolism in myeloid cells controls T-lymphocyte functions. Trends Immunol 24:302–306

    Article  PubMed  CAS  Google Scholar 

  5. Campoli MR, Chang CC, Kageshita T, Wang X, McCarthy JB, Ferrone S (2004) Human high molecular weight-melanoma-associated antigen (HMW-MAA): a melanoma cell surface chondroitin sulfate proteoglycan (MSCP) with biological and clinical significance. Crit Rev Immunol 24:267–296

    Article  PubMed  CAS  Google Scholar 

  6. Casares N, Pequignot MO, Tesniere A, Ghiringhelli F, Roux S, Chaput N, Schmitt E, Hamai A, Hervas-Stubbs S, Obeid M, Coutant F, Metivier D, Pichard E, Aucouturier P, Pierron G, Garrido C, Zitvogel L, Kroemer G (2005) Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med 202:1691–1701

    Article  PubMed  CAS  Google Scholar 

  7. Chekenya M, Hjelstuen M, Enger PO, Thorsen F, Jacob AL, Probst B, Haraldseth O, Pilkington G, Butt A, Levine JM, Bjerkvig R (2002) NG2 proteoglycan promotes angiogenesis-dependent tumor growth in CNS by sequestering angiostatin. FASEB J 16:586–588

    PubMed  CAS  Google Scholar 

  8. Dannull J, Su Z, Rizzieri D, Yang BK, Coleman D, Yancey D, Zhang A, Dahm P, Chao N, Gilboa E, Vieweg J (2005) Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest 115:3623–3633

    Article  PubMed  CAS  Google Scholar 

  9. Edinger M, Hoffmann P, Ermann J, Drago K, Fathman CG, Strober S, Negrin RS (2003) CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 9:1144–1150

    Article  PubMed  CAS  Google Scholar 

  10. Ermann J, Hoffmann P, Edinger M, Dutt S, Blankenberg FG, Higgins JP, Negrin RS, Fathman CG, Strober S (2005) Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood 105:2220–2226

    Article  PubMed  CAS  Google Scholar 

  11. Ferrone S, Chen ZJ, Liu CC, Hirai S, Kageshita T, Mittelman A (1993) Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic monoclonal antibodies MK2–23. Experimental studies and clinical trials in patients with malignant melanoma. Pharmacol Ther 57:259–290

    Article  PubMed  CAS  Google Scholar 

  12. Gabrilovich DI, Bronte V, Chen SH, Colombo MP, Ochoa A, Ostrand-Rosenberg S, Schreiber H (2007) The terminology issue for myeloid-derived suppressor cells. Cancer Res 67:425

    Article  PubMed  CAS  Google Scholar 

  13. Gallina G, Dolcetti L, Serafini P, De Santo C, Marigo I, Colombo MP, Basso G, Brombacher F, Borrello I, Zanovello P, Bicciato S, Bronte V (2006) Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells. J Clin Invest 116:2777–2790

    Article  PubMed  CAS  Google Scholar 

  14. Ghose T, Ferrone S, Blair AH, Kralovec Y, Temponi M, Singh M, Mammen M (1991) Regression of human melanoma xenografts in nude mice injected with methotrexate linked to monoclonal antibody 225.28 to human high molecular weight-melanoma associated antigen. Cancer Immunol Immunother 34:90–96

    Article  PubMed  CAS  Google Scholar 

  15. Gorski KS, Waller EL, Bjornton-Severson J, Hanten JA, Riter CL, Kieper WC, Gorden KB, Miller JS, Vasilakos JP, Tomai MA, Alkan SS (2006) Distinct indirect pathways govern human NK-cell activation by TLR-7 and TLR-8 agonists. Int Immunol 18:1115–1126

    Article  PubMed  CAS  Google Scholar 

  16. Hafner C, Wagner S, Allwardt D, Riemer AB, Scheiner O, Pehamberger H, Breiteneder H (2005) Cross-reactivity of mimotopes with a monoclonal antibody against the high molecular weight melanoma-associated antigen (HMW-MAA) does not predict cross-reactive immunogenicity. Melanoma Res 15:111–117

