Abstract
The role and method of image-based staging of anal cancer has evolved with the rapid development of newer imaging modalities and the need to address the rising incidence of this rare cancer. In 2014, the European Society of Medical Oncology mandated pelvic magnetic resonance imaging (MRI) for anal cancer and subsequently other societies such as the National Comprehensive Cancer Network followed suit with similar recommendations. Nevertheless, great variability exists from center to center and even within individual centers. Notably, this is in stark contrast to the imaging of the anatomically nearby rectal cancer. As participating team members for this malignancy, we embarked on a comprehensive literature review of anal cancer imaging to understand the relative merits of these new technologies which developed after computed tomography (CT), e.g., MRI and positron emission tomography/computed tomography (PET/CT). The results of this literature review helped to inform our next stage: questionnaire development regarding the imaging of anal cancer. Next, we distributed the questionnaire to members of the Society of Abdominal Radiology (SAR) Rectal and Anal Disease-Focused Panel, a group of abdominal radiologists with special interest, experience, and expertise in rectal and anal cancer, to provide expert radiologist opinion on the appropriate anal cancer imaging strategy. In our expert opinion survey, experts advocated the use of MRI in general (65% overall and 91–100% for primary staging clinical scenarios) and acknowledged the superiority of PET/CT for nodal assessment (52–56% agreement for using PET/CT in primary staging clinical scenarios compared to 30% for using MRI). We therefore support the use of MRI and PET and suggest further exploration of PET/MRI as an optimal combined evaluation. Our questionnaire responses emphasized the heterogeneity in imaging practice as performed at numerous academic cancer centers across the United States and underscore the need for further reconciliation and establishment of best imaging practice guidelines for optimized patient care in anal cancer.
References
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-49. doi: https://doi.org/10.3322/caac.21660.
National Cancer Institute Surveillance E, and End Results Program (SEER): Cancer Stat Facts: Anal Cancer. https://seer.cancer.gov/statfacts/html/anus.html (2022). Accessed April 12, 2022.
Nigro ND, Vaitkevicius VK, Considine B, Jr. Combined therapy for cancer of the anal canal: a preliminary report. Dis Colon Rectum. 1974;17(3):354-6. doi: https://doi.org/10.1007/BF02586980.
Tarantino D, Bernstein MA. Endoanal ultrasound in the staging and management of squamous-cell carcinoma of the anal canal: potential implications of a new ultrasound staging system. Dis Colon Rectum. 2002;45(1):16-22. doi: https://doi.org/10.1007/s10350-004-6108-1.
Herzog U, Boss M, Spichtin HP. Endoanal ultrasonography in the follow-up of anal carcinoma. Surg Endosc. 1994;8(10):1186-9. doi: https://doi.org/10.1007/bf00591047.
Glynne-Jones R, Nilsson PJ, Aschele C, Goh V, Peiffert D, Cervantes A, et al. Anal cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up. Eur J Surg Oncol. 2014;40(10):1165-76. doi: https://doi.org/10.1016/j.ejso.2014.07.030.
Geh I, Gollins S, Renehan A, Scholefield J, Goh V, Prezzi D, et al. Association of Coloproctology of Great Britain & Ireland (ACPGBI): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017) - Anal Cancer. Colorectal Dis. 2017;19 Suppl 1:82-97. doi: https://doi.org/10.1111/codi.13709.
Moureau-Zabotto L, Vendrely V, Abramowitz L, Borg C, Francois E, Goere D, et al. Anal cancer: French Intergroup Clinical Practice Guidelines for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, SNFCP). Dig Liver Dis. 2017;49(8):831-40. doi: https://doi.org/10.1016/j.dld.2017.05.011.
Stewart DB, Gaertner WB, Glasgow SC, Herzig DO, Feingold D, Steele SR, et al. The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for Anal Squamous Cell Cancers (Revised 2018). Dis Colon Rectum. 2018;61(7):755-74. doi: https://doi.org/10.1097/DCR.0000000000001114.
Rao S, Guren MG, Khan K, Brown G, Renehan AG, Steigen SE, et al. Anal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(). Ann Oncol. 2021;32(9):1087-100. doi: https://doi.org/10.1016/j.annonc.2021.06.015.
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®): Anal Carcinoma V.1.2022. https://www.nccn.org/professionals/physician_gls/pdf/anal.pdf (2022). Accessed April 12, 2022.
