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A methodological study of 2D shear wave elastography for noninvasive quantitative assessment of renal fibrosis in patients with chronic kidney disease

  • Kidneys, Ureters, Bladder, Retroperitoneum
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

To determine the optimal measurement method of 2D shear wave elastography (2D-SWE) for noninvasive quantitative assessment of renal fibrosis in chronic kidney disease (CKD) patients.

Methods

A total of 190 CKD patients were enrolled for 2D-SWE of right kidney. The success rates, coefficients of variation (CV), and pathological correlation of different measurement sites, body positions, and depths were compared.

Results

(1) Measurement sites: Success rate in the middle part (100%) was higher than that in the lower pole (97.3%, P > 0.05). CV in the middle part (10.2%) was lower than that in the lower pole (16.4%, P < 0.05). Pathological correlation of the middle part (r =  − 0.452, P < 0.05) was higher than that of the lower pole (r = 0.097, P > 0.05). (2) Body positions: Success rate in left lateral decubitus position (100%) was higher than that in supine (99.4%, P > 0.05) and prone position (99.4%, P > 0.05). CV was lowest (11.9%) and pathological correlation was highest (r = -0.256, P < 0.05) in prone position. (3) Measurement depths: Success rate at depth < 4 cm (100%) was higher than that at depth ≥ 4 cm (98.8%, P > 0.05). CV at depth < 4 cm (11.1%) was lower than that at depth ≥ 4 cm (14.4%, P < 0.05). Pathological correlation at depth < 4 cm (r =  − 0.303, P < 0.05) was higher than that at depth ≥ 4 cm (r =  − 0.156, P > 0.05).

Conclusion

The optimal measurement method of 2D-SWE for renal fibrosis assessment was prone position, renal middle part, and measurement depth < 4 cm.

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Abbreviations

2D-SWE:

2D shear wave elastography

BMI:

Body Mass Index

CKD:

Chronic kidney disease

CV:

Coefficients of variation

eGFR:

Estimated glomerular filtration rate

SD:

Standard deviation

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Funding

The authors did not receive support from any organization for the submitted work.

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Author notes

  1. Yanjun Lin and Jiaxin Chen contributed equally to this article as first authors.

Authors and Affiliations

  1. Department of Ultrasound, Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, 519000, Guangdong Province, China

    Yanjun Lin, Jiaxin Chen, Yongquan Huang, Yuhong Lin & Zhongzhen Su

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Contributions

Conceptualization: ZS, YL, YH; Methodology: JC, YH, ZS; Formal analysis and investigation: YL, JC; Writing—original draft preparation: YL; Writing—review and editing: JC, YH, YL, ZS; Resources: ZS; Supervision: ZS, YL, YH.

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Correspondence to Yuhong Lin or Zhongzhen Su.

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The authors have no relevant financial or non-financial interests to disclose.

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This is an observational study. The ethics committee at the Fifth Affiliated Hospital of Sun Yat-sen University has confirmed that no ethical approval is required.

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Informed consent was obtained from all individual participants included in the study.

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Zhongzhen Su and Yuhong Lin are co-corresponding authors of this article.

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Lin, Y., Chen, J., Huang, Y. et al. A methodological study of 2D shear wave elastography for noninvasive quantitative assessment of renal fibrosis in patients with chronic kidney disease. Abdom Radiol 48, 987–998 (2023). https://doi.org/10.1007/s00261-022-03753-5

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  • DOI: https://doi.org/10.1007/s00261-022-03753-5

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