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Diagnostic value of serum CA125 combined with PET/CT in ovarian cancer and tuberculous peritonitis in female patients

  • Special Section: Ovarian Cancer
  • Published:
Abdominal Radiology Aims and scope

Abstract

Purpose

To evaluate the diagnostic value of serum CA125 combined with 18F-FDG PET/CT in ovarian cancer (OC) and tuberculous peritonitis (TBP) in female patients and to establish a diagnostic scoring system.

Method

A total of 86 female patients (64 OC and 22 TBP) were included in this study. Serum CA125, PET/CT maximal intensity projection (MIP), maximal standardized uptake value, ovarian mass, ascites volume, and other indicators were analyzed and a diagnostic scoring system was established according to the weights of statistically significant indicators.

Results

Univariate analysis showed that serum CA125 in OC and TBP patients were 2079.9 ± 1651.3 U/mL and 448.3 ± 349.5 U/mL (P < 0.001). In MIP images, abdominal lesions were focal distribution in 92.2% (59/64) of OC patients and diffuse distribution in 95.5% (21/22) of TBP patients (P < 0.001). Ovarian masses could be observed in 82.8% (53/64) OC patients and 31.8% (7/22) TBP patients (P <0.001). The other indicators were not statistically significant. Logistic regression analysis showed that serum CA125 and MIP were independent risk factors for diagnosis. A diagnostic scoring system could be established based on serum CA125, MIP and ovarian mass, and the diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value were 98.4% (63/64), 95.5% (21/22), 97.7% (84/86), 98.4% (63/64), and 95.5% (21/22), respectively.

Conclusion

Serum CA125 combined with PET/CT is of great value in the diagnosis of OC and TBP. A simple and efficient diagnostic scoring system can be established using serum CA125, MIP image feature, and ovarian mass.

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Funding

This study was funded by the National Natural Science Foundation of China (No. 81641073) and the Yichang Medical and Health Research Project (No. A20-2-005)

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Author notes

  1. Peng Wang and Yawen Feng have contributed equally to this work and should be considered co-first authors.

Authors and Affiliations

  1. Department of Nuclear Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, PR China

    Peng Wang, Yawen Feng, Hui Feng, Yuqi Chen & Wenli Dai

  2. Yichang Key Laboratory of Nuclear Medicine and Molecular Imaging, Yichang, Hubei, PR China

    Peng Wang, Yawen Feng, Hui Feng, Yuqi Chen & Wenli Dai

  3. Department of Ultrasound, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, PR China

    Hongyan Qi

  4. Zhijiang People’s Hospital, Yichang, Hubei, PR China

    Guoliang Zeng

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  1. Peng Wang
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Correspondence to Guoliang Zeng or Wenli Dai.

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Conflict of interest

According to the Declaration of Helsinki, the study has been approved by the Medical Ethics Committee of Yichang Central People’s Hospital (also known as the first Clinical Medical College of Three Gorges University) with approval number A20-2-005. And written informed consent for the publication of clinical data was obtained from the patient. The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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This study was approved by the Ethics Committee of the First Clinical Medical College of China Three Gorges University, No. Z.20210125.

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Wang, P., Feng, Y., Qi, H. et al. Diagnostic value of serum CA125 combined with PET/CT in ovarian cancer and tuberculous peritonitis in female patients. Abdom Radiol 48, 3449–3457 (2023). https://doi.org/10.1007/s00261-023-03997-9

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  • DOI: https://doi.org/10.1007/s00261-023-03997-9

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