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Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer

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Abstract

Heat shock proteins (HSPs) are a large family of proteins with different molecular weights and different intracellular localizations. These proteins undertake crucial functions in maintaining cell homeostasis, and therefore they have been conserved during evolution. Hsp70 and Grp94/gp96, due to their peptide chaperone capacity and their ability to actively interact with professional antigen-presenting cells (APCs), are also endowed with crucial immunological functions. The immunological properties of these proteins and their implications for vaccine in human cancer will be discussed. Immunological and clinical data of phase I/II studies in melanoma and colorectal cancer patients will be reviewed.

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Acknowledgements

This work was supported in part by Sigma Tau (Rome) and Antigenics (New York). We thank Grazia Barp for editorial assistance.

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Authors and Affiliations

  1. Unit of Immunotherapy of Human Tumors, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via G. Venezian 1, 20133, Milan, Italy

    Chiara Castelli, Licia Rivoltini, Francesca Rini & Giorgio Parmiani

  2. Unit of General Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via G. Venezian 1, 20133, Milan, Italy

    Filiberto Belli

  3. European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy

    Alessandro Testori

  4. Unit of Cancer Bioimmunotherapy, Department of Medical Oncology, Centro di Riferimento Oncologico, Via Pedemontana Occidentale 12, 33081, Aviano, Italy

    Michele Maio

  5. Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, USA

    Pramod K. Srivastava

  6. Unit of Hepatobiliary and Gastro-Pancreatic Surgery, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via G. Venezian 1, 20133, Milan, Italy

    Vincenzo Mazzaferro & Jorgelina Coppa

Authors
  1. Chiara Castelli
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  2. Licia Rivoltini
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  7. Vincenzo Mazzaferro
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  8. Jorgelina Coppa
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  9. Pramod K. Srivastava
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  10. Giorgio Parmiani
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Corresponding author

Correspondence to Giorgio Parmiani.

Additional information

This work was presented at the first Cancer Immunology and Immunotherapy Summer School, 8–13 September 2003, Ionian Village, Bartholomeio, Peloponnese, Greece.

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Castelli, C., Rivoltini, L., Rini, F. et al. Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer. Cancer Immunol Immunother 53, 227–233 (2004). https://doi.org/10.1007/s00262-003-0481-9

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  • DOI: https://doi.org/10.1007/s00262-003-0481-9

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