Abstract.
The effect of linomide, an immunomodulatory drug, on natural killer (NK) cells and T cell-dependent immune responses following syngeneic or allogeneic bone marrow transplantation (BMT) was investigated in BALB/c mice inoculated with B-cell leukemia (BCL1). Linomide given in the drinking water had no impact on graft survival or graft versus leukemia (GVL) effects. Although linomide regulates anti-self reactivity in mice with experimental and spontaneous autoimmune disorders, the anti-tumor effects induced by allogeneic donor lymphocytes were not affected. This indicates that different mechanisms regulate anti-self and anti-leukemia effects. Alternatively, linomide might affect the homing of self-reactive lymphocytes to specific target organs in autoimmune disorders, although the homing process may not be relevant to the control of leukemia by alloreactive lymphocytes.
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Weiss, L., Abdul-Hai, A., Shufaro, Y. et al. Linomide administration following bone marrow transplantation in mice. Cancer Immunol Immunother 51, 596–602 (2002). https://doi.org/10.1007/s00262-002-0311-5
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DOI: https://doi.org/10.1007/s00262-002-0311-5