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Abdominal Imaging

, Volume 25, Issue 3, pp 243–245 | Cite as

Cisapride or metoclopramide to accelerate small bowel transit during barium follow-through examination?

  • C. Hare
  • S. Halligan
  • C. I. Bartram
  • K. Platt
  • G. Raleigh
Article

Abstract

Background: Metoclopramide is commonly used to accelerate small bowel transit during barium follow-through (BaFT) examinations, but its action is unpredictable. Cisapride, commonly used to treat gastroesophageal reflux disease, also accelerates small bowel transit and may be a viable alternative. The two were compared in a prospective, randomized, blind study.

Methods: Patients attending for BaFT were randomized to receive either 10 mg cisapride or 20 mg metoclopramide orally 1 h before the barium suspension. BaFT was performed by using a standard technique, and small bowel transit and study quality were compared. Patients also noted any side effects experienced.

Results: Of 45 patients recruited, 27 received cisapride and 18 metoclopramide. Median transit time for the cisapride group was 30 min (range = 10–130 min) versus 67.5 min (range = 30–290 min) for the metoclopramide group (p= 0.019). Study quality was comparable. However, nine patients (33%) receiving cisapride experienced nausea versus only one subject (6%) receiving metoclopramide (p= 0.034).

Conclusions: This study suggests that cisapride is a more effective prokinetic agent than metoclopramide, but this benefit is offset by a higher incidence of side effects.

Key words: Intestines, radiography—Gastrointestinal tract, radiography. 

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Copyright information

© Springer-Verlag New York Inc. 2000

Authors and Affiliations

  • C. Hare
    • 1
  • S. Halligan
    • 1
  • C. I. Bartram
    • 1
  • K. Platt
    • 1
  • G. Raleigh
    • 1
  1. 1.Intestinal Imaging Centre, Level 4V, St. Mark's Hospital, Northwick Park, Watford Road, Harrow, HA1 3UJ, UKGB

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