Sekhar H, Zwahlen M, Trelle S, Malcomson L, Kochhar R, Saunders MP, et al. Nodal stage migration and prognosis in anal cancer: a systematic review, meta-regression, and simulation study. Lancet Oncol. 2017;18(10):1348-59. doi: https://doi.org/10.1016/S1470-2045(17)30456-4.
Beets-Tan RGH, Lambregts DMJ, Maas M, Bipat S, Barbaro B, Curvo-Semedo L, et al. Magnetic resonance imaging for clinical management of rectal cancer: Updated recommendations from the 2016 European Society of Gastrointestinal and Abdominal Radiology (ESGAR) consensus meeting. Eur Radiol. 2018;28(4):1465-75. doi: https://doi.org/10.1007/s00330-017-5026-2.
Oxford Centre for Evidence-Based Medicine: Oxford Centre for Evidence-Based Medicine: Levels of Evidence (March 2009). https://www.cebm.ox.ac.uk/resources/levels-of-evidence/oxford-centre-for-evidence-based-medicine-levels-of-evidence-march-2009 (2009). Accessed April 12, 2022.
Caldarella C, Annunziata S, Treglia G, Sadeghi R, Ayati N, Giovanella L. Diagnostic performance of positron emission tomography/computed tomography using fluorine-18 fluorodeoxyglucose in detecting locoregional nodal involvement in patients with anal canal cancer: a systematic review and meta-analysis. ScientificWorldJournal. 2014;2014:196068. doi: https://doi.org/10.1155/2014/196068.
Mahmud A, Poon R, Jonker D. PET imaging in anal canal cancer: a systematic review and meta-analysis. Br J Radiol. 2017;90(1080):20170370. doi: https://doi.org/10.1259/bjr.20170370.
Winton E, Heriot AG, Ng M, Hicks RJ, Hogg A, Milner A, et al. The impact of 18-fluorodeoxyglucose positron emission tomography on the staging, management and outcome of anal cancer. Br J Cancer. 2009;100(5):693-700. doi: https://doi.org/10.1038/sj.bjc.6604897.
Duimering A, Riauka T, Nijjar Y, Ghosh S, MacEwan R, Warkentin H, et al. Prognostic utility of pre- and post-treatment FDG-PET parameters in anal squamous cell carcinoma. Radiother Oncol. 2019;136:21-8. doi: https://doi.org/10.1016/j.radonc.2019.03.014.
Leccisotti L, Manfrida S, Barone R, Ripani D, Tagliaferri L, Masiello V, et al. The prognostic role of FDG PET/CT before combined radio-chemotherapy in anal cancer patients. Ann Nucl Med. 2020;34(1):65-73. doi: https://doi.org/10.1007/s12149-019-01416-y.
Rusten E, Rekstad BL, Undseth C, Klotz D, Hernes E, Guren MG, et al. Anal cancer chemoradiotherapy outcome prediction using (18)F-fluorodeoxyglucose positron emission tomography and clinicopathological factors. Br J Radiol. 2019;92(1097):20181006. doi: https://doi.org/10.1259/bjr.20181006.
Kidd EA, Dehdashti F, Siegel BA, Grigsby PW. Anal cancer maximum F-18 fluorodeoxyglucose uptake on positron emission tomography is correlated with prognosis. Radiother Oncol. 2010;95(3):288-91. doi: https://doi.org/10.1016/j.radonc.2010.02.019.
Deantonio L, Milia ME, Cena T, Sacchetti G, Perotti C, Brambilla M, et al. Anal cancer FDG-PET standard uptake value: correlation with tumor characteristics, treatment response and survival. Radiol Med. 2016;121(1):54-9. doi: https://doi.org/10.1007/s11547-015-0562-9.
Sadeghi R, Harsini S, Qodsi Rad MA, Dabbagh VR, Treglia G. Prognostic Significance of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography in Anal Squamous Cell Carcinoma: A Systematic Review and a Meta-Analysis. Contrast Media Mol Imaging. 2018;2018:9760492. doi: https://doi.org/10.1155/2018/9760492.
Manafi-Farid R, Kupferthaler A, Wundsam H, Gruber G, Vali R, Venhoda C, et al. Additional Value of 2-[(18)F]FDG PET/CT Comparing to MRI in Treatment Approach of Anal Cancer Patients. J Clin Med. 2020;9(9). doi: https://doi.org/10.3390/jcm9092715.
