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Quantitative evaluation of renal tissue changes in patients with liver cirrhosis by shear wave elastography

  • Kidneys, Ureters, Bladder, Retroperitoneum
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

Hepatocirrhotic nephropathy progresses rapidly and has a poor prognosis, and early detection of renal changes in patients with cirrhosis is particularly important for its prevention and treatment. The objective of this study was to evaluate the value of shear wave elastography (SWE) in the early diagnosis of hepatocirrhotic nephropathy.

Methods

206 hepatic cirrhosis patients with normal conventional renal function were enrolled and divided into Child–Pugh grade A (Group A), Child–Pugh grade B (Group B), and Child–Pugh grade C (Group C) according to the Child–Pugh grading method. Meanwhile, 60 healthy volunteers matched in age and sex were selected as the control group. The maximum Young’s modulus (Emax), average Young’s modulus (Emean), and minimum Young’s modulus (Emin) of the left renal parenchyma were measured by SWE in all subjects. The Emax, Emean, and Emin values of the left renal parenchyma were compared between the cirrhosis and control groups.

Results

The Emax, Emean, and Emin values of left renal parenchyma in cirrhosis group were higher than those in control group (p = 0.00, 0.00, 0.00). The Emax, Emean, and Emin values of left renal parenchyma in cirrhosis group B and group C were higher than those in control group (p = 0.00, 0.00, 0.00; p = 0.00, 0.00, 0.00), but these values in cirrhosis group A were not significantly different from control group(p = 0.48, 0.52, 0.92). Comparison of the Emax, Emean, and Emin values in left renal parenchyma of three cirrhosis groups, the values of Group B and Group C were higher than those of Group A (p = 0.00, 0.00, 0.00; p = 0.00, 0.00, 0.00), and there was no significant difference between Group B and Group C (p = 0.71, 0.18, 0.39).

Conclusion

SWE can detect renal tissue damage in patients with liver cirrhosis earlier than changes identified during routine laboratory examination by quantitatively measuring the elastic parameters of renal parenchyma and may become a new method for early diagnosis of hepatorenal syndrome.

Graphical Abstract

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Data availability

The datasets analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

BMI:

Body Mass Index

Emax:

The maximum value of Young’s modulus

Emin:

The minimum value of Young’s modulus

Emean:

The mean value of Young’s modulus

HRS:

Hepatorenal syndrome

SWE:

Shear wave elastography

US:

Ultrasonography

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Acknowledgements

We thank the highly qualified native English-speaking editors at AJE for editing the English text of a draft of this manuscript.

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Authors and Affiliations

  1. Department of Ultrasonography, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, The Third Hospital of Shanxi Medical University, 99 Longcheng Street, Taiyuan City, 030032, Shanxi Province, China

    Huizhan Li, Dianxia Men, Meihong Jia, Zhifen Wang, Wenli Xiao, Jiping Xue & Chunsong Kang

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  1. Huizhan Li
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  2. Dianxia Men
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  3. Meihong Jia
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  4. Zhifen Wang
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  7. Chunsong Kang
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Contributions

Guarantor of integrity of the entire study: CK. Study concepts and design: CK and HL. Literature research: DM. Clinical studies: WX and MJ. Data analysis: ZW and WX. Statistical analysis: MJ and DM. Manuscript preparation: HL. Manuscript editing: CK, HL, and JX.

Corresponding author

Correspondence to Chunsong Kang.

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The authors declare no conflict of interest.

Ethical approval

This study was approved by the Medical Ethical Committee of Shanxi Bethune Hospital. This research was performed in accordance with relevant guidelines and regulations, and written informed consent with signatures was obtained from all participants or their legal guardians.

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Li, H., Men, D., Jia, M. et al. Quantitative evaluation of renal tissue changes in patients with liver cirrhosis by shear wave elastography. Abdom Radiol 48, 2085–2090 (2023). https://doi.org/10.1007/s00261-023-03881-6

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  • DOI: https://doi.org/10.1007/s00261-023-03881-6

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