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Multiparametric magnetic resonance imaging of the liver and spleen in Gaucher disease

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To assess liver and spleen characteristics of a population with Gaucher disease (GD) using multiparametric MRI and MR elastography (MRE) for evaluation of diffuse liver and spleen disease, which includes liver fat fraction, liver and spleen volume and iron deposition, and liver and spleen stiffness correlated with DS3 Severity Scoring System for Gaucher disease (GD-DS3).


We prospectively evaluated 41 patients with type 1 Gaucher disease using a 3.0 T MRI and MRE between January 2019 and February 2020. Clinical, laboratory, and imaging data was collected. Mann–Whitney, Kruskal–Wallis, and Spearman’s correlation were applied to evaluate liver and spleen MRI and MRE, clinical and laboratory variables, and GD-DS3. ERT and SRT treatment groups were compared.


Hepatomegaly was seen in 15% and splenomegaly in 42% of the population. Moderate and strong and correlations were found between liver and spleen iron overload (rho = 0.537; p = 0.002); between liver and spleen volume (rho = 0.692, p < 0.001) and between liver and spleen stiffness (rho = 0.453, p = 0.006). Moderate correlations were found between liver stiffness and GD-DS3 (rho = 0.559; p < 0.001) and between splenic volume and GD-DS3 (rho = 0.524; p = 0.001).


The prevalence of hepatosplenomegaly, liver fibrosis, and liver iron overload in treated patients with GD is low, which may be related to the beneficial effect of treatment. Liver MRE and splenic volume correlate with severity score and may be biomarkers of disease severity.

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We thank Carolina Braz Parente for English revision.


This work was supported by D’Or Institute for Research and Education (IDOR) and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) (E_32/2014 – Apoio à realização de pesquisas clínicas e translacionais no RJ – FAPERJ/IDOR – 2014).

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Correspondence to Daniella Braz Parente.

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Parente, D.B., de Melo Malta, F.C.M., de Souza Cravo, R. et al. Multiparametric magnetic resonance imaging of the liver and spleen in Gaucher disease. Abdom Radiol (2024).

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