Rusten E, Rekstad BL, Undseth C, Al-Haidari G, Hanekamp B, Hernes E, et al. Target volume delineation of anal cancer based on magnetic resonance imaging or positron emission tomography. Radiat Oncol. 2017;12(1):147. doi: https://doi.org/10.1186/s13014-017-0883-z.
James RD, Glynne-Jones R, Meadows HM, Cunningham D, Myint AS, Saunders MP, et al. Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2 x 2 factorial trial. Lancet Oncol. 2013;14(6):516-24. doi: https://doi.org/10.1016/S1470-2045(13)70086-X.
Gollub MJ, Arya S, Beets-Tan RG, dePrisco G, Gonen M, Jhaveri K, et al. Use of magnetic resonance imaging in rectal cancer patients: Society of Abdominal Radiology (SAR) rectal cancer disease-focused panel (DFP) recommendations 2017. Abdom Radiol (NY). 2018;43(11):2893-902. doi: https://doi.org/10.1007/s00261-018-1642-9.
Goh V, Gollub FK, Liaw J, Wellsted D, Przybytniak I, Padhani AR, et al. Magnetic resonance imaging assessment of squamous cell carcinoma of the anal canal before and after chemoradiation: can MRI predict for eventual clinical outcome? Int J Radiat Oncol Biol Phys. 2010;78(3):715-21. doi: https://doi.org/10.1016/j.ijrobp.2009.08.055.
Koh DM, Dzik-Jurasz A, O'Neill B, Tait D, Husband JE, Brown G. Pelvic phased-array MR imaging of anal carcinoma before and after chemoradiation. Br J Radiol. 2008;81(962):91-8. doi: https://doi.org/10.1259/bjr/96187638.
Roach SC, Hulse PA, Moulding FJ, Wilson R, Carrington BM. Magnetic resonance imaging of anal cancer. Clin Radiol. 2005;60(10):1111-9. doi: https://doi.org/10.1016/j.crad.2005.05.008.
Johnson N, Pellino G, Simillis C, Qiu S, Nikolaou S, Baird DL, et al. Discrepancies between NCCN and ESMO guidelines in the management of anal cancer: a qualitative review. Updates Surg. 2017;69(3):345-9. doi: https://doi.org/10.1007/s13304-017-0470-8.
Gourtsoyianni S, Goh V. MRI of anal cancer: assessing response to definitive chemoradiotherapy. Abdom Imaging. 2014;39(1):2-17. doi: https://doi.org/10.1007/s00261-013-0032-6.
Owczarczyk K, Prezzi D, Cascino M, Kozarski R, Gaya A, Siddique M, et al. MRI heterogeneity analysis for prediction of recurrence and disease free survival in anal cancer. Radiother Oncol. 2019;134:119-26. doi: https://doi.org/10.1016/j.radonc.2019.01.022.
Muirhead R, Bulte D, Cooke R, Chu KY, Durrant L, Goh V, et al. A Prospective Study of Diffusion-weighted Magnetic Resonance Imaging as an Early Prognostic Biomarker in Chemoradiotherapy in Squamous Cell Carcinomas of the Anus. Clin Oncol (R Coll Radiol). 2020;32(12):874-83. doi: https://doi.org/10.1016/j.clon.2020.09.003.
Prezzi D, Mandegaran R, Gourtsoyianni S, Owczarczyk K, Gaya A, Glynne-Jones R, et al. The impact of MRI sequence on tumour staging and gross tumour volume delineation in squamous cell carcinoma of the anal canal. Eur Radiol. 2018;28(4):1512-9. doi: https://doi.org/10.1007/s00330-017-5133-0.
Acknowledgements
The authors would like to thank Kendra Godwin and Andrew Chua for their help in the literature review process; Doenja Lembregts MD, PhD, for her help in organizing and displaying the data results, and Joanne Chin for her help in preparation of the manuscript.
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This work was partially supported by the NIH/NCI Cancer Center Support Grant P30 CA008748.
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DDBB is a consultant for the Boston Imaging Core Lab. The remaining authors have no conflicts of interest to declare.
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Golia Pernicka, J.S., Rauch, G.M., Gangai, N. et al. Imaging of Anal Squamous Cell Carcinoma: Survey Results and Expert Opinion from the Rectal and Anal Cancer Disease-Focused Panel of the Society of Abdominal Radiology. Abdom Radiol 48, 3022–3032 (2023). https://doi.org/10.1007/s00261-023-03863-8
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DOI: https://doi.org/10.1007/s00261-023-03863-8