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The effect of aging on cellular immunity against cancer in SR/CR mice

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Abstract

SR/CR mice are capable of mounting a highly effective response of leukocytes to large doses of lethal transplantable mouse cancer cells. This response is conferred by a dominant, germline-transmissible mutation independent of sex chromosomes. The resistance can be extended to a broad array of mouse and human cancer cells without harming normal cells. The effector cells are primarily composed of the leukocytes from the innate immune system including macrophages, neutrophils, and natural killer cells. The mice are cancer-free and healthy without detectable abnormality or shortened life span. However, the immune response mechanism of these SR/CR mice is dramatically modulated by the aging process. In this article, we summarize the lessons learned from these mice and discuss possible implications of these findings in our understanding of the effects of aging on the immunity against cancer.

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Acknowledgements

We thank Drs Lloyd Old and Andrew Simpson of the Ludwig Institute for Cancer Research for reading the manuscript and helpful discussions. The projects discussed in this article are supported by grants from the Charlotte Geyer Foundation, National Cancer Institute and Cancer Research Institute.

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  1. Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA

    Zheng Cui & Mark C. Willingham

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  1. Zheng Cui
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  2. Mark C. Willingham
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Correspondence to Zheng Cui.

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Cui, Z., Willingham, M.C. The effect of aging on cellular immunity against cancer in SR/CR mice. Cancer Immunol Immunother 53, 473–478 (2004). https://doi.org/10.1007/s00262-003-0488-2

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  • DOI: https://doi.org/10.1007/s00262-003-0488-2

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