    Article  PubMed  CAS  Google Scholar 

  17. Hill GR, Ferrara JL (2000) The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood 95:2754–2759

    PubMed  CAS  Google Scholar 

  18. Hjortland GO, Garman-Vik SS, Juell S, Olsen OE, Hirschberg H, Fodstad O, Engebraaten O (2004) Immunotoxin treatment targeted to the high-molecular-weight melanoma-associated antigen prolonging the survival of immunodeficient rats with invasive intracranial human glioblastoma multiforme. J Neurosurg 100:320–327

    Article  PubMed  CAS  Google Scholar 

  19. Hoffmann P, Boeld TJ, Eder R, Albrecht J, Doser K, Piseshka B, Dada A, Niemand C, Assenmacher M, Orso E, Andreesen R, Holler E, Edinger M (2006) Isolation of CD4+CD25+ regulatory T cells for clinical trials. Biol Blood Marrow Transplant 12:267–274

    Article  PubMed  CAS  Google Scholar 

  20. Hoffmann P, Eder R, Boeld TJ, Doser K, Piseshka B, Andreesen R, Edinger M (2006) Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 108:4260–4267

    Article  PubMed  CAS  Google Scholar 

  21. Hoffmann P, Eder R, Kunz-Schughart LA, Andreesen R, Edinger M (2004) Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells. Blood 104:895–90

    Article  PubMed  CAS  Google Scholar 

  22. Hoffmann P, Ermann J, Edinger M, Fathman CG, Strober S (2002) Donor-type CD4 (+) CD25 (+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med 196:389–399

    Article  PubMed  CAS  Google Scholar 

  23. Kiyokawa T, Williams DP, Snider CE, Strom TB, Murphy JR (1991) Protein engineering of diphtheria-toxin-related interleukin-2 fusion toxins to increase cytotoxic potency for high-affinity IL-2-receptor-bearing target cells. Protein Eng 4:463–468

    Article  PubMed  CAS  Google Scholar 

  24. Lewis C, Murdoch C (2005) Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol 167:627–635

    PubMed  CAS  Google Scholar 

  25. Mantovani A (1978) Effects on in vitro tumor growth of murine macrophages isolated from sarcoma lines differing in immunogenicity and metastasizing capacity. Int J Cancer 22:741–746

    Article  PubMed  CAS  Google Scholar 

  26. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25:677–686

    Article  PubMed  CAS  Google Scholar 

  27. Matsui M, Nakanishi T, Noguchi T, Imai K, Yachi A, Ferrone S (1985) Suppression of human melanoma growth in nude mice injected with anti high-molecular-weight melanoma-associated antigen monoclonal antibody 225.28S conjugated to purothionin. Jpn J Cancer Res 76:119–123

    PubMed  CAS  Google Scholar 

  28. Mittelman A, Chen GZ, Wong GY, Liu C, Hirai S, Ferrone S (1995) Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2–23: modulation of the immunogenicity in patients with malignant melanoma. Clin Cancer Res 1:705–713

    PubMed  CAS  Google Scholar 

  29. Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini JL, Castedo M, Mignot G, Panaretakis T, Casares N, Metivier D, Larochette N, van Endert P, Ciccosanti F, Piacentini M, Zitvogel L, Kroemer G (2007) Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med 13:54–61

    Article  PubMed  CAS  Google Scholar 

  30. Palamara F, Meindl S, Holcmann M, Luhrs P, Stingl G, Sibilia M (2004) Identification and characterization of pDC-like cells in normal mouse skin and melanomas treated with imiquimod. J Immunol 173:3051–3061

    PubMed  CAS  Google Scholar 

  31. Peng G, Guo Z, Kiniwa Y, Voo KS, Peng W, Fu T, Wang DY, Li Y, Wang HY, Wang RF (2005) Toll-like receptor 8-mediated reversal of CD4+ regulatory T cell function. Science 309:1380–1384

