Cancer Immunology, Immunotherapy

, Volume 55, Issue 4, pp 404–411 | Cite as

Efficacy of adjuvant Immunochemotherapy with polysaccharide K for patients with curatively resected colorectal cancer: a meta-analysis of centrally randomized controlled clinical trials

  • Junichi Sakamoto
  • Satoshi Morita
  • Koji Oba
  • Takanori Matsui
  • Michiya Kobayashi
  • Hiroaki Nakazato
  • Yasuo Ohashi
  • Meta-Analysis Group of the Japanese Society for Cancer of the Colon Rectum
Original Article

Abstract

The benefits of immunochemotherapy employing the biological response modifier polysaccharide K (PSK) for patients with curatively resected colorectal cancer was reassessed by means of a meta-analysis of data with center randomization from 1,094 patients enrolled in three clinical trials. In all three trials, patients were followed up for at least 5 years after surgery and enrollment of the last patient and outcomes for standard chemotherapy were compared with those for chemotherapy plus PSK. The endpoints were overall survival and disease-free survival; and intent-to-treat analysis was performed without patient exclusion. Data were analyzed using the weighted average of the individual log hazard ratios. The overall survival risk ratio for all eligible patients was 0.71 (95% confidence interval (CI) : 0.55–0.90; P=0.006), and the disease-free survival risk ratio was 0.72 (95% CI: 0.58–0.90; P=0.003). The results of this meta-analysis suggest that adjuvant immunochemotherapy with PSK can improve both survival and disease-free survival of patients with curatively resected colorectal cancer.

Keywords

Adjuvant immunochemotherapy Colorectal cancer Meta-analysis Polysaccharide K 

Notes

Acknowledgements

This work was supported in part by the EBM center of Kyoto University and by Epidemiological and Clinical Research Information Network (ECRIN), a nonprofit organization.

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Copyright information

© Springer-Verlag 2005

Authors and Affiliations

  • Junichi Sakamoto
    • 1
  • Satoshi Morita
    • 2
  • Koji Oba
    • 1
  • Takanori Matsui
    • 3
  • Michiya Kobayashi
    • 4
  • Hiroaki Nakazato
    • 5
  • Yasuo Ohashi
    • 6
  • Meta-Analysis Group of the Japanese Society for Cancer of the Colon Rectum
    • 6
  1. 1.Department of Epidemiological& Clinical Research Information ManagementKyoto University Graduate School of MedicineKyotoJapan
  2. 2.Department of Epidemiology and Health Care ResearchKyoto University Graduate School of MedicineKyotoJapan
  3. 3.Department of SurgeryAichi Prefectural HospitalOkazakiJapan
  4. 4.Department of SurgeryKochi UniversityKochiIndia
  5. 5.Department of SurgeryYokoyama Gastrointestinal HospitalNagoyaJapan
  6. 6.Department of BiostatisticsSchool of Health Science and Nursing, University of TokyoTokyoJapan

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