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Comparison of the diagnostic performance of biparametric and multiparametric MRI in detecting muscle invasion of bladder cancer located at the ureteral orifice

  • Kidneys, Ureters, Bladder, Retroperitoneum
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

To assess the diagnostic performance of biparametric magnetic resonance imaging (bp-MRI) in predicting detrusor muscle invasion for bladder cancer (BC) located at the ureteral orifice by comparing it with the Vesical Imaging Reporting and Data System (VI-RADS) system based on multiparametric MRI (mp-MRI).

Methods

Patients with histopathologically proven BC located at the ureteral orifice from December 2019 to November 2022 were analyzed retrospectively. Two sets, bp-MRI (set 1) and mp-MRI (set 2), were formed from the images. Both sets were evaluated independent of histopathology by three radiologists with different levels of experience in abdominal radiology. Receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic performance of VI-RADS in the prediction of muscle invasion. The intraclass correlation coefficient (ICC) was used to evaluate inter-reader agreement.

Results

Of 68 patients with BCs located at the ureteral orifice, 50 (48 males, median age: 72 years) met the study criteria. Out of the 50 patients, 36 had non-muscle invasive BC (pTa–T1) and 14 had muscle invasive BC (MIBC) (pT2–T4). In the comparison of VI-RADS categories with histopathologic data for MIBC detection, the area under the curve of the ROC analysis for the bp- and mp-MRI protocol was 1.000–0.986 for reader 1, 0.893–0.901 for reader 2, and 0.808–0.865 for reader 3. There was no statistically significant difference in predicting detrusor muscle invasion with the bp- and mp-MRI-based on VI-RADS categories for all readers (p = 0.126, 0.203, and 0.322, respectively). The ICCs between all the readers showed excellent agreement and were similar for both protocols.

Conclusion

The bp-MRI consisting of DWI and T2-WI can be used as an alternative to the mp-MRI in predicting detrusor muscle invasion for BCs located at the ureteral orifice; however, less experienced readers should exercise caution.

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Availability of data and material

Data generated or analyzed during the study are available from the corresponding author by request.

Code availability

Not applicable.

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No funding was received for this study.

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Authors and Affiliations

  1. Department of Radiology, Faculty of Medicine, Giresun University, Giresun, Turkey

    Uluhan Eryuruk, Merve Nur Tasdemir & Serdar Aslan

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  1. Uluhan Eryuruk
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  2. Merve Nur Tasdemir
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Contributions

UE—Conceptualization; Data curation; Formal analysis; Investigation; Methodology; Project administration; Resources; Validation; Visualization; Roles/Writing—original draft; Writing—review and editing. MNT—Conceptualization; Investigation; Resources; Visualization. SA—Formal analysis; Investigation; Visualization; Writing—review and editing. Supervision.

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Correspondence to Uluhan Eryuruk.

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Due to its retrospective design, we waived the requirement for informed consent.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. This retrospective study was approved by Institutional Review Board.

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Eryuruk, U., Tasdemir, M.N. & Aslan, S. Comparison of the diagnostic performance of biparametric and multiparametric MRI in detecting muscle invasion of bladder cancer located at the ureteral orifice. Abdom Radiol 48, 3174–3182 (2023). https://doi.org/10.1007/s00261-023-03979-x

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