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Feasibility of high-resolution readout-segmented echo-planar imaging with simultaneous multislice imaging in assessing rectal cancer

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Abstract

Purpose

To investigate the feasibility of high-resolution readout-segmented echo-planar imaging (rs-EPI) with simultaneous multislice (SMS) imaging to predict well-differentiated rectal cancer.Kindly check and confirm whether the Author Name 'Hongyun Huang ' is correctly identified.confirm

Methods

A total of eighty-three patients with nonmucinous rectal adenocarcinoma received both prototype SMS high-spatial-resolution and conventional rs-EPI sequences. Image quality was subjectively assessed by two experienced radiologists using a 4-point Likert scale (1 = poor, 4 = excellent). The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) and apparent diffusion coefficient (ADC) of the lesion were measured by two experienced radiologists in the objective assessment. Paired t tests or Mann‒Whitney U tests were used to compare the two groups. The areas under the receiver operating characteristic (ROC) curves (AUCs) were used to determine the predictive value of the ADCs in discriminating well-differentiated rectal cancer in the two groups. A two-sided p value < 0.05 represented statistical significance.Please check and confirm if the authors and affiliation details have been correctly identified. Amend if necessary.confirm

Results

In the subjective assessment, high-resolution rs-EPI had better image quality than conventional rs-EPI (p < 0.001). High-resolution rs-EPI also had a significantly higher SNR and CNR (p < 0.001). The T stage of rectal cancer was inversely correlated with the ADCs measured on high-resolution rs-EPI (r = -0.622, p < 0.001) and rs-EPI (r = -0.567, p < 0.001). The AUC of high-resolution rs-EPI in predicting well-differentiated rectal cancer was 0.768.

Conclusion

High-resolution rs-EPI with SMS imaging provided significantly higher image quality, SNRs, and CNRs and more stable ADC measurements than conventional rs-EPI. Additionally, the pretreatment ADC on high-resolution rs-EPI could discriminate well-differentiated rectal cancer.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Author notes

  1. Hongyun Huang and Mi Zhou are co-first author.

Authors and Affiliations

  1. Department of Radiology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, No. 32, West Second Section of First Ring Road, Qingyang District, Chengdu, 610072, People’s Republic of China

    Hongyun Huang, Mi Zhou, Tong Gong & Yuting Wang

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Contributions

HH conceived of the present idea. TG designed the study. HH and MZ contributed to the data analysis and interpretation. HH and MZ were major contributors and contributed equally to writing the manuscript. YT W revised the manuscript.

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Correspondence to Yuting Wang.

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This study was approved by our institutional ethics committee.

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Huang, H., Zhou, M., Gong, T. et al. Feasibility of high-resolution readout-segmented echo-planar imaging with simultaneous multislice imaging in assessing rectal cancer. Abdom Radiol 48, 2258–2269 (2023). https://doi.org/10.1007/s00261-023-03937-7

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