    Article  PubMed  CAS  Google Scholar 

  32. Schioppa T, Uranchimeg B, Saccani A, Biswas SK, Doni A, Rapisarda A, Bernasconi S, Saccani S, Nebuloni M, Vago L, Mantovani A, Melillo G, Sica A (2003) Regulation of the chemokine receptor CXCR4 by hypoxia. J Exp Med 198:1391–1402

    Article  PubMed  CAS  Google Scholar 

  33. Seddiki N, Santner-Nanan B, Tangye SG, Alexander SI, Solomon M, Lee S, Nanan R, Saint Groth BF (2006) Persistence of naive CD45RA+ regulatory T cells in adult life. Blood 107: 2830–2838

    Article  PubMed  CAS  Google Scholar 

  34. Serafini P, Borrello I, Bronte V (2006) Myeloid suppressor cells in cancer: recruitment, phenotype, properties, and mechanisms of immune suppression. Semin Cancer Biol 16:53–6

    Article  PubMed  CAS  Google Scholar 

  35. Serafini P, Meckel K, Kelso M, Noonan K, Califano J, Koch W, Dolcetti L, Bronte V, Borrello I (2006) Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function. J Exp Med 203:2691–2702

    Article  PubMed  CAS  Google Scholar 

  36. Sica A, Saccani A, Bottazzi B, Polentarutti N, Vecchi A, van Damme J, Mantovani A (2000) Autocrine production of IL-10 mediates defective IL-12 production and NF-kappa B activation in tumor-associated macrophages. J Immunol 164:762–767

    PubMed  CAS  Google Scholar 

  37. Sidky YA, Borden EC, Weeks CE, Reiter MJ, Hatcher JF, Bryan GT (1992) Inhibition of murine tumor growth by an interferon-inducing imidazoquinolinamine. Cancer Res 52:3528–3533

    PubMed  CAS  Google Scholar 

  38. Valmori D, Merlo A, Souleimanian NE, Hesdorffer CS, Ayyoub M (2005) A peripheral circulating compartment of natural naive CD4 Tregs. J Clin Invest 115:1953–1962

    Article  PubMed  CAS  Google Scholar 

  39. Wagner S, Hafner C, Allwardt D, Jasinska J, Ferrone S, Zielinski CC, Scheiner O, Wiedermann U, Pehamberger H, Breiteneder H (2005) Vaccination with a human high molecular weight melanoma-associated antigen mimotope induces a humoral response inhibiting melanoma cell growth in vitro. J Immunol 174:976–982

    PubMed  CAS  Google Scholar 

  40. Yang J, Price MA, Neudauer CL, Wilson C, Ferrone S, Xia H, Iida J, Simpson MA, McCarthy JB (2004) Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms. J Cell Biol 165:881–891

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

We thank Prof. Eckhart Kämpgen and all referred speakers for critically reading the manuscript, Prof Gerold Schuler and Brigitte Wölfel for organizing this SFB meeting and all speakers for the interesting presentations.

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Authors and Affiliations

  1. Department Dermatology, University Hospital Erlangen, Hartmannstrasse 14, 91052, Erlangen, Germany

    Jan Dörrie, Katrin Birkholz & Niels Schaft

Authors
  1. Jan Dörrie
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  2. Katrin Birkholz
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  3. Niels Schaft
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Corresponding author

Correspondence to Niels Schaft.

Additional information

Jan Dörrie, Katrin Birkholz, Niels Schaft have contributed equally.

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Dörrie, J., Birkholz, K. & Schaft, N. Strategies for immune intervention; from bench to bedside. Cancer Immunol Immunother 56, 1677–1685 (2007). https://doi.org/10.1007/s00262-007-0311-6

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  • DOI: https://doi.org/10.1007/s00262-007-0311